US5124340A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of calcium channel blocker to prevent cocaine induced craving and reinforcement
Assignee: United States Department of Health and Human Services
•
Filing: 1989-06-28
•
Granted: 1992-06-23
•
Expires: 2009-06-28
Abstract
Abstract A method of treating cocaine addiction by administering to a patient in need thereof, an anti-cocaine addicting effective amount of a calcium channel blocking agent.
Inventors
- 👤 Jerome H. Jaffe
- 👤 Karen Kumor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 11:03
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
26 words
A method of treating cocaine addiction by administering to a patient in need thereof, an anti-cocaine addicting effective amount of a dihydropyridine calcium channel blocking agent.
Claim 2
Independent Claim
26 words
A method of treating cocaine addiction by administering to a patient in need thereof, an anti-cocaine addicting effective amount of a dihydropyridine calcium channel blocking agent.
Claim 3
Dependent Claim
28 words
The method according to claim 1 wherein said dihydropyridine is selected from the group consisting of nifedipine, nimodipine, nitrendipine, nilvadipine, nicardipine, nisoldipine, Bay K 8644, isradipine, and felodipine.
Claim 4
Dependent Claim
21 words
The method according to claim 1 wherein said calcium channel blocking agent is administered prior to, during, and after cocaine use.
Claim 5
Dependent Claim
25 words
The method according to claim 2 wherein said calcium channel blocking agent is nifedipine and said anti-cocaine addicting effective amount is 0.5 to 1.5 mg/kg/day.
Claim 6
Dependent Claim
21 words
The method according to claim 4 wherein said anti-cocaineXaddicting effective amount administered is 1 to 30 mg, three times a day.
Claim 7
Dependent Claim
15 words
The method according to claim 1 wherein said calcium channel blocking agent is administered orally.
Claim 8
Dependent Claim
15 words
The method according to claim 1 wherein said calcium channel blocking agent is administered parenterally.
Claim 9
Dependent Claim
20 words
The method according to claim 1 wherein said calcium channel blocking agent is administered by way of an osmotic pump.
Claim 10
Dependent Claim
18 words
The method according to claim 6 wherein said oral administration is by way of a sustained release formulation.
Claim 11
Dependent Claim
21 words
The method according to claim 1 wherein said calcium channel blocking agent is administered for a period of about 8-16 weeks.
Claim 12
Independent Claim
32 words
A method for the prophylactic treatment of cardiac toxicity due to cocaine comprising administering to a patient in need thereof an anti-cocaine cardiotoxic effective amount of a dihydropyridine calcium channel blocking agent.
Claim 13
Independent Claim
32 words
A method for the prophylactic treatment of cardiac toxicity due to cocaine comprising administering to a patient in need thereof an anti-cocaine cardiotoxic effective amount of a dihydropyridine calcium channel blocking agent.
Claim 14
Dependent Claim
28 words
The method according to claim 11 wherein said dihydropyridine is selected from the group consisting of nifedipine, nimodipine, nitrendipine, nilvadipine, nicardipine, nisoldipine, Bay K 8644, isradipine, and felodipine.
Claim 15
Dependent Claim
13 words
The method according to claim 12 wherein said calcium channel blocker is nifedipine.
Claim 16
Dependent Claim
17 words
The method according to claim 13 wherein said anti-cocaine cardiotoxic effective amount is 0.5 to 1.5 mg/kg/day.
Claim 17
Dependent Claim
22 words
The method according to claim 13 wherein said anti-cocaine cardiotoxic effective amount administered is 1 to 30 mg, three times a day.
Claim 18
Dependent Claim
15 words
The method according to claim 11 wherein said calcium channel blocking agent is administered orally.
Claim 19
Dependent Claim
15 words
The method according to claim 11 wherein said calcium channel blocking agent is administered parenterally.
Claim 20
Dependent Claim
20 words
The method according to claim 11 wherein said calcium channel blocking agent is administered by way of an osmotic pump.
Claim 21
Dependent Claim
18 words
The method according to claim 16 wherein said oral administration is by way of a sustained release formulation.
References Cited (Backward Citations)
US4797410A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-23 | 1995-12-23 | 1996-06-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-23 | 1999-12-23 | 2000-06-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-23 | 2003-12-23 | 2004-06-23 | $7700.00 | Window Closed / Lapsed |