US5159095A
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Substituted silyl alcohols
Assignee: Abbott Laboratories
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Filing: 1991-06-07
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Granted: 1992-10-27
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Expires: 2011-06-07
Abstract
Abstract Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing substituted alcohols include hydrosilation of a vinylic ester, especially vinyl acetate, followed by hydrolysis in mild base. The silyl alcohols are useful in preparing phosphorylating reagents for phosphorylating an oligonucleotide. The phosphorylated intermediate bearing the silyl group may be separated from failure product on the basis of bulky substituents on the silyl protecting group, which is later removed, e.g. by fluoride ion.
Inventors
- 👤 Joseph E. Celebuski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:38
CPC Classifications
C; C07; C07H; C07H1/00; C07H1/02; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/0803; C07F7/081; C07F7/18; C07F9/00; C07F9/02; C07F9/06; C07F9/22; C07F9/24; C07F9/2404; C07F9/2408; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
44 words
An alcoholic compound of the formula: ##STR18## wherein R 1 , R 2 and R 3 are independently selected from the group consisting of aryl, substituted aryl, and substituted or unsubstituted sterically bulky alkyl; and n is an integer from 2 to about 20.
Claim 2
Dependent Claim
44 words
An alcoholic compound of the formula: ##STR18## wherein R 1 , R 2 and R 3 are independently selected from the group consisting of aryl, substituted aryl, and substituted or unsubstituted sterically bulky alkyl; and n is an integer from 2 to about 20.
Claim 3
Dependent Claim
20 words
The compound of claim 1 wherein R 1 , R 2 and R 3 are independently aryl, or substituted aryl.
Claim 4
Dependent Claim
17 words
The compound of claim 2 wherein R 1 , R 2 and R 3 are each phenyl.
Claim 5
Dependent Claim
33 words
The compound of claim 1 wherein R 1 , R 2 and R 3 are independently selected from the group consisting of bulky alkyl, substituted bulky alkyl, bulky aralkyl or substituted bulky aralkyl.
Claim 6
Dependent Claim
29 words
The compound of claim 4 wherein R 1 , R 2 and R 3 are independently selected from the group consisting of t-butyl, neopentyl, neohexyl, cyclohexyl, 3-pentyl and 3-ethyl-3-pentyl.
Claim 7
Dependent Claim
34 words
The compound of claim 1 wherein R 1 , R 2 and R 3 are independently selected from the group consisting of phenyl, substituted phenyl, naphthyl, triphenylmethyl, t-butyl, neopentyl, neohexyl, cyclohexyl, 3-pentyl and 3-ethyl-3-pentyl.
Claim 8
Dependent Claim
13 words
The compound of claim 1 wherein n is from 2 to about 6.
Claim 9
Dependent Claim
9 words
The compound of claim 7 wherein n is 2.
Claim 10
Dependent Claim
49 words
An ester compound of the formula: ##STR19## wherein R 1 , R 2 and R 3 are independently selected from the group consisting of aryl, substituted aryl, and substituted or unsubstituted sterically bulky alkyl; R 4 is lower alkyl; and n is an integer from 2 to about 20.
Claim 11
Dependent Claim
49 words
An ester compound of the formula: ##STR19## wherein R 1 , R 2 and R 3 are independently selected from the group consisting of aryl, substituted aryl, and substituted or unsubstituted sterically bulky alkyl; R 4 is lower alkyl; and n is an integer from 2 to about 20.
Claim 12
Dependent Claim
20 words
The compound of claim 9 wherein R 1 , R 2 and R 3 are independently aryl, or substituted aryl.
Claim 13
Dependent Claim
17 words
The compound of claim 10 wherein R 1 , R 2 and R 3 are each phenyl.
Claim 14
Dependent Claim
33 words
The compound of claim 9 wherein R 1 , R 2 and R 3 are independently selected from the group consisting of bulky alkyl, substituted bulky alkyl, bulky aralkyl or substituted bulky aralkyl.
Claim 15
Dependent Claim
29 words
The compound of claim 12 wherein R 1 , R 2 and R 3 are independently selected from the group consisting of t-butyl, neopentyl, neohexyl, cyclohexyl, 3-pentyl and 3-ethyl-3-pentyl.
Claim 16
Dependent Claim
34 words
The compound of claim 9 wherein R 1 , R 2 and R 3 are independently selected from the group consisting of phenyl, substituted phenyl, naphthyl, triphenylmethyl, t-butyl, neopentyl, neohexyl, cyclohexyl, 3-pentyl and 3-ethyl-3-pentyl.
Claim 17
Dependent Claim
13 words
The compound of claim 9 wherein n is from 2 to about 6.
Claim 18
Dependent Claim
9 words
The compound of claim 15 wherein n is 2.
Claim 19
Dependent Claim
10 words
The compound of claim 9 wherein R 4 is methyl.
References Cited (Backward Citations)
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