US5151360A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
Assignee: Otsuka America Pharmaceutical Inc
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Filing: 1991-07-02
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Granted: 1992-09-29
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Expires: 2011-07-02
Abstract
Abstract The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory an anti-metastatic activity over related compounds.
Inventors
- 👤 Kazuko Handa
- 👤 Yasuyuki Igarashi
- 👤 Mahammad N. Ahmad
- 👤 Sen-itiroh Hakomori
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:08
CPC Classifications
C; C07; C07C; C07C215/00; C07C215/02; C07C215/40; A; A61; A61P; A61P29/00; A61P35/00; A61P37/00; A61P43/00; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
A method of modulating intercellular contact comprising exposing cells to a biologically effective amount of N,N-dimethylsphingosine or N,N,N-trimethylsphingosine wherein said biologically effective amount is an amount that inhibits the expression or function of a cell adhesion molecule.
Claim 2
Independent Claim
37 words
A method of modulating intercellular contact comprising exposing cells to a biologically effective amount of N,N-dimethylsphingosine or N,N,N-trimethylsphingosine wherein said biologically effective amount is an amount that inhibits the expression or function of a cell adhesion molecule.
Claim 3
Dependent Claim
24 words
The method of claim 1, wherein said cells are selected from the group consisting of immune system cells, endothelial cells, tumor cells and platelets.
Claim 4
Dependent Claim
12 words
The method of claim 1, wherein said adhesion molecule is a selectin.
Claim 5
Dependent Claim
12 words
The method of claim 3, wherein said selecting is ELAM or GMP-140.
Claim 6
Dependent Claim
8 words
The method of claim 1 which comprises N,N-dimethylsphingosine.
Claim 7
Dependent Claim
8 words
The method of claim 1 which comprises N,N,N-trimethylsphingosine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-29 | 1996-03-30 | 1996-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-29 | 2000-03-30 | 2000-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-29 | 2004-03-30 | 2004-09-29 | $7700.00 | Window Closed / Lapsed |