US5143071A — Non-stringy adhesive hydrophilic gels

Claim 1

Independent Claim 101 words

A non-stringy adhesive hydrophilic gel comprising a homogeneous mixture of water and at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture, said water-soluble polymer having a weight average molecular weight of at least about 200 kD, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp, substantially featureless force-displacement profile, has an Adhesion Energy Density (AED) of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

Claim 2

Dependent Claim 101 words

A non-stringy adhesive hydrophilic gel comprising a homogeneous mixture of water and at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture, said water-soluble polymer having a weight average molecular weight of at least about 200 kD, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp, substantially featureless force-displacement profile, has an Adhesion Energy Density (AED) of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

Claim 3

Dependent Claim 14 words

The gel of claim 1 in which said water-soluble polymer is poly(ethylene oxide) (PEO).

Claim 4

Dependent Claim 30 words

The gel of claim 1 in which said water-soluble polymer comprises poly(vinyl pyrrolidone) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD.

Claim 5

Dependent Claim 42 words

The gel of claim 1, 2 or 3 in which said mixture further comprises an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said gel to an impedance at 60 Hz of less than about 1,000 ohms.

Claim 6

Dependent Claim 34 words

The gel of claim 1, 2 or 3 in which said water-soluble polymer is present at a concentration of at least about 7 to less than about 35 percent by weight of said mixture.

Claim 7

Dependent Claim 32 words

The gel of claim 1, 2 or 3 in which said water-soluble polymer is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

Claim 8

Dependent Claim 19 words

The gel of claim 1, 2 or 3 in which said mixture further comprises an additive uniformly dispersed therein.

Claim 9

Dependent Claim 34 words

The gel of claim 7 in which said additive is selected from the group consisting of preservatives, stabilizers, fire retardants, pigments, refractive particles, bacteriacides, fungicides, antibiotics, cosmetics, moisturizers, pharmaceuticals, therapeutic agents, and mixtures thereof.

Claim 10

Dependent Claim 12 words

The gel of claim 7 in which said additive comprises a biocide.

Claim 11

Dependent Claim 27 words

The gel of claim 7 in which said additive is present at a concentration of about 0.001 percent to about 6 percent by weight of said mixture.

Claim 12

Dependent Claim 16 words

The gel of claim 1 which further comprises a low area-weight scrim in intimate contact therewith.

Claim 13

Dependent Claim 16 words

The gel of claim 11 in which said scrim is manufactured from a synthetic water-insoluble polymer.

Claim 14

Dependent Claim 13 words

The gel of claim 4 in which said electrolyte is an inorganic salt.

Claim 15

Dependent Claim 26 words

The gel of claim 4 in which said electrolyte is selected from the group consisting of alkali metal salts, alkaline earth metal salts, and mixtures thereof.

Claim 16

Dependent Claim 27 words

The gel of claim 4 in which said electrolyte is selected from the group consisting of potassium chloride, sodium chloride, magnesium sufate, magnesium acetate, and mixtures thereof.

Claim 17

Dependent Claim 27 words

The gel of claim 4 in which said electrolyte is present at a concentration of about 0.1 weight percent to about 10 weight percent of said mixture.

Claim 18

Dependent Claim 31 words

The gel of claim 1 in which said mixture had been exposed to a dose of radiant energy equivalent to greater than about 0.5 Mrad to less than about 4.5 Mrad.

Claim 19

Dependent Claim 27 words

The gel of claim 1 in which said mixture had been exposed to a dose of radiant energy equivalent to about 0.75 Mrad to about 2.5 Mrad.

Claim 20

Dependent Claim 44 words

The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer is selected from the group consisting of polyacrylamide, poly(vinyl alcohol), polacrylate, poly(ethylene oxide), poly(ethylene imine), carboxymethylcellulose, methylcellulose, polyacrylamide sulfonic acid, polyacrylonitrile, agar, dextran, dextrin, carageenan, xanthan, guar, derivatives, mixtures, blends, and copolymers thereof.

Claim 21

Dependent Claim 14 words

The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer comprises poly(ethylene oxide).

Claim 22

Dependent Claim 15 words

The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer comprises a cellulose derivative.

Claim 23

Dependent Claim 28 words

The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer is present at a concentration of about 0.5 to about 5 percent by weight of said mixture.

