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US5128103A Expired / Lapsed US ⏱️ 0.0 years remaining

Apparatus for automatically processing magnetic solid phase reagents

Assignee: Siemens Healthcare Diagnostics Inc
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Filing: 1990-12-14
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Granted: 1992-07-07
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Expires: 2010-12-14
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Abstract

Abstract An automatic chemistry system having a wheel for mounting reaction vessels is provided with a programmable permanent magnet which is selectively positioned adjacent a reaction vessel to separate magnetizable particles in the vessel from the vessels liquid contents. This facilitates performing heterogeneous immunoassays.

Inventors

  • 👤 Chi-Chin Wang
  • 👤 Robert T. McKeever
  • 👤 Marshall L. Salyers

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 14:04
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/0098; G01N35/00584; G01N35/00722; G01N35/00732; G01N2035/00742; G01N2035/00752; G01N35/02; G01N35/021; G01N2035/023; G01N35/04; G01N2035/0439; G01N2035/0441; G01N2035/0446; G01N2035/046; G01N2035/0465; G01N35/10; G01N2035/1027; G01N2035/1048; G01N2035/1058; G01N35/1065; G01N2035/1076; G01N35/1081; G01N35/1083; G01N2035/1086; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 177 words
An automatic apparatus for use in assays for separating magnetic particles from a liquid phase, the apparatus comprising: a plurality of reaction vessels for holding magnetic particles dispersed in a liquid phase, a reaction vessel mounting wheel for moving the plurality of reaction vessels in sequence past at least one processing position, probe means for dispensing liquid into and withdrawing liquid from the plurality of reaction vessels, a reaction monitoring arm mounted for relative movement with respect to the reaction vessel mounting wheel and to be positioned with its periphery adjacent any of the plurality of reaction vessels, a detector positioned on the reaction monitoring arm radially outside of the plurality reaction vessels, the reaction monitoring arm being operable to direct a beam of interrogating radiation through each plurality of reaction vessles to the detector, and coupling means coupled to the reaction monitoring arm for selectively positioning a first magnet adjacent the location of the beam of interrogating radiation, but spaced therefrom by the distance separating adjacent plurality of reaction vessels on the reaction vessel mounting wheel.
Claim 2
Dependent Claim 177 words
An automatic apparatus for use in assays for separating magnetic particles from a liquid phase, the apparatus comprising: a plurality of reaction vessels for holding magnetic particles dispersed in a liquid phase, a reaction vessel mounting wheel for moving the plurality of reaction vessels in sequence past at least one processing position, probe means for dispensing liquid into and withdrawing liquid from the plurality of reaction vessels, a reaction monitoring arm mounted for relative movement with respect to the reaction vessel mounting wheel and to be positioned with its periphery adjacent any of the plurality of reaction vessels, a detector positioned on the reaction monitoring arm radially outside of the plurality reaction vessels, the reaction monitoring arm being operable to direct a beam of interrogating radiation through each plurality of reaction vessles to the detector, and coupling means coupled to the reaction monitoring arm for selectively positioning a first magnet adjacent the location of the beam of interrogating radiation, but spaced therefrom by the distance separating adjacent plurality of reaction vessels on the reaction vessel mounting wheel.
Claim 3
Dependent Claim 22 words
The automatic apparatus of claim 1 wherein a magnet is mounted on the detector radially outside of the plurality of reaction vessels.
Claim 4
Dependent Claim 44 words
The automatic apparatus of claim 1 which includes second and third magnets; and wherein the coupling means positions the second and third magnets adjacent the first magnet, whereby the plurality of reaction vessels are sequentially positioned and are simultaneously subjected to a magnetic field.
Claim 5
Dependent Claim 22 words
The automatic apparatus of claim 3 wherein the coupling means is a bracket secured to the periphery of the reaction monitoring arm.
Claim 6
Dependent Claim 30 words
The automatic apparatus of claim 3 wherein the probe means is operable to transfer liquid in a vessel subjected to any magnet to another vessel free of the magnetic particles.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1995-07-07 1996-01-06 1996-07-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1999-07-07 2000-01-06 2000-07-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2003-07-07 2004-01-06 2004-07-07 $7700.00 Window Closed / Lapsed

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