Amino acid derivatives which have renin inhibiting activity

Claim 2

An amino acid derivative of the general formula ##STR17## wherein R 1 is hydrogen or methyl, R 2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl, t-butylcarbonylmethyl, benzyloxycarbonylmethyl or t-butoxy, R 3 is isobutyl, cyclohexylmethyl or benzyl, A is ##STR18## or --Y--Z and R 4 is alkanoyl, arylcarbonyl, 2,2-dialkylvinyl, --CH═CH--R 7 , ##STR19## in which the dotted line is an additional bond which may or may not be present, R 5 is phenyl, substituted phenyl, benzyl or naphthyl and R 6 is hydrogen, alkoxycarbonylalkyl, alkylcarbonylalkyl, cycloalkylcarbonylalkyl, heterocycloalkylcarbonylalkyl, arylcarbonylalkyl, aminocarbonylalkyl, substituted aminocarbonylalkyl, aminoalkylcarbonylalkyl, substituted aminoalkylcarbonylalkyl, aminoalkylsulphonylalkyl, substituted aminoalkylsulphonylalkyl, alkoxycarbonylhydroxyalkyl, alkylcarbonylhydroxyalkyl, cycloalkylcarbonylhydroxyalkyl, heterocycloalkylcarbonylhydroxyalkyl, arylcarbonylhydroxyalkyl, aminocarbonylhydroxyalkyl, substituted aminocarbonylhydroxyalkyl, dialkoxyphosphoroxyalkyl, diphenyloxyphosphoroxyalkyl, arylalkyl, alkoxycarbonylamino, arylalkoxycarbonylamino, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, arylthioalkyl, arylsulphinylalkyl, arylsulphonylalkyl, arylalkylthioalkyl, arylalkylsulphinylalkyl or arylalkylsulphonylalkyl, with the proviso that R 6 can not be alkoxycarbonylamino or arylalkoxycarbonylamino when R 5 is phenyl, benzyl or α-naphthyl, Y is the bivalent residue of optionally N- and/or α-methylated phenylglycine, cyclohexylglycine, phenylalanine, cyclohexylalanine, 4-fluorophenylalanine, 4-chlorophenylalanine, tyrosine, O-methyltyrosine, α-naphthylalanine or homophenylalanine linked with Z at the N-terminal, Z is acyl, R 7 is aryl, heteroaryl, alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl, R 8 is alkoxy, R 9 is hydrogen or hydroxy and R 10 is azidomethyl, --CH═CH--R 7 , --CH 2 --OR 11 , ##STR20## or --(CH 2 ) n --R 7 in which R 11 is hydrogen, alkyl, arylalkyl, aryl, alkanoyl, arylalkylcarbonyl, heteroarylalkylcarbonyl or alkylcarbamoyl, R 12 and R 13 each independently is hydrogen, alkyl, arylalkyl, heteroarylalkyl, aryl, alkanoyl, alkoxycarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, heteroarylalkylcarbonyl, heterocycloalkylcarbonyl, alkylcarbamoyl or ##STR21## or R 12 and R 13 together with the nitrogen atom to which they are attached are a 5- or 6-membered heterocycle or optionally substituted benzimidazolonyl, n is 0, 1 or 2 and R 14 is hydrogen or arylalkoxycarbonyl, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as a pharmaceutically usable salt of such a compound.

Claim 3

An amino acid derivative as recited in claim 1, wherein R 1 is hydrogen.

Claim 4

An amino acid derivative as recited in claim 1, wherein R 2 is imidazol-2-yl, imidazol-4-yl or thiazol-4-yl.

Claim 5

An amino acid derivative as recited in claim 1, wherein R 3 is cyclohexylmethyl.

Claim 6

An amino acid derivative as recited in claim 1, wherein R 4 is alkanoyl, --CH═CH--R 7 or ##STR22##

Claim 7

An amino acid derivative as recited in claim 5, wherein R 7 is heteroarylalkylaminocarbonyl.

Claim 8

An amino acid derivative as recited in claim 5, wherein R 10 is --CH 2 --OR 11 , ##STR23## or --(CH 2 ) n --R 7 .

Claim 9

An amino acid derivative as recited in claim 7, wherein R 11 is alkanoyl.

Claim 10

An amino acid derivative as recited in claim 7, wherein R 12 is hydrogen.

