US5141868A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for use in chemical test procedures
Assignee: Alere Switzerland GmbH
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Filing: 1989-11-27
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Granted: 1992-08-25
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Expires: 2009-11-27
Abstract
Abstract A specifically-reactive sample-collecting and testing device possessing a cavity or cavities each having a dimension small enough to enable sample liquid to be drawn into the cavity by capillary action, wherein said cavity includes an electrode structure for making measurements of one or more electrically measurable characteristics of the sample, and wherein a surface of a wall of the cavity optionally also carries a coating of a material appropriate to the test to be carried out in the device.
Inventors
- 👤 Ian A. Shanks
- 👤 Alan M. Smith
- 👤 Claes I. Nylander
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 09:58
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/01; G01N21/03; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/327; G01N27/3275; G01N27/3276; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; G01N33/54373; G01N2021/0346
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
121 words
A specifically-reactive sample-collecting and testing device consisting essentially of: a pair of plate elements mounted in facing relation so as to define therebetween at least one cavity, said plate elements being spaced apart so that sample liquid can be drawn into and held within the cavity defined therebetween by capillary action; electrode means for measuring at least one electrically measurable characteristic of a sample liquid disposed in said cavity, said electrode means comprising an electrically conductive coating of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper; and a coating of a material related to a test to be carried out in the device disposed on a surface defining said cavity.
Claim 2
Dependent Claim
121 words
A specifically-reactive sample-collecting and testing device consisting essentially of: a pair of plate elements mounted in facing relation so as to define therebetween at least one cavity, said plate elements being spaced apart so that sample liquid can be drawn into and held within the cavity defined therebetween by capillary action; electrode means for measuring at least one electrically measurable characteristic of a sample liquid disposed in said cavity, said electrode means comprising an electrically conductive coating of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper; and a coating of a material related to a test to be carried out in the device disposed on a surface defining said cavity.
Claim 3
Dependent Claim
16 words
A device according to claim 1, wherein the electrically conductive layer forms a pattern of electrodes.
Claim 4
Dependent Claim
34 words
A device according to claim 1, wherein said material is an immobilised reagent carried on a wall of the cavity, said material being selected from the group consisting of an antigen and an antibody.
Claim 5
Dependent Claim
19 words
A device according to claim 1, in which a surface of the cavity also carries a releasable reagent coating.
Claim 6
Dependent Claim
28 words
A device according to claim 1, wherein the walls of said cavity comprise a member of the group consisting of glass plastics material, soda glass and acrylic plastics.
Claim 7
Dependent Claim
28 words
A device according to claim 1, comprising a bonded structure of plates cemented in spaced parallel relationship to leave a thin planar cavity of capillary dimensions between them.
Claim 8
Dependent Claim
28 words
A device according to claim 1, comprising an external loading surface to which sample liquid can be applied and from which it can be drawn into the cell.
Claim 9
Dependent Claim
22 words
A device according to claim 1, carrying a printed pattern of electrodes on a surface of a wall of the cavity cell.
Claim 10
Dependent Claim
26 words
A device according to claim 1, wherein said surface is a surface of a solid transparent material to enable optical measurements of the capillary cell contents.
Claim 11
Independent Claim
227 words
A method of manufacturing specifically-reactive sample-collecting and testing device consisting essentially of a pair of plate elements mounted in facing relation so as to define therebetween at least one cavity, said plate elements being spaced apart so that sample liquid can be drawn into and held within the cavity defined therebetween by capillary action, electrode means for measuring at least one electrically measurable characteristic of a sample liquid disposed in said cavity, said electrode means being disposed within said cavity, and a coating of a material related to a test to be carried out in the device disposed on a surface defining the said cavity, said method comprising the steps of: forming an immobilized coating on the surface of sheet material defining a said plate element; mounting said coated plate element in facing relation to a second plate element so as to define therebetween at least one cavity of capillary dimensions for collecting and retaining by capillarity a volume of sample liquid in contact with said coating; forming an electrode structure within each said cavity, the electrode structure comprising an electrically conductive coating on at least one inside wall of each cavity of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper; and separating the coated plate element into portions each providing a sample-collecting and testing device.
Claim 12
Independent Claim
227 words
A method of manufacturing specifically-reactive sample-collecting and testing device consisting essentially of a pair of plate elements mounted in facing relation so as to define therebetween at least one cavity, said plate elements being spaced apart so that sample liquid can be drawn into and held within the cavity defined therebetween by capillary action, electrode means for measuring at least one electrically measurable characteristic of a sample liquid disposed in said cavity, said electrode means being disposed within said cavity, and a coating of a material related to a test to be carried out in the device disposed on a surface defining the said cavity, said method comprising the steps of: forming an immobilized coating on the surface of sheet material defining a said plate element; mounting said coated plate element in facing relation to a second plate element so as to define therebetween at least one cavity of capillary dimensions for collecting and retaining by capillarity a volume of sample liquid in contact with said coating; forming an electrode structure within each said cavity, the electrode structure comprising an electrically conductive coating on at least one inside wall of each cavity of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper; and separating the coated plate element into portions each providing a sample-collecting and testing device.