Claim 24

Dependent Claim 21 words

The gel of claim 1, 2 or 3 in which said mixture has a viscosity of at least about 8,000 cps.

Claim 25

Dependent Claim 49 words

The gel of claim 1, 2 or 3 in which said mixture further comprises an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said mixture to an impedance at frequencies between about 10 Hz to about 5 MHz of less than about 100 ohms.

Claim 26

Dependent Claim 22 words

The gel of claim 1 in which said water-soluble polymer has a weight average molecular weight of at least about 5,000 kD.

Claim 27

Dependent Claim 166 words

A non-stringy adhesive hydrophilic gel comprising a homogeneous mixture of water and poly(ethylene oxide) (PEO) present at a concentration of at least about 7 percent by weight to less than about 35 percent by weight of said mixture, said PEO having a weight average molecular weight of about 500 kD to about 5,000 kD, which mixture had been exposed to a dose of radiant energy, relative to the amount of said PEO present, within the area of the radiation dose versus PEO concentration curve whose upper and lower boundaries are defined substantially by the relationships NS(C) and A(C), respectively, Upper Dose, NS(C)=2.039+0.1598C-8.183/C Lower Dose, A(C)=1.245+0.0373C-3.908/C in which C is the concentration of said PEO expressed as a weight fraction of said mixture, which dose is effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

Claim 28

Dependent Claim 166 words

A non-stringy adhesive hydrophilic gel comprising a homogeneous mixture of water and poly(ethylene oxide) (PEO) present at a concentration of at least about 7 percent by weight to less than about 35 percent by weight of said mixture, said PEO having a weight average molecular weight of about 500 kD to about 5,000 kD, which mixture had been exposed to a dose of radiant energy, relative to the amount of said PEO present, within the area of the radiation dose versus PEO concentration curve whose upper and lower boundaries are defined substantially by the relationships NS(C) and A(C), respectively, Upper Dose, NS(C)=2.039+0.1598C-8.183/C Lower Dose, A(C)=1.245+0.0373C-3.908/C in which C is the concentration of said PEO expressed as a weight fraction of said mixture, which dose is effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

Claim 29

Dependent Claim 181 words

A non-stringy adhesive hydrophilic gel comprising a homogenous mixture of water, poly(vinyl pyrrolidone) (PVP) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD, said PVP having a weight average molecular weight of about 500 kD to about 2,000 kD and present at a concentration of at least about 6 percent to less than about 35 percent by weight of said mixture, which mixture had been exposed to a dose of radiant energy, relative to the amount of said PVP present, within the area of the radiation dose versus PVP concentration curve whose upper and lower boundaries are defined substantially by the relationships NS(C) and A(C), respectively, Upper Dose, NS(C)=1.122+0.099C-2.705/C Lower Dose, A(C)=0.471+0.0256C-1.394/C in which C is the concentration of said PVP expressed as a weight fraction of said mixture, which dose is effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

Claim 30

Dependent Claim 181 words

A non-stringy adhesive hydrophilic gel comprising a homogenous mixture of water, poly(vinyl pyrrolidone) (PVP) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD, said PVP having a weight average molecular weight of about 500 kD to about 2,000 kD and present at a concentration of at least about 6 percent to less than about 35 percent by weight of said mixture, which mixture had been exposed to a dose of radiant energy, relative to the amount of said PVP present, within the area of the radiation dose versus PVP concentration curve whose upper and lower boundaries are defined substantially by the relationships NS(C) and A(C), respectively, Upper Dose, NS(C)=1.122+0.099C-2.705/C Lower Dose, A(C)=0.471+0.0256C-1.394/C in which C is the concentration of said PVP expressed as a weight fraction of said mixture, which dose is effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

Claim 31

Dependent Claim 24 words

The gel of claim 1, 26 or 27 in which said AED value is at least about 7 to less than about 40 g/cm.

Claim 32

Dependent Claim 18 words

The gel of claim 28 in which said peak-force has a value of at least about 250 grams.

Claim 33

Dependent Claim 18 words

The gel of claim 28 in which said peak-force has a value of at least about 400 grams.

Claim 34

Dependent Claim 29 words

The gel of claim 26 in which said poly(ethylene oxide) is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

Claim 35

Dependent Claim 30 words

The gel of claim 2 or 26 in which said PEO is present at a concentration of at least about 7 to about 15 percent by weight of said mixture.

