US5128318A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reconstituted HDL particles and uses thereof
Assignee: Rogosin Institute Inc
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Filing: 1988-10-27
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Granted: 1992-07-07
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Expires: 2008-10-27
Abstract
Abstract A reconstituted high density lipoprotein containing particle is disclosed. The particle is useful in removing excess lipid soluble material from a subject to which it is administered, as well as in delivery of lipid soluble pharmaceuticals to subjects or patients.
Inventors
- 👤 Daniel M. Levine
- 👤 Sanford R. Simon
- 👤 Bruce R. Gordon
- 👤 Thomas S. Parker
- 👤 Stuart D. Saal
- 👤 Albert L. Rubin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K9/00; A61K9/10; A61K9/127; A61K9/1275; Y; Y10; Y10S; Y10S436/00; Y10S436/829
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
50 words
Method for treating a subject for endotoxin caused toxicity comprising administering to said subject an amount of a reconstituted, cholesterol free particle which contains (i) an HDL associated apolipoprotein and (ii) a lipid in which the endotoxin causing said toxicity is soluble sufficient to alleviate toxicity caused by said endotoxin.
Claim 2
Dependent Claim
50 words
Method for treating a subject for endotoxin caused toxicity comprising administering to said subject an amount of a reconstituted, cholesterol free particle which contains (i) an HDL associated apolipoprotein and (ii) a lipid in which the endotoxin causing said toxicity is soluble sufficient to alleviate toxicity caused by said endotoxin.
Claim 3
Dependent Claim
51 words
Method for treating a subject for endotoxin caused toxicity comprising administering to said subject an amount of a reconstituted particle containing (i) cholesterol, (ii) an HDL associated apolipoprotein, and (iii) a lipid in which endotoxin causing said toxicity is soluble, in an amount sufficient to alleviate toxicity caused by said endotoxin.
Claim 4
Dependent Claim
51 words
Method for treating a subject for endotoxin caused toxicity comprising administering to said subject an amount of a reconstituted particle containing (i) cholesterol, (ii) an HDL associated apolipoprotein, and (iii) a lipid in which endotoxin causing said toxicity is soluble, in an amount sufficient to alleviate toxicity caused by said endotoxin.
Claim 5
Dependent Claim
21 words
Method of claim 1, wherein said reconstituted particle consists of said high density lipoprotein associated apolipoprotein associated apolipoprotein is apolipoprotein AI.
Claim 6
Dependent Claim
14 words
Method of claim 1, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AII.
Claim 7
Dependent Claim
14 words
Method of claim 1, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AII.
Claim 8
Dependent Claim
14 words
Method of claim 2, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AI.
Claim 9
Dependent Claim
14 words
Method of claim 2, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AII.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-07 | 1996-01-06 | 1996-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-07 | 2000-01-06 | 2000-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-07 | 2004-01-06 | 2004-07-07 | $7700.00 | Window Closed / Lapsed |