US5124437A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Galactosamine substitute of poly-ω-substituted-L-glutamic acid (or aspartic acid)
Assignee: Astellas Pharma Inc
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Filing: 1991-04-23
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Granted: 1992-06-23
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Expires: 2011-04-23
Abstract
Abstract A galactosamine substituted poly-ω-alkyl (or benzyl)-L-glutamic acid (or aspartic acid) is provided and comprises a polypeptide having the recurring unit represented by the formula: ##STR1## wherein X has a value of 60 to 250; n is 1 or 2; and R represents a lower alkyl group or benzyl group, in which a part or all of the peptide in said polypeptide is substituted by an ω-galactosamyl-L-glutamic acid (or aspartic acid) residue represented by the general formula: ##STR2## wherein n is as indicated.
Inventors
- 👤 Toshihiro Akaike
- 👤 Ichirou Kitada
- 👤 Megumi Kunou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:46
CPC Classifications
C; C07; C07K; C07K14/00; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
85 words
A galactosamine substituted poly-ω-alkyl or benzyl-L-glutamic acid or aspartic acid comprising a polypeptide having a recurring unit represented by the general formula: ##STR10## wherein X has a value of 60 to 250; n is 1 or 2; and R represents a C 1-4 alkyl group or benzyl group, in which a part or all of said recurring units in said polypeptide are substituted by an ω-galactosamyl-L-glutamic acid or aspartic acid residue represented by the formula: ##STR11## wherein n has the same value as described above.
Claim 2
Dependent Claim
85 words
A galactosamine substituted poly-ω-alkyl or benzyl-L-glutamic acid or aspartic acid comprising a polypeptide having a recurring unit represented by the general formula: ##STR10## wherein X has a value of 60 to 250; n is 1 or 2; and R represents a C 1-4 alkyl group or benzyl group, in which a part or all of said recurring units in said polypeptide are substituted by an ω-galactosamyl-L-glutamic acid or aspartic acid residue represented by the formula: ##STR11## wherein n has the same value as described above.
Claim 3
Dependent Claim
131 words
A partially galactosamylated ω-alkyl or benzyl-L-glutamic acid or aspartic acid linear polymer comprising, as recurring units, an ω-alkyl or benzyl-L-glutamic acid or aspartic acid residue: ##STR12## wherein n is 1 or 2 and R represents a C 1-4 alkyl group or benzyl group; and L-glutamic acid or aspartic acid residue: ##STR13## wherein n has the same significance as described above; and, an ω-galactosamyl-L-glutamic acid (or aspartic acid) residue: ##STR14## wherein n has the same significance as described above, and said polymer having from 60 to 250 recurring units, a molecular weight of 8,000 to 71,000 and the following ratio of the respective recurring units: an ω-alkyl or benzyl-L-glutamic acid or aspartic acid residue: 0-97% an L-glutamic acid or aspartic acid residue: 0-87% and an ω-galactosamyl-L-glutamic acid or aspartic acid residue: 3-100%.
Claim 4
Dependent Claim
131 words
A partially galactosamylated ω-alkyl or benzyl-L-glutamic acid or aspartic acid linear polymer comprising, as recurring units, an ω-alkyl or benzyl-L-glutamic acid or aspartic acid residue: ##STR12## wherein n is 1 or 2 and R represents a C 1-4 alkyl group or benzyl group; and L-glutamic acid or aspartic acid residue: ##STR13## wherein n has the same significance as described above; and, an ω-galactosamyl-L-glutamic acid (or aspartic acid) residue: ##STR14## wherein n has the same significance as described above, and said polymer having from 60 to 250 recurring units, a molecular weight of 8,000 to 71,000 and the following ratio of the respective recurring units: an ω-alkyl or benzyl-L-glutamic acid or aspartic acid residue: 0-97% an L-glutamic acid or aspartic acid residue: 0-87% and an ω-galactosamyl-L-glutamic acid or aspartic acid residue: 3-100%.
References Cited (Backward Citations)
JPS6042335A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-23 | 1995-12-23 | 1996-06-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-23 | 1999-12-23 | 2000-06-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-23 | 2003-12-23 | 2004-06-23 | $7700.00 | Window Closed / Lapsed |