US5157455A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus for the calibration and quality control of a spectrophotometer
Assignee: Individual
•
Filing: 1990-08-07
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Granted: 1992-10-20
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Expires: 2010-08-07
Abstract
Abstract An apparatus for the calibration and quality assurance of a multichannel spectrophotometer, particularly an ELISA spectrophotometer, comprises film selectively exposed in the presence of a color to produce a series of filters having a known first color and linearly increasing optical density. The response of the spectrophotometer is measured against the known color and linearly increasing optical density. Additional filters of at least one additional color permit checking the color response of the spectrophotometer. An algorithm determines whether the response conforms to predetermined conditions. An output is produced to provide a record of the calibration and quality assurance of the spectrophotometer. The invention has particular utility for conducting calibration and quality assurance of ELISA spectrophotometers used in clinical laboratory screening for infectious diseases, such as Hepatitis B. and the AIDS viruses.
Inventors
- 👤 James N. Macri
- 👤 Edward J. Cook
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 11:48
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/27; G01N21/274; G01N2201/00; G01N2201/04; G01N2201/0446; G01N2201/12; G01N2201/13
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
94 words
A quality monitoring apparatus for a photometer used to sample a plurality of samples, the photometer having at least one light source and at least one detector for generating signals corresponding to light from the samples, the quality monitoring apparatus comprising: a sheet of photographic film having at least one filter having an optical density of a known value and a first color and corresponding to an area of the film that has been selectively exposed, each filter being positioned at a location at which the photometer samples one of the plurality of samples.
Claim 2
Dependent Claim
94 words
A quality monitoring apparatus for a photometer used to sample a plurality of samples, the photometer having at least one light source and at least one detector for generating signals corresponding to light from the samples, the quality monitoring apparatus comprising: a sheet of photographic film having at least one filter having an optical density of a known value and a first color and corresponding to an area of the film that has been selectively exposed, each filter being positioned at a location at which the photometer samples one of the plurality of samples.
Claim 3
Dependent Claim
64 words
The quality monitoring apparatus of claim 1 wherein the sheet of film further comprises: a plurality of said filters each filter having an optical density of a known value which si the same or different than other filters and a first color, and wherein the filters are positioned at more than one location at which the photometer samples one of the plurality of samples.
Claim 4
Dependent Claim
19 words
A quality monitoring apparatus as claimed in claim 2, wherein the film further comprises filters having a second color.
Claim 5
Dependent Claim
46 words
A quality monitoring apparatus as claimed in claim 2, wherein the filters are arranged in an eight row by twelve column matrix comprising two columns each of: zero optical density filters, second color filters and each of four different optical densities of the first color filters.
Claim 6
Dependent Claim
25 words
A quality monitoring apparatus as claimed in claim 4, wherein the four different optical densities of the filters of the first color increase linearly sequentially.
Claim 7
Dependent Claim
31 words
A quality monitoring apparatus as claimed in claim 5, wherein the linear increase in the optical density of the filters is obtained by increasing the time of exposure of the film.
Claim 8
Dependent Claim
29 words
The quality monitoring apparatus of claim 2 wherein the outside dimensions of the sheet of film substantially correspond to outside dimensions of a standard ELISA spectrophotometer sample well plate.
Claim 9
Dependent Claim
43 words
The quality monitoring apparatus of claim 4 wherein each filter in the matrix of filters corresponds in location to the 8 by 12 matrix of positions at which the photometer samples one of sample wells in a standard ELISA spectrophotometer sample well plate.
Claim 10
Dependent Claim
44 words
The quality monitoring apparatus of claim 5 wherein each filter in the matrix of filters corresponds in location to the 8 by 12 matrix of positions at which the photometer samples one of the sample wells in a standard ELISA spectrophotometer sample well plate.
Claim 11
Dependent Claim
29 words
The quality monitoring apparatus of claim 9 wherein the outside dimensions of the sheet of film substantially correspond to outside dimension of a standard ELISA spectrophotometer sample well plate.
Claim 12
Dependent Claim
42 words
The quality monitoring apparatus of claim 10 further comprising two sheets of clear plastic, each having outside dimensions that substantially correspond to outside dimensions of a standard ELISA spectrophotometer sample well plate and wherein the film is disposed between said two sheets.
Claim 13
Dependent Claim
68 words
A quality monitoring apparatus as claimed in claim 2 wherein the filters are arranged in an eight row by twelve column matrix comprising two columns of zero optical density filters, two columns of the first color filters at a first optical density, two columns each of the first color filters at three different optical densities, different from the first optical density, and two columns of second color filters.
Claim 14
Dependent Claim
25 words
The quality monitoring apparatus as claimed in claim 12 wherein the four different optical densities of the filters of the first color increase linearly sequentially.
Claim 15
Dependent Claim
44 words
The quality monitoring apparatus of claim 12 wherein each filter in the matrix of filters corresponds in location to the 8 by 12 matrix of position at which the photometer samples one of the sample wells in a standard ELISA spectrophotometer sample well plate.
Claim 16
Dependent Claim
44 words
The quality monitoring apparatus of claim 13 wherein each filter in the matrix of filters corresponds in location to the 8 by 12 matrix of positions at which the photometer samples one of the sample wells in a standard ELISA spectrophotometer sample well plate.
Claim 17
Dependent Claim
30 words
The quality monitoring apparatus of claim 14 wherein the outside dimensions of the sheet of film substantially correspond to the outside dimensions of a standard ELISA spectrophotometer sample well plate.
Claim 18
Dependent Claim
42 words
The quality monitoring apparatus of claim 16 further comprising two sheet of clear plastic, each having outside dimensions that substantially correspond to outside dimensions of a standard ELISA spectrophotometer sample well plate and wherein the film is disposed between said two sheets.
Claim 19
Dependent Claim
30 words
The quality monitoring apparatus of claim 15 wherein the outside dimensions of the sheet of film substantially correspond to the outside dimensions of a standard ELISA spectrophotometer sample well plate.
Claim 20
Dependent Claim
42 words
The quality monitoring apparatus of claim 18 further comprising two sheet of clear plastic, each having outside dimensions that substantially correspond to outside dimensions of a standard ELISA spectrophotometer sample well plate and wherein the film is disposed between said two sheets.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-20 | 1996-04-20 | 1996-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-20 | 2000-04-20 | 2000-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-20 | 2004-04-20 | 2004-10-20 | $7700.00 | Window Closed / Lapsed |