US5115805A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ultrasound-enhanced delivery of materials into and through the skin
Assignee: Janssen Pharmaceuticals Inc
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Filing: 1990-02-23
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Granted: 1992-05-26
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Expires: 2010-02-23
Abstract
Abstract A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.
Inventors
- 👤 Durairaj Bommannan
- 👤 Hirohisa Okuyama
- 👤 Richard H. Guy
- 👤 Paul Stauffer
- 👤 Gordon L. Flynn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:41
CPC Classifications
A; A61; A61N; A61N7/00; A61N7/02; A61K; A61K9/00; A61K9/0002; A61K9/0009; A61M; A61M37/00; A61M37/0092; A61B; A61B10/00; A61B10/0045; A61B10/02; A61B17/00; A61B2017/00743; A61B2017/00747; A61B2017/00765; A61M2037/0007; A61N1/00; A61N1/18; A61N1/20; A61N1/30
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
74 words
A method for enhancing the rate of permeation of a drug medium into a selected intact area of an individual's body surface, which method comprises: (a) contacting the selected intact area with the drug medium; and (b) applying ultrasound having a frequency of above 10 MHz to said selected area for a treatment time in the range of about 30 seconds to 60 minutes at an intensity effective to enhance the rate of permeation.
Claim 2
Independent Claim
74 words
A method for enhancing the rate of permeation of a drug medium into a selected intact area of an individual's body surface, which method comprises: (a) contacting the selected intact area with the drug medium; and (b) applying ultrasound having a frequency of above 10 MHz to said selected area for a treatment time in the range of about 30 seconds to 60 minutes at an intensity effective to enhance the rate of permeation.
Claim 3
Dependent Claim
21 words
The method of claim 1, wherein said ultrasound has a frequency in the range of about 15 MHz to 50 MHz.
Claim 4
Dependent Claim
20 words
The method of claim 2, wherein said ultrasound has a frequency in the range of about 15 to 25 MHz.
Claim 5
Dependent Claim
19 words
The method of claim 1, wherein said treatment time is in the range of about 5 to 45 minutes.
Claim 6
Dependent Claim
19 words
The method of claim 4, wherein said treatment time is in the range of about 5 to 30 minutes.
Claim 7
Dependent Claim
15 words
The method of claim 5, wherein said treatment time is less than about 10 minutes.
Claim 8
Dependent Claim
19 words
The method of claim 1, wherein the intensity of said ultrasound is less than about 5.0 W/cm 2 .
Claim 9
Dependent Claim
23 words
The method of claim 7, wherein the intensity of said ultrasound is in the range of about 0.01 to 5.0 W/cm 2 .
Claim 10
Dependent Claim
23 words
The method of claim 8, wherein the intensity of said ultrasound is in the range of about 0.05 to 3.0 W/cm 2 .
Claim 11
Dependent Claim
24 words
The method of claim 1, wherein said selected intact area of skin is in the range of about 1 to 100 cm 2 .
Claim 12
Dependent Claim
24 words
The method of claim 10, wherein said selected intact area of skin is in the range of about 5 to 100 cm 2 .
Claim 13
Dependent Claim
24 words
The method of claim 11, wherein said selected intact area of skin is in the range of about 10 to 50 cm 2 .
Claim 14
Dependent Claim
29 words
The method of claim 1, wherein said drug medium comprises a drug and a coupling agent effective to transfer said ultrasound to said body surface from an ultrasound source.
Claim 15
Dependent Claim
15 words
The method of claim 13, wherein said coupling agent is a polymer or a gel.
Claim 16
Dependent Claim
21 words
The method of claim 13, wherein said coupling agent is selected from the group consisting of glycerin, water, and propylene glycol.
Claim 17
Dependent Claim
12 words
The method of claim 13, wherein said drug is a proteinaceous drug.
Claim 18
Dependent Claim
15 words
The method of claim 13, wherein the drug medium further comprises a chemical permeation enhancer.
Claim 19
Dependent Claim
15 words
The method of claim 1, wherein steps (a) and (b) are carried out approximately simultaneously.
Claim 20
Dependent Claim
15 words
The method of claim 1, wherein step (b) is carried out prior to step (a).
Claim 21
Dependent Claim
15 words
The method of claim 1, wherein step (a) is carried out prior to step (b).
Claim 22
Dependent Claim
11 words
The method of claim 1, wherein the ultrasound is applied continuously.
Claim 23
Dependent Claim
10 words
The method of claim 1, wherein the ultrasound is pulsed.
Claim 24
Independent Claim
82 words
A method for enhancing the rate of permeation of a drug medium through a biological membrane, comprising the steps of: (a) contacting the biological membrane with the drug medium; and (b) applying ultrasound to the drug medium and membrane, the ultrasound having a frequency of above 10 MHz and being applied for a treatment time in the range of about 30 seconds to 60 minutes at an intensity sufficient to enhance the rate of permeation of the drug medium through the membrane.
Claim 25
Independent Claim
82 words
A method for enhancing the rate of permeation of a drug medium through a biological membrane, comprising the steps of: (a) contacting the biological membrane with the drug medium; and (b) applying ultrasound to the drug medium and membrane, the ultrasound having a frequency of above 10 MHz and being applied for a treatment time in the range of about 30 seconds to 60 minutes at an intensity sufficient to enhance the rate of permeation of the drug medium through the membrane.
Claim 26
Dependent Claim
16 words
The method as claimed in claim 23, wherein the frequency is of at least 15 MHz.
Claim 27
Dependent Claim
21 words
The method of claim 23, wherein said ultrasound has a frequency in the range of about 15 MHz to 50 MHz.
Claim 28
Dependent Claim
20 words
The method of claim 25, wherein said ultrasound has a frequency in the range of about 15 to 25 MHz.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-26 | 1995-11-25 | 1996-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-26 | 1999-11-25 | 2000-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-26 | 2003-11-25 | 2004-05-26 | $7700.00 | Window Closed / Lapsed |