Preparation of 3,5-diamino benzotrifluoride

Claim 2

A process for the preparation of 3,5-diaminobenzotrifluoride which comprises treating 4-chloro-3,5-dinitrobenzotrifluoride, in a solvent selected from the group consisting of C-3 to C-6 secondary and tertiary alcohols, acetonitrile, low molecular weight esters of C-2 of C-4 alcohols and C-2 to C-4 acids, diethyl ether, tetrahydrofuran, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, and tetraethylene glycol dimethyl ether, with hydrogen gas under a pressure of about 50 to 300 psi, in the presence of a suitable catalyst which comprises palladium on an inert carrier, and in the presence of a base selected from the group consisting of alkali metal and alkaline earth metal carbonates and bicarbonates, and alkali metal salts of C-2 to C-6 aliphatic carboxylic acids.

Claim 3

A process according to claim 1 in which the solvent is selected from the group consisting of C-3 to C-6 secondary and tertiary alcohols.

Claim 4

A process according to claim 2 in which the catalyst is palladium on carbon.

Claim 5

A process according to claim 3 in which the solvent is isopropyl alcohol.

Claim 6

A process according to claim 4 in which the base is sodium carbonate.

Claim 7

A process according to claim 4 in which the base is sodium acetate.

Claim 8

A process according to claim 1 in which the solvent is an ether.

Claim 9

A process according to claim 7 in which the base is sodium carbonate.

Claim 10

A process according to claim 7 in which the base is sodium acetate.

Claim 11

A process according to claim 1 in which the solvent is a low molecular weight ester.

Claim 12

A process according to claim 10 in which the base is sodium carbonate.

Claim 13

A process according to claim 10 in which the base is sodium acetate.

Claim 14

A process according to claim 1 in which the solvent is ethyl acetate.

Claim 15

A process according to claim 13 in which the catalyst is palladium on carbon.

Claim 16

A process according to claim 14 in which the base is sodium carbonate.

Claim 17

A process according to claim 14 in which the base is sodium acetate.

Claim 18

A process for the preparation of 3,5-diaminobenzotrifluoride which comprises (1) preparing a mixture consisting essentially of (a) 4-chloro-3,5-dinitrobenzotrifluoride; (b) a solvent selected from the group consisting of C-3 to C-6 secondary and tertiary alcohols, acetonitrile, low molecular weight esters of C-2 to C-4 alcohols and C-2 to C-4 acids, diethyl ether, tetrahydrofuran, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, and tetraethylene glycol dimethyl ether; (c) hydrogen gas under a pressure of about 50 to about 300 psi; (d) a palladium catalyst; and (e) a base selected from the group consisting of alkali metal and alkaline earth metal carbonates and bicarbonates, and alkali metal salts of C-2 to C-6 aliphatic carboxylic acids; and (2) maintaining the temperature of said mixture to a temperature between room temperature and about 100° C.

Claim 19

A process for the preparation of 3,5-diaminobenzotrifluoride which comprises (1) preparing a mixture consisting essentially of (a) 4-chloro-3,5-dinitrobenzotrifluoride; (b) a solvent selected from the group consisting of C-3 to C-6 secondary and tertiary alcohols, acetonitrile, low molecular weight esters of C-2 to C-4 alcohols and C-2 to C-4 acids, diethyl ether, tetrahydrofuran, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, and tetraethylene glycol dimethyl ether; (c) hydrogen gas under a pressure of about 50 to about 300 psi; (d) a palladium catalyst; and (e) a base selected from the group consisting of alkali metal and alkaline earth metal carbonates and bicarbonates, and alkali metal salts of C-2 to C-6 aliphatic carboxylic acids; and (2) maintaining the temperature of said mixture to a temperature between room temperature and about 100° C.

Claim 20

A process according to claim 17 wherein said solvent is ethyl acetate.

Claim 21

A process according to claim 17 wherein said base is sodium carbonate.

Claim 22

A process according to claim 17 wherein said base is sodium acetate.