Claim 11

An amino acid derivative as recited in claim 7, wherein R 13 is alkyl, arylalkyl, heteroarylalkyl or heteroarylalkylcarbonyl.

Claim 12

An amino acid derivative as recited in claim 1, wherein A is Y--Z.

Claim 13

An amino acid derivative as recited in claim 11, wherein Y is the bivalent residue of phenylalanine linked with Z at the N-terminal.

Claim 14

An amino acid derivative as recited in claim 11, wherein Z is the group R a --O--CO-- or the residue of an α-amino acid, said residue being acylated by this group, wherein R a is an optionally substituted, saturated aliphatic hydrocarbon residue with up to 10 carbon atoms or an optionally substituted heteroaromatic hydrocarbon residue with up to 18 carbon atoms.

Claim 15

An amino acid derivative as recited in claim 1, wherein A is ##STR24## and R 5 is phenyl or substituted phenyl.

Claim 16

An amino acid derivative as recited in claim 1, wherein R 6 is alkylcarbonylalkyl, aminoalkylcarbonylalkyl, substituted aminoalkylcarbonylalkyl, aminoalkylsulphonylalkyl, substituted aminoalkylsulphonylalkyl or alkylsulphonylalkyl.

Claim 17

An amino acid derivative as recited in claim 1, wherein R 1 is hydrogen, R 2 is imidazol-4-yl, R 3 is cyclohexylmethyl, R 4 is alkanoyl or ##STR25## in which n is 0 and R 7 is alkylaminocarbonyl, R 12 is hydrogen, R 13 is arylalkyl or heteroarylalkyl, Y is a bivalent residue of phenylalanine linked with Z at the N-terminal and Z is the group R a --O--CO-- or the residue of proline which is acylated by this group, wherein R a is a saturated, aliphatic hydrocarbon residue with up to 6 carbon atoms.

Claim 18

An amino acid derivative selected from the group consisting of (S)-N-[[(1S,2S,4R)-4-[(butylcarbamoyl)methyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamido]imidazole-4-propionamide, t-butyl [(S)-α-[[(S)-1-[[(1S, 2S,4R)-4-[(butylcarbamoyl)methyl]]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamate, (S)-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-oxodecyl]-.alpha.-[(R)-α-(3,3-dimethyl-2-oxobutyl]hydrocinnamamido]imidazole-4-propionamide, (S)-N-[(1S,2S,4S,E)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-6-[(2-pyridylmethyl)carbamoyl]-5-hexenyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamido]imidazole-4-propionamide, t-butyl [(S)-α-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-6-(propionyloxy)hexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamate, t-butyl (R)-2-[[(S)-α-[[(R and S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl]-2-hydroxy-4-isopropyl-6-(pivaloyloxy)hexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamoyl]-1-pyrrolidinecarboxylate, (2S or R,3S,5S,6S)-6-(Boc-D-Pro-Phe-His-NH)-7-cyclohexyl-3-isopropyl-1-(phenethylamino)-2,5-heptanediol, (2R or S,3S,5S,6S)-6(Boc-D-Pro-Phe-His-NH)-7-cyclohexyl-3-isopropyl-1-(phenethylamino)-2,5-heptanediol, and (2RS,3S,5S,6S)-6-(Boc-D-Pro-Phe-His-NH)-7-cyclohexyl-3-isopropyl-1-[(2-pyridylmethyl)amino]-2,5-heptanediol.

Claim 19

An amino acid derivative selected from the group consisting of (S)-N-[[(1S,2S,4R)-4-[(butylcarbamoyl)methyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamido]imidazole-4-propionamide, t-butyl [(S)-α-[[(S)-1-[[(1S, 2S,4R)-4-[(butylcarbamoyl)methyl]]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamate, (S)-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-oxodecyl]-.alpha.-[(R)-α-(3,3-dimethyl-2-oxobutyl]hydrocinnamamido]imidazole-4-propionamide, (S)-N-[(1S,2S,4S,E)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-6-[(2-pyridylmethyl)carbamoyl]-5-hexenyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamido]imidazole-4-propionamide, t-butyl [(S)-α-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-6-(propionyloxy)hexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamate, t-butyl (R)-2-[[(S)-α-[[(R and S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl]-2-hydroxy-4-isopropyl-6-(pivaloyloxy)hexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamoyl]-1-pyrrolidinecarboxylate, (2S or R,3S,5S,6S)-6-(Boc-D-Pro-Phe-His-NH)-7-cyclohexyl-3-isopropyl-1-(phenethylamino)-2,5-heptanediol, (2R or S,3S,5S,6S)-6(Boc-D-Pro-Phe-His-NH)-7-cyclohexyl-3-isopropyl-1-(phenethylamino)-2,5-heptanediol, and (2RS,3S,5S,6S)-6-(Boc-D-Pro-Phe-His-NH)-7-cyclohexyl-3-isopropyl-1-[(2-pyridylmethyl)amino]-2,5-heptanediol.

