US5108989A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of predisposing mammals to accelerated tissue repair
Assignee: Genentech Inc
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Filing: 1990-04-04
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Granted: 1992-04-28
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Expires: 2010-04-04
Abstract
Abstract A method of predisposing a mammal to accelerated tissue repair is provided. This method comprises systemically administering to the mammal, prior to its exposure to tissue damage, an effective amount of TGF-β. Preferably, the TGF-β is administered no more than about 24 hours prior to exposure to tissue damage.
Inventors
- 👤 Edward P. Amento
- 👤 L. Steven Beck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 15:05
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495; A; A61; A61P; A61P17/00; A61P43/00; A61K; A61K38/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
41 words
A method of predisposing a mammal to accelerated tissue repair comprising systematically administering to the mammal, within a time range of from about 24 hours to greater than about 5 minutes prior to tissue damage exposure, an effective amount of TGF-β.
Claim 2
Independent Claim
41 words
A method of predisposing a mammal to accelerated tissue repair comprising systematically administering to the mammal, within a time range of from about 24 hours to greater than about 5 minutes prior to tissue damage exposure, an effective amount of TGF-β.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the administration is in a single dose.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein the administration is intravenous.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the TGF-β is human TGF-β.
Claim 6
Dependent Claim
10 words
The method of claim 4, wherein the TGF-β is TGF-β1.
Claim 7
Dependent Claim
10 words
The method of claim 1 wherein the mammal is human.
Claim 8
Dependent Claim
19 words
The method of claim 1 wherein the tissue repair is wound healing and the tissue damage is a wound.
Claim 9
Dependent Claim
25 words
The method of claim 1 wherein the tissue repair is bone repair and the tissue damage is a bone fracture, prosthetic implant, or bony defect.
Claim 10
Dependent Claim
12 words
The method of claim 1 wherein the tissue damage is surgical incision.
References Cited (Backward Citations)
EP0375127A1
Cited
WO1991000103A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-28 | 1995-10-28 | 1996-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-28 | 1999-10-28 | 2000-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-28 | 2003-10-28 | 2004-04-28 | $7700.00 | Window Closed / Lapsed |