US5155257A
Expired / Lapsed
US
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Process for the preparation of acylaminomethanephosphonic acids
Assignee: Hoechst AG
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Filing: 1991-10-08
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Granted: 1992-10-13
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Expires: 2011-10-08
Abstract
Abstract Acylaminomethanephosphonic acids are useful intermediates for the preparation of the herbicide N-phosphonemethylglycine and its salts. According to the invention, acylaminomethanephosphonic acids of the formula (I) R.sup.1 --CO--NHCH.sub.2 P(═O) (OH).sub.2 (I) in which R 1 is H, C 1 -C 6 -alkyl, benzyl or optionally substituted phenyl, can be prepared in a process which can be employed industrially, which comprises the reaction of the compound of the formula R 1 --CO-NH--CH 2 OH with P 2 O 3 and then hydrolysis with water.
Inventors
- 👤 Hans-Jerg Kleiner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:48
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
87 words
A process for the preparation of a compound of the formula I ##STR2## in which R 1 is H, C 1 -C 6 -alkyl, benzyl or phenyl, which is unsubstituted or substituted by one or more radicals from the group comprising C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halogen, which comprises reacting a compound of the formula II R.sup.1 --CO--NH--CH.sub.2 --OH (II) in which R 1 has the abovementioned meaning, with diphosphorus trioxide (P 2 O 3 ) and then hydrolyzing with water.
Claim 2
Dependent Claim
87 words
A process for the preparation of a compound of the formula I ##STR2## in which R 1 is H, C 1 -C 6 -alkyl, benzyl or phenyl, which is unsubstituted or substituted by one or more radicals from the group comprising C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halogen, which comprises reacting a compound of the formula II R.sup.1 --CO--NH--CH.sub.2 --OH (II) in which R 1 has the abovementioned meaning, with diphosphorus trioxide (P 2 O 3 ) and then hydrolyzing with water.
Claim 3
Dependent Claim
20 words
The process as claimed in claim 1, wherein R 1 is H, C 1 -C 3 -alkyl, benzyl or phenyl.
Claim 4
Dependent Claim
16 words
The process as claimed in claim 1, wherein R 1 is hydrogen, methyl, ethyl or phenyl.
Claim 5
Dependent Claim
12 words
The process as claimed in claim 1, wherein R 1 is methyl.
Claim 6
Dependent Claim
12 words
The process as claimed in claim 1, wherein R 1 is phenyl.
Claim 7
Dependent Claim
33 words
The process as claimed in claim 1, wherein the compound of the formula II and P 2 O 3 are reacted in a molar ratio II:P 2 O 3 of at most 2:1.
Claim 8
Dependent Claim
16 words
The process as claimed in claim 6, wherein the molar ratio is from 2:1 to 1.5:1.
Claim 9
Dependent Claim
24 words
The process as claimed in claim 1, wherein the reaction temperature for the reaction with P 2 O 3 is 60° to 200° C.
Claim 10
Dependent Claim
40 words
The process as claimed in claim 1, wherein the hydrolysis is carried out with water in a molar ratio of water to P 2 O 3 employed of at least 1:1 and at a temperature of 10° to 200° C.
Claim 11
Dependent Claim
32 words
The process as claimed in claim 1, wherein the reaction of the compound of the formula II and P 2 O 3 is carried out in the presence of an organic solvent.
Claim 12
Dependent Claim
19 words
The process as claimed in claim 10, wherein the solvent is an inert polar protic or aprotic organic solvent.
Claim 13
Dependent Claim
20 words
The process as claimed in claim 6, wherein R 1 is H, C 1 -C 3 -alkyl, benzyl or phenyl.
Claim 14
Dependent Claim
16 words
The process as claimed in claim 12, wherein the molar ratio is from 2:1 to 1.5:1.
Claim 15
Dependent Claim
25 words
The process as claimed in claim 12, wherein the reaction temperature for the reaction with P 2 O 3 is 60° to 200 ° C.
Claim 16
Dependent Claim
25 words
The process as claimed in claim 13, wherein the reaction temperature for the reaction with P 2 O 3 is 60° to 200 ° C.
Claim 17
Dependent Claim
41 words
The process as claimed in claim 12, wherein the hydrolysis is carried out with water in a molar ratio of water to P 2 O 3 employed of at least 1:1 and at a temperature of 10° to 200 ° C.
Claim 18
Dependent Claim
25 words
The process as claimed in claim 16, wherein the reaction temperature for the reaction with P 2 O 3 is 60° to 200 ° C.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-10-13 | 1996-04-13 | 1996-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-13 | 2000-04-13 | 2000-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-13 | 2004-04-13 | 2004-10-13 | $7700.00 | Window Closed / Lapsed |