US5126433A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Soluble forms of the t cell surface protein cd4
Assignee: Columbia University
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Filing: 1987-10-23
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Granted: 1992-06-30
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Expires: 2007-10-23
Abstract
Abstract A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
Inventors
- 👤 Paul J. Maddon
- 👤 Leonard Chess
- 👤 Richard Axel
- 👤 Robin Weiss
- 👤 Dan R. Littman
- 👤 J. Steven McDougal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 10:13
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/70; C12Q1/701; C12Q1/702; C12Q1/703; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/70503; C07K14/70514; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
9 words
Glycosylated sT4 consisting of the amino acid sequence: ##STR2##
Claim 2
Dependent Claim
9 words
Glycosylated sT4 consisting of the amino acid sequence: ##STR2##
Claim 3
Dependent Claim
6 words
Purified, glycosylated sT4 of claim 1.
References Cited (Backward Citations)
US4621054A
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US4816567A
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US4520113A
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US4663436A
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US4761371A
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US4629783A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-30 | 1995-12-30 | 1996-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-30 | 1999-12-30 | 2000-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-30 | 2003-12-30 | 2004-06-30 | $7700.00 | Window Closed / Lapsed |