US5138052A
Expired / Lapsed
US
⏱️ 0.0 years remaining
L-683,590 microbial transformation product
Assignee: Merck and Co Inc
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Filing: 1991-03-05
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Granted: 1992-08-11
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Expires: 2011-03-05
Abstract
Abstract Described is a new L-679,934 (FK-506) antagonist, L-686,292, a C-15, C-31 bisdemethylated, derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide reverses the immunosuppressant action of L-679,934 (FK-506), and can be used diagnostically as a tool to determine the presence of FK-506 macrolide type immunosuppressants in natural product broths, distinguishing such immunosuppressants from other chemical families such as the cycloporins.
Inventors
- 👤 Shieh-Shung T. Chen
- 👤 Linda S. Wicker
- 👤 Byron H. Arison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:29
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/12; C07D498/18; C07H; C07H19/00; C07H19/01; C12; C12P; C12P17/00; C12P17/18; C12P17/188
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
30 words
A compound which exhibits: a proton nuclear magnetic spectrogram and molecular structure as depicted in FIG. 1, and a molecular weight of 763 as determined by electron impact mass spectroscopy.
Claim 2
Dependent Claim
30 words
A compound which exhibits: a proton nuclear magnetic spectrogram and molecular structure as depicted in FIG. 1, and a molecular weight of 763 as determined by electron impact mass spectroscopy.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-11 | 1996-02-10 | 1996-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-11 | 2000-02-10 | 2000-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-11 | 2004-02-10 | 2004-08-11 | $7700.00 | Window Closed / Lapsed |