Claim 36

Dependent Claim 29 words

The gel of claim 27 in which said poly(vinyl pyrrolidone) is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

Claim 37

Dependent Claim 126 words

A dressing comprising a non-stringy adhesive hydrophilic gel, which gel comprises a homogeneous mixture of (i) water, (ii) at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture and having a weight average molecular weight of at least about 200 kD, and (iii) at least one additive present at a concentration of about 0.001 percent to about 6 percent by weight of said mixture, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 gm/cm and has a peak-force value of at least about 180 grams.

Claim 38

Dependent Claim 126 words

A dressing comprising a non-stringy adhesive hydrophilic gel, which gel comprises a homogeneous mixture of (i) water, (ii) at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture and having a weight average molecular weight of at least about 200 kD, and (iii) at least one additive present at a concentration of about 0.001 percent to about 6 percent by weight of said mixture, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 gm/cm and has a peak-force value of at least about 180 grams.

Claim 39

Dependent Claim 14 words

The dressing of claim 34 in which said water-soluble polymer is poly(ethylene oxides) (PEO).

Claim 40

Dependent Claim 28 words

The dressing of claim 35 in which said PEO is present at a concentration of at least about 7 to about 15 percent by weight of said mixture.

Claim 41

Dependent Claim 30 words

The dressing of claim 34 in which said water-soluble polymer comprises poly(vinyl pyrrolidone) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD.

Claim 42

Dependent Claim 14 words

The dressing of claim 34 in which said additive comprises a physiologically active agent.

Claim 43

Dependent Claim 13 words

The dressing of claim 34 in which said additive comprises a therapeutic drug.

Claim 44

Dependent Claim 13 words

The dressing of claim 34 in which said additive comprises a cosmetic formulation.

Claim 45

Dependent Claim 14 words

The dressing of claim 34 in which said additive comprises at least one preservative.

Claim 46

Dependent Claim 22 words

The dressing of claim 34 in which said water-soluble polymer has a weight average molecular weight of at least about 5,000 kD.

Claim 47

Dependent Claim 21 words

The dressing of claim 34 in which said AED value is at least about 7 to less than about 40 g/cm.

Claim 48

Dependent Claim 29 words

The dressing of claim 34 in which said water-soluble polymer is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

Claim 49

Dependent Claim 155 words

An electrode comprising (a) a conductive non-stringy adhesive hydrophilic gel, which gel comprises a homogeneous mixture of (i) water, (ii) at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture and having a weight average molecular weight of at least about 200 kD, and (iii) an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said gel to an impedance at 60 Hz of less than about 1,000 ohms, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 gm/cm and has a peak-force value of at least about 180 grams; and (b) a suitable conductive member, in intimate contact with said gel, to which may be connected external electrical apparatus.

Claim 50

Dependent Claim 155 words

An electrode comprising (a) a conductive non-stringy adhesive hydrophilic gel, which gel comprises a homogeneous mixture of (i) water, (ii) at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture and having a weight average molecular weight of at least about 200 kD, and (iii) an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said gel to an impedance at 60 Hz of less than about 1,000 ohms, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 gm/cm and has a peak-force value of at least about 180 grams; and (b) a suitable conductive member, in intimate contact with said gel, to which may be connected external electrical apparatus.

Claim 51

Dependent Claim 14 words

The electrode of claim 45 in which said water-soluble polymer is poly(ethylene oxide) (PEO).

Claim 52

Dependent Claim 28 words

The electrode of claim 46 in which said PEO is present at a concentration of at least about 7 to about 15 percent by weight of said mixture.

Claim 53

Dependent Claim 30 words

The electrode of claim 45 in which said water-soluble polymer comprises poly(vinyl pyrrolidone) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD.

Claim 54

Dependent Claim 22 words

The electrode of claim 45 in which said water-soluble polymer has a weight average molecular weight of at least about 5,000 kD.

Claim 55

Dependent Claim 21 words

The electrode of claim 45 in which said AED value is at least about 7 to less than about 40 g/cm.

Claim 56

Dependent Claim 29 words

The electrode of claim 45 in which said water-soluble polymer is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1995-09-01	1996-03-02	1996-09-01	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1999-09-01	2000-03-02	2000-09-01	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2003-09-01	2004-03-02	2004-09-01	$7700.00	Window Closed / Lapsed

Non-stringy adhesive hydrophilic gels

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