Claim 20

A compound selected from the group consisting of: ##STR26## wherein R 1 is hydrogen or methyl, R 2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl, t-butylcarbonylmethyl, benzyloxycarbonylmethyl or t-butoxy, R 3 is isobutyl, cyclohexylmethyl or benzyl, A is ##STR27## or --Y--Z and R 4 is alkanoyl, arylcarbonyl, 2,2-dialkylvinyl, --CH═CH--R 7 , ##STR28## wherein the dotted line can be an additional bond which may or may not be present R 5 is phenyl, substituted phenyl, benzyl or naphthyl and R 6 is hydrogen, alkoxycarbonylalkyl, alkylcarbonylalkyl, cycloalkylcarbonylalkyl, heterocycloalkylcarbonylalkyl, arylcarbonylalkyl, aminocarbonylalkyl, substituted aminocarbonylalkyl, aminoalkylcarbonylalkyl, substituted aminoalkylcarbonylalkyl, aminoalkylsulphonylalkyl, substituted aminoalkylsulphonylalkyl, alkoxycarbonylhydroxyalkyl, alkylcarbonylhydroxyalkyl, cycloalkylcarbonylhydroxyalkyl, heterocycloalkylcarbonylhydroxyalkyl, arylcarbonylhydroxyalkyl, aminocarbonylhydroxyalkyl, substituted aminocarbonylhydroxyalkyl, dialkoxyphosphoroxyalkyl, diphenyloxyphosphoroxyalkyl, arylalkyl, alkoxycarbonylamino, arylalkoxycarbonylamino, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, arylthioalkyl, arylsulphinylalkyl, arylsulphonylalkyl, arylalkylthioalkyl, arylalkylsulphinylalkyl or arylalkylsulphonylalkyl, with the proviso that R 6 can not be alkoxycarbonylamino or arylalkoxycarbonylamino when R 5 is phenyl, benzyl or α-naphthyl, Y is the bivalent residue of optionally N- and/or α-methylated phenylglycine, cyclohexylglycine, phenylalanine, cyclohexylalanine, 4-fluorophenylalanine, 4-chlorophenylalanine, tyrosine, O-methyltyrosine, α-naphthylalanine or homophenylalanine linked with Z at the N-terminal, Z is acyl, R 7 is alkyl, aryl, heteroaryl, alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl, R 8 is alkoxy, R 9 is hydrogen or hydroxy and R 10 is azidomethyl, --CH═CH--R 7 , --CH 2 --OR 11 , ##STR29## or --(CH 2 ) n --R 7 wherein R 11 is hydrogen, alkyl, arylalkyl, aryl, alkanoyl, arylalkylcarbonyl, heteroarylalkylcarbonyl or alkylcarbamoyl, R 12 and R 13 each independently is hydrogen, alkyl, arylalkyl, heteroarylalkyl, aryl, alkanoyl, alkoxycarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, heteroarylalkylcarbonyl, heterocycloalkylcarbonyl, alkylcarbamoyl or ##STR30## or R 12 and R 13 together with the nitrogen atom to which they are attached are a 5- or 6-membered heterocycle or optionally substituted benzimidazolonyl, n is O, 1 or 2 and R 14 is hydrogen or arylalkoxycarbonyl, R 22 is N-protected imidazol-2-yl, imidazol-4-yl or pyrazol-3-yl, B is an amino protecting group, R 15 is --CH 2 --OR 11 , alkylaminocarbonylethyl, arylalkylaminocarbonylethyl or heteroarylalkylaminocarbonylethyl and R 16 is an O-protecting group or R 15 is alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl and R 16 is hydrogen and R 42 is alkanoyl, arylcarbonyl, 2,2-dialkylvinyl --CH═CH--R 7 , ##STR31## with the proviso that in ##STR32## R 9 is hydrogen when R 10 is --CH 2 --OR 11 or --(CH 2 ) n --R 7 in which n is O or 2 and R 7 is alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl, R 18 is hydrogen and R 19 is hydroxymethyl, carboxyl, formyl, 2-ethoxycarbonylvinyl, 2-carboxyvinyl, carboxymethyl or the groups --OX or --CH 2 OX or R 18 is hydroxy and R 19 is cyano or carboxymethyl, R 20 is 2-ethoxycarbonylvinyl or 2-carboxyvinyl, R 21 is hydroxymethyl, carboxyl, formyl or the group --CH═CH--R 72 , R 161 is an O-protecting group, X is p-tolylsulphonyl, methylsulphonyl, trifluoromethylsulphonyl or p-bromobenzenesulphonyl and R 72 is alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl.