Claim 13
Dependent Claim
15 words
A process according to claim 10, in which the coating is divided into a pattern.
Claim 14
Dependent Claim
81 words
A specifically-reactive sample-collecting and testing device possessing at least one cavity which includes an electrode structure for making measurements of at least one electrically measurable characteristic of the sample, and wherein the cavity has a dimension small enough to enable sample liquid to be drawn into the cavity by capillary action, and wherein the electrode structure comprises an electrically conductive coating of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper.
Claim 15
Dependent Claim
81 words
A specifically-reactive sample-collecting and testing device possessing at least one cavity which includes an electrode structure for making measurements of at least one electrically measurable characteristic of the sample, and wherein the cavity has a dimension small enough to enable sample liquid to be drawn into the cavity by capillary action, and wherein the electrode structure comprises an electrically conductive coating of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper.
Claim 16
Dependent Claim
16 words
A device according to claim 12, wherein the electrically conductive layer forms a pattern of electrodes.
Claim 17
Dependent Claim
34 words
A device according to claim 12, wherein said material is an immobilized reagent carried on a wall of the cavity, said material being selected from the group consisting of an antigen and an antibody.
Claim 18
Dependent Claim
19 words
A device according to claim 12, in which a surface of the cavity also carries a releasable reagent coating.
Claim 19
Dependent Claim
28 words
A device according to claim 12, wherein the walls of said cavity comprise a member of the group consisting of glass plastics material, soda glass and acrylic plastics.
Claim 20
Dependent Claim
28 words
A device according to claim 12, comprising a bonded structure of plates cemented in spaced parallel relationship to leave a thin planar cavity of capillary dimensions between them.
Claim 21
Dependent Claim
28 words
A device according to claim 12, comprising an external loading surface to which sample liquid can be applied and from which it can be drawn into the cell.
Claim 22
Independent Claim
115 words
A method of manufacturing specifically-reactive sample-collecting and testing devices, comprising the steps of: (a) forming in combination with a sheet material which is to provide part of a multiplicity of the devices, a structure which provides for each device of the multiplicity of devices a cavity of capillary dimension for collecting and retaining by capillarity a volume of sample liquid, (b) forming an electrode structure within each cavity, the electrode structure comprising an electrically conductive coating of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper; and (c) separating the sheet material into portions, each providing at least one of the sample-collecting and testing devices.
Claim 23
Independent Claim
115 words
A method of manufacturing specifically-reactive sample-collecting and testing devices, comprising the steps of: (a) forming in combination with a sheet material which is to provide part of a multiplicity of the devices, a structure which provides for each device of the multiplicity of devices a cavity of capillary dimension for collecting and retaining by capillarity a volume of sample liquid, (b) forming an electrode structure within each cavity, the electrode structure comprising an electrically conductive coating of a substance which includes an electrical conductor consisting of at least one of graphite, silver, platinum, gold and copper; and (c) separating the sheet material into portions, each providing at least one of the sample-collecting and testing devices.
Claim 24
Dependent Claim
15 words
A method according to claim 19, in which the coating is divided into a pattern.
Claim 25
Dependent Claim
23 words
A device according to claim 12, carrying a printed pattern of a electrodes on a surface of a wall of the capillary cell.
Claim 26
Dependent Claim
26 words
A method according to claim 20, wherein said surface is a surface of a solid transparent material to enable optical measurements of the capillary cell contents.
Claim 27
Dependent Claim
84 words
A specifically-reactive sample-collecting and testing device possessing at least one cavity which includes an electrode structure for making measurements of at least one electrically measurable characteristic of the sample, and wherein the cavity has a dimension small enough to enable sample liquid to be drawn into the cavity by capillary action, and wherein the electrode structure comprises an electrically conductive coating of a substance which includes an electrical conductor, wherein the electrode means is coated with an enzyme and with an electron transport mediator.
Claim 28
Dependent Claim
84 words
A specifically-reactive sample-collecting and testing device possessing at least one cavity which includes an electrode structure for making measurements of at least one electrically measurable characteristic of the sample, and wherein the cavity has a dimension small enough to enable sample liquid to be drawn into the cavity by capillary action, and wherein the electrode structure comprises an electrically conductive coating of a substance which includes an electrical conductor, wherein the electrode means is coated with an enzyme and with an electron transport mediator.
Claim 29
Dependent Claim
13 words
A device according to claim 24, wherein the electron transport mediator comprises ferrocence.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-25 | 1996-02-24 | 1996-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-25 | 2000-02-24 | 2000-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-25 | 2004-02-24 | 2004-08-25 | $7700.00 | Window Closed / Lapsed |