US5093505A
Expired / Lapsed
US
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Novel heterocyclic compound, carcinostatic agent, and carcinoma controlling method
Assignee: Wakunaga Pharmaceutical Co Ltd
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Filing: 1990-05-25
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Granted: 1992-03-03
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Expires: 2010-05-25
Abstract
Abstract Heterocyclic compounds of the general formula: ##STR1## wherein R 11 is a hydroxyl group or a lower alkoxy group, R 12 is a lower alkoxy group, R 13 is a saturated or unsaturated hydrocarbon group, X is an oxygen atom or a sulfur atom, and Y is an oxygen atom or --NH-- which may have a lower alkyl substituent, or salts thereof are novel and effective in controlling carcinoma.
Inventors
- 👤 Hoyoku Nishino
- 👤 Yukihiro Kodera
- 👤 Toshihiko Sumida
- 👤 Susumu Yoshida
- 👤 Hiromichi Matsuura
- 👤 Yoichi Itakura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:43
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/69; A; A61; A61P; A61P35/00; C07D213/70; C07D309/00; C07D309/34; C07D309/36; C07D309/40
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
53 words
A heterocyclic compound of the general formula: ##STR6## wherein R 11 is a hydroxyl group or a lower alkoxy group, R 12 is a lower alkoxy group, R 13 is a lower alkyl group, X is an oxygen atom or a sulfur atom, and Y is an oxygen atom, or a salt thereof.
Claim 2
Dependent Claim
53 words
A heterocyclic compound of the general formula: ##STR6## wherein R 11 is a hydroxyl group or a lower alkoxy group, R 12 is a lower alkoxy group, R 13 is a lower alkyl group, X is an oxygen atom or a sulfur atom, and Y is an oxygen atom, or a salt thereof.
Claim 3
Dependent Claim
41 words
A carcinostatic composition, comprising an effective amount of a heterocyclic compound or a salt thereof as set forth in claim 1 as an active ingredient and a pharmaceutically acceptable carrier, wherein said effective amount is from 10 mg to 10 grams.
Claim 4
Dependent Claim
18 words
The heterocyclic compound of claim 1, which is selected from the group consisting of 3-hydroxy-6-methyl-5-methoxy-2-pentyl-4H-pyran-4-one, 6-methyl-3,5-dimethoxy-2-pentyl-4H-pyran-4-one, and 3-hydroxy-6-methyl-5-methoxy-2-pentyl-4H-pyran-4-thione.
Claim 5
Dependent Claim
21 words
The heterocyclic compound of claim 1, wherein R 13 is a saturated linear alkyl group having 1 to 6 carbon atoms.
Claim 6
Dependent Claim
13 words
The heterocyclic compound of claim 4, wherein R 13 is a methyl group.
Claim 7
Dependent Claim
25 words
The carcinostatic composition of claim 2, wherein said heterocyclic compound is selected from the group consisting of 3-hydroxy-6-methyl-5-methoxy-2-pentyl-4H-pyran-4-one, 6-methyl-3,5-dimethoxy-2-pentyl-4H-pyran-4H-pyran-4-one, and 3-hydroxy-6-methyl-5methoxy-2-pentyl-4H-pyran-4-thione, hydroxy-6-methyl-5-methoxy-2-pentyl-4-pyridone, hydroxy-1,6-dimethyl-5-methoxy-2-pentyl-4-pyridone, and hydroxy-1,6-dimethyl-5-methoxy-2-pentyl-4-pyridinethione.
References Cited (Backward Citations)
US4891361A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-03 | 2003-09-02 | 2004-03-03 | $7700.00 | Window Closed / Lapsed |