Claim 21

A compound selected from the group consisting of: ##STR26## wherein R 1 is hydrogen or methyl, R 2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl, t-butylcarbonylmethyl, benzyloxycarbonylmethyl or t-butoxy, R 3 is isobutyl, cyclohexylmethyl or benzyl, A is ##STR27## or --Y--Z and R 4 is alkanoyl, arylcarbonyl, 2,2-dialkylvinyl, --CH═CH--R 7 , ##STR28## wherein the dotted line can be an additional bond which may or may not be present R 5 is phenyl, substituted phenyl, benzyl or naphthyl and R 6 is hydrogen, alkoxycarbonylalkyl, alkylcarbonylalkyl, cycloalkylcarbonylalkyl, heterocycloalkylcarbonylalkyl, arylcarbonylalkyl, aminocarbonylalkyl, substituted aminocarbonylalkyl, aminoalkylcarbonylalkyl, substituted aminoalkylcarbonylalkyl, aminoalkylsulphonylalkyl, substituted aminoalkylsulphonylalkyl, alkoxycarbonylhydroxyalkyl, alkylcarbonylhydroxyalkyl, cycloalkylcarbonylhydroxyalkyl, heterocycloalkylcarbonylhydroxyalkyl, arylcarbonylhydroxyalkyl, aminocarbonylhydroxyalkyl, substituted aminocarbonylhydroxyalkyl, dialkoxyphosphoroxyalkyl, diphenyloxyphosphoroxyalkyl, arylalkyl, alkoxycarbonylamino, arylalkoxycarbonylamino, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, arylthioalkyl, arylsulphinylalkyl, arylsulphonylalkyl, arylalkylthioalkyl, arylalkylsulphinylalkyl or arylalkylsulphonylalkyl, with the proviso that R 6 can not be alkoxycarbonylamino or arylalkoxycarbonylamino when R 5 is phenyl, benzyl or α-naphthyl, Y is the bivalent residue of optionally N- and/or α-methylated phenylglycine, cyclohexylglycine, phenylalanine, cyclohexylalanine, 4-fluorophenylalanine, 4-chlorophenylalanine, tyrosine, O-methyltyrosine, α-naphthylalanine or homophenylalanine linked with Z at the N-terminal, Z is acyl, R 7 is alkyl, aryl, heteroaryl, alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl, R 8 is alkoxy, R 9 is hydrogen or hydroxy and R 10 is azidomethyl, --CH═CH--R 7 , --CH 2 --OR 11 , ##STR29## or --(CH 2 ) n --R 7 wherein R 11 is hydrogen, alkyl, arylalkyl, aryl, alkanoyl, arylalkylcarbonyl, heteroarylalkylcarbonyl or alkylcarbamoyl, R 12 and R 13 each independently is hydrogen, alkyl, arylalkyl, heteroarylalkyl, aryl, alkanoyl, alkoxycarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, heteroarylalkylcarbonyl, heterocycloalkylcarbonyl, alkylcarbamoyl or ##STR30## or R 12 and R 13 together with the nitrogen atom to which they are attached are a 5- or 6-membered heterocycle or optionally substituted benzimidazolonyl, n is O, 1 or 2 and R 14 is hydrogen or arylalkoxycarbonyl, R 22 is N-protected imidazol-2-yl, imidazol-4-yl or pyrazol-3-yl, B is an amino protecting group, R 15 is --CH 2 --OR 11 , alkylaminocarbonylethyl, arylalkylaminocarbonylethyl or heteroarylalkylaminocarbonylethyl and R 16 is an O-protecting group or R 15 is alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl and R 16 is hydrogen and R 42 is alkanoyl, arylcarbonyl, 2,2-dialkylvinyl --CH═CH--R 7 , ##STR31## with the proviso that in ##STR32## R 9 is hydrogen when R 10 is --CH 2 --OR 11 or --(CH 2 ) n --R 7 in which n is O or 2 and R 7 is alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl, R 18 is hydrogen and R 19 is hydroxymethyl, carboxyl, formyl, 2-ethoxycarbonylvinyl, 2-carboxyvinyl, carboxymethyl or the groups --OX or --CH 2 OX or R 18 is hydroxy and R 19 is cyano or carboxymethyl, R 20 is 2-ethoxycarbonylvinyl or 2-carboxyvinyl, R 21 is hydroxymethyl, carboxyl, formyl or the group --CH═CH--R 72 , R 161 is an O-protecting group, X is p-tolylsulphonyl, methylsulphonyl, trifluoromethylsulphonyl or p-bromobenzenesulphonyl and R 72 is alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl.

