2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof

Claim 1

An imidazo[1,2-c]quinazoline compound having the formula ##STR29## which comprises racemic mixture of optically active compounds or optically pure R and S stereoisomers, wherein: X is O or S; R 1 is hydrogen, lower alkyl, phenyl or phenyl (lower alkyl); R 2 is hydrogen, lower alkyl, phenyl or phenyl (lower alkyl); or R 1 and R 2 together represent alkylene of 4 to 10 carbon atoms or ##STR30## wherein R 5 represents (a) 2-(2-hydroxyethoxy)ethyl; (b) pyrimidinyl; (c) a 2-, 3- or 4-pyridinyl optionally substituted by one or two substituents each independently selected from the group consisting of C 1 -C 4 alkyl; and (d) benzoyl, benzyl, phenyl and diphenylmethyl optionally substituted by one or two substituents selected from the group consisting of halogen atom, methoxy, trifluoromethyl, C 1 -C 4 alkyl, nitro, acetyl, and cyano; and (i) R 6 and R 7 together represent alkylene of 4 to 6 carbon atoms or (ii) ##STR31## or (iii) when R 6 represents hydrogen atom or hydroxy, R 7 represents (a) pyrimidinyl; (b) a 2-, 3- or 4-pyridinyl optionally substituted by one or two substituents each independently selected from the group consisting of C 1 -C 4 alkyl; and (c) benzoyl, benzyl, phenyl and diphenylmethyl optionally substituted by one or two substituents selected from the group consisting of halogen atom, methoxy, trifluoromethyl, C 1 -C 4 alkyl, nitro, acetyl, and cyano; R 3 is halogen, hydrogen, lower alkyl, trifluoromethyl, or lower alkoxy; and R 4 is halogen, hydrogen, lower alkyl, trifluoromethyl, or lower alkoxy; or pharmaceutically acceptable salts thereof.