US5116116A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmological diagnosis method
Assignee: Kowa Co Ltd
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Filing: 1990-03-05
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Granted: 1992-05-26
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Expires: 2010-03-05
Abstract
Abstract An ophthalmological diagnosis method is provided in which a laser beam is projected at a region of the eye fundus to produce a laser speckle pattern formed by light scattered from tissues of the eye fundus. Movement of the speckle pattern is detected to produce a speckle signal which is photon-counted as photoelectric pulses per unit sampling time. The counted data are stored in a computer memory as time series data over one measurement time. The stored data are then processed to provide a correlation function using different delay times and are also divided per unit time. For the divided data, the correlation function or variance is calculated for each unit time. Such an arrangement makes it possible to accomplish accurate evaluation even when there is movement of the eye fundus and thus ensures that measurement data are fully utilized to provide accurate ophthalmological diagnosis.
Inventors
- 👤 Yoshihisa Aizu
- 👤 Kohji Ogino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:09
CPC Classifications
A; A61; A61B; A61B3/00; A61B3/10; A61B3/12; A61B3/1225; A61B3/1233; G; G02; G02B; G02B27/00; G02B27/48
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
186 words
An ophthalmological diagnosis method comprising the steps of: projecting a laser beam of prescribed diameter at a region of an eye to produce a laser speckle pattern formed by light scattered from tissues of the eye fundus; photoelectrically detecting movement of the laser speckle pattern through a detecting aperture as a fluctuation in the light intensity of the speckles to produce a speckle signal corresponding to the detected movement; measuring a photon correlation function of the speckle signal to determine a blood flow state in the eye fundus tissue from the measured photon correlation function; photoelectrically counting count data corresponding to the laser speckle pattern as photoelectric pulses per unit sampling time; storing the count data in a computer memory as time series data over a measurement time; dividing the stored count data by the unit sampling time; and processing the count data divided by the unit sampling time to calculate a variance for each of the count data and classifying the count data as blood vessel signal data, indeterminate signal data, or surrounding tissue signal data by comparing the calculated variance with two reference values.
Claim 2
Dependent Claim
186 words
An ophthalmological diagnosis method comprising the steps of: projecting a laser beam of prescribed diameter at a region of an eye to produce a laser speckle pattern formed by light scattered from tissues of the eye fundus; photoelectrically detecting movement of the laser speckle pattern through a detecting aperture as a fluctuation in the light intensity of the speckles to produce a speckle signal corresponding to the detected movement; measuring a photon correlation function of the speckle signal to determine a blood flow state in the eye fundus tissue from the measured photon correlation function; photoelectrically counting count data corresponding to the laser speckle pattern as photoelectric pulses per unit sampling time; storing the count data in a computer memory as time series data over a measurement time; dividing the stored count data by the unit sampling time; and processing the count data divided by the unit sampling time to calculate a variance for each of the count data and classifying the count data as blood vessel signal data, indeterminate signal data, or surrounding tissue signal data by comparing the calculated variance with two reference values.
Claim 3
Dependent Claim
28 words
An ophthalmological diagnosis method as set forth in claim 1, wherein a correlation function is calculated for each of the count data divided by the unit sampling time.
Claim 4
Dependent Claim
28 words
An opthalmological diagnosis method as set forth in claim 1, wherein a correlation time is calculated for each of the count data divided by the unit sampling time.
Claim 5
Dependent Claim
29 words
An opthalmological diagnosis method as set forth in claim 3, wherein the inverse of the correlation time obtained per unit sampling time is sequentially displayed per unit sampling time.
Claim 6
Dependent Claim
22 words
An ophthalmological diagnosis method as set forth in claim 3, wherein the count data are grouped according to the calculated correlation time.
Claim 7
Dependent Claim
21 words
An ophthalmological diagnosis method as set forth in claim 1, wherein the count data are grouped according to the calculated variance.
Claim 8
Dependent Claim
24 words
An ophthalmological diagnosis method as set forth in claim 6, wherein the photon correlation function is obtained for each of the grouped count data.
Claim 9
Dependent Claim
29 words
An ophthalmological diagnosis method as set forth in the claim 1, wherein the variance calculated per unit sampling time is sequentially displayed per unit sampling time as time-series data.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-26 | 1995-11-25 | 1996-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-26 | 1999-11-25 | 2000-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-26 | 2003-11-25 | 2004-05-26 | $7700.00 | Window Closed / Lapsed |