Claim 22

A process for the manufacture of a compound in accordance with claim 1, which process comprises a) reacting a compound of the general formula ##STR33## wherein R 1 , R 2 , R 3 and R 4 have the significance given in claim 1, with an acylating agent yielding the group ##STR34## wherein R 5 , R 6 , Y, Z and the dotted line have the significance given in claim 1, or b) reacting a compound of the general formula ##STR35## wherein R 3 and R 4 have the significance given in claim 1, with a compound of the general formula ##STR36## wherein R 1 , R 2 and A have the significance given in claim 1, or an activated derivative thereof, or c) reacting a compound corresponding to formula I, but in which Z is hydrogen and the remaining symbols have the significance given in claim 1 with an acylated amino acid or an acylated dipeptide, or d) for the manufacture of a compound of formula I in which R 2 is imidazol-2-yl, imidazol-4-yl or pyrazol-3-yl and/or R 12 is hydrogen, cleaving off the N-protecting group and/or the substituent R 12 from a compound of the general formula ##STR37## wherein R 21 is ethyl, propyl, isopropyl, thiazolyl-4-yl, thien-2-yl, ethoxycarbonyl, t-butyl-carbonylmethyl, benzyloxycarbonylmethyl, t-butoxy or optionally N-protected imidazol-2-yl, imidazol-4-yl or pyrazol-3-yl and R 41 is alkanoyl, arylcarbonyl, 2,2-dialkylvinyl, --CH═CH--R 7 , ##STR38## in which R 7 is aryl, heteroaryl, alkylaminocarbonyl, arylalkylaminocarbonyl or heteroarylalkylaminocarbonyl, R 8 is alkoxy, R 9 is hydrogen or hydroxy and R 10 is azidomethyl, --CH═CH--R 7 , --CH 2 --OR 11 , ##STR39## or --(CH 2 ) n --R 7 in which R 11 is hydrogen, alkyl, arylalkyl, aryl, alkanoyl, arylalkylcarbonyl, heteroarylalkylcarbonyl or alkylcarbamoyl, R 12 and R 13 each independently is hydrogen, alkyl, arylalkyl, heteroarylalkyl, aryl, alkanoyl, alkoxycarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, heteroarylalkylcarbonyl, heterocycloalkylcarbonyl, alkylcarbamoyl or ##STR40## or R 12 and R 13 together with the nitrogen atom to which they are attached are a 5- or 6-membered heterocycle or optionally substituted benzimidazolonyl, n is O, 1 or 2 and R 14 is hydrogen or arylalkoxycarbonyl, and the remaining symbols have the significance given in claim 1, with the proviso that R 21 is N-protected imidazol-2-yl, imidazol-4-yl or pyrazol-3-yl and/or R 41 is ##STR41## in which R 10 is ##STR42## and R 12 is readily cleavable arylalkyl, alkoxycarbonyl or arylalkoxycarbonyl, and e) if desired, separating a mixture of diastereomeric racemates into the diastereomeric racemates or optically pure diastereomers, and/or f) if desired, separating a mixture of diastereomers into the optically pure diastereomers, and/or g) if desired, converting a compound obtained into a pharmaceutically usable salt.

Claim 23

A compound composition for the control or prevention of high blood pressure and cardiac insufficiency, containing an amino acid derivative as recited in claim 1 and a physiologically acceptable carrier.

Claim 24

A process for treating high blood pressure and cardiac insufficiency comprising administering a therapeutically effective amount of an amino acid derivative as recited in claim 1 and a physiologically acceptable carrier.