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US5087336A Expired / Lapsed US ⏱️ 0.0 years remaining

Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation

Assignee: Life Resonances Inc
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Filing: 1989-04-25
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Granted: 1992-02-11
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Expires: 2009-04-25
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Abstract

Abstract Methods and apparatus for regulating ion movement across biological membranes are provided. In one aspect, harmonic frequencies of a fluctuating magnetic field based on cyclotron resonance principles are provided for selectively enhancing transmembrane ion movement. In another aspect, a method and apparatus are provided for simultaneously regulating the transmembrane movement of multiple distinct ionic species using a fluctuating magnetic field. Therapeutic applications of harmonic tuning and multiple tuning are also provided.

Inventors

  • 👤 Abraham R. Liboff
  • 👤 Bruce R. McLeod
  • 👤 Stephen D. Smith

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 02:04
CPC Classifications
A; A61; A61N; A61N2/00; A61N2/02

Claims Analysis

Total Claims: 42
Claim 1
Independent Claim 178 words
An apparatus for regulating the movement of a preselected ion across a cell membrane, comprising: means for generating an applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of a preselected ion, said applied magnetic field resulting in a magnetic flux density in said space of a known average value parallel to said predetermined axis; means associated with said magnetic field generating means for fluctuating said magnetic flux density such that said known average value is a non-zero average value; means for creating a predetermined relationship between the frequency of said fluctuations and said non-zero average value of said magnetic flux density, wherein said predetermined relationship is determined using the equation f ch =XBq/2πm, where f ch is the frequency of the fluctuating magnetic flux density parallel to said predetermined axis in Tesla, q is the charge of said preselected ion in Coulombs, m is the mass of said preselected ion in kilograms, and X is a selected odd integer greater than 1.
Claim 2
Independent Claim 178 words
An apparatus for regulating the movement of a preselected ion across a cell membrane, comprising: means for generating an applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of a preselected ion, said applied magnetic field resulting in a magnetic flux density in said space of a known average value parallel to said predetermined axis; means associated with said magnetic field generating means for fluctuating said magnetic flux density such that said known average value is a non-zero average value; means for creating a predetermined relationship between the frequency of said fluctuations and said non-zero average value of said magnetic flux density, wherein said predetermined relationship is determined using the equation f ch =XBq/2πm, where f ch is the frequency of the fluctuating magnetic flux density parallel to said predetermined axis in Tesla, q is the charge of said preselected ion in Coulombs, m is the mass of said preselected ion in kilograms, and X is a selected odd integer greater than 1.
Claim 3
Dependent Claim 56 words
The apparatus recited in claim 1, wherein said space is subject to a local magnetic field having a component vector parallel to said predetermined axis and wherein said non-zero average value of said magnetic flux density is a net average value which includes the magnetic flux density of said component vector of said local magnetic field.
Claim 4
Dependent Claim 24 words
The apparatus recited in claim 1, wherein said selected odd integer is selected from the group consisting of odd integers from 1 to 19.
Claim 5
Dependent Claim 22 words
The apparatus recited in claim 1, wherein said means for creating said predetermined relationship includes a magnetic field sensor and a microprocessor.
Claim 6
Independent Claim 177 words
A method for regulating the movement of a preselected ion across a cell membrane, comprising: generating an applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of a preselected ion, said applied magnetic field resulting in a magnetic flux density in said space of a known average value parallel to said predetermined axis; fluctuating said magnetic flux density such that said known average value is a non-zero average value; creating a predetermined relationship between the frequency of said fluctuations and said non-zero average value of said magnetic flux density, wherein said predetermined relationship is determined using the equation f ch =XBq/2πm, where f ch is the frequency of the fluctuating magnetic flux density in Hertz, B is the non-zero average value of the flux density parallel to said predetermined axis in Tesla, q is the charge of said preselected ion in Coulombs, m is the mass of said preselected ion in kilograms, and X is a selected odd integer greater than 1.
Claim 7
Independent Claim 177 words
A method for regulating the movement of a preselected ion across a cell membrane, comprising: generating an applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of a preselected ion, said applied magnetic field resulting in a magnetic flux density in said space of a known average value parallel to said predetermined axis; fluctuating said magnetic flux density such that said known average value is a non-zero average value; creating a predetermined relationship between the frequency of said fluctuations and said non-zero average value of said magnetic flux density, wherein said predetermined relationship is determined using the equation f ch =XBq/2πm, where f ch is the frequency of the fluctuating magnetic flux density in Hertz, B is the non-zero average value of the flux density parallel to said predetermined axis in Tesla, q is the charge of said preselected ion in Coulombs, m is the mass of said preselected ion in kilograms, and X is a selected odd integer greater than 1.
Claim 8
Dependent Claim 54 words
The method recited in claim 5, wherein said space is subject to a local magnetic field having a component parallel to said predetermined axis and wherein said non-zero average value of said magnetic flux density is a net average value which includes the magnetic flux density of said component of said local magnetic field.
Claim 9
Dependent Claim 24 words
The method recited in claim 5, wherein said selected odd integer is selected from the group consisting of odd integers from 1 to 19.
Claim 10
Dependent Claim 23 words
The method recited in claim 5, wherein said at least one living cell is a region of living tissue of a biological subject.
Claim 11
Dependent Claim 25 words
The method recited in claim 8, wherein said region of living tissue is bone tissue and said biological subject is a human or animal subject.
Claim 12
Dependent Claim 16 words
The method recited in claim 9, wherein said predetermined relationship stimulates growth of said bone tissue.
Claim 13
Dependent Claim 30 words
The method recited in claim 9, wherein said bone tissue is afflicted with osteoporosis and wherein said method therapeutically treats said bone tissue by reducing the extent of said osteoporosis.
Claim 14
Dependent Claim 11 words
The method recited in claim 9, wherein said method prevents osteoporosis.
Claim 15
Dependent Claim 40 words
The method recited in claim 5, wherein said at least one living cell is substantially an entire human or animal subject afflicted with osteoporosis and wherein said method systemically therapeutically treats said subject by reducing the extent of said osteoporosis.
Claim 16
Dependent Claim 27 words
The method recited in claim 5, wherein said at least one living cell is substantially an entire human or animal subject and wherein said method prevents osteoporosis.
Claim 17
Dependent Claim 34 words
The method recited in claim 8, wherein said living tissue is non-osseous, non-cartilaginous connective tissue, said biological subject is human or animal, and said method stimulates the growth of said non-osseous, non-cartilaginous connective tissue.
Claim 18
Dependent Claim 30 words
The method recited in claim 8, wherein said living tissue is cartilaginous tissue, said biological subject is human or animal, and said method stimulates the growth of said cartilaginous tissue.
Claim 19
Independent Claim 224 words
An apparatus for simultaneously regulating the movement of at least two different ions across a cell membrane, comprising: means for generating an applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of at least two different preselected ions, said applied magnetic field resulting in a magnetic flux density in said space of a known average value parallel to said predetermined axis; means associated with said magnetic field generating means for fluctuating said magnetic flux density such that said know average value is a non-zero average value; means for determining a value f ch for each of said preselected ions, where f ch =XBq/2πm, B is said non-zero average value of said magnetic flux density along said axis, q is the charge of said ion in Coulombs, m is the mass of said ion in kilograms, and X is a selected positive non-zero odd integer; means for selecting a value f cs in Hertz from which each value f ch deviates less than a predetermined percentage; fluctuating said magnetic field parallel to said axis at a rate which is equal to said f cs value; and maintaining the ratio of said f cs rate of fluctuation to said non-zero average value of said magnetic flux density parallel to said axis.
Claim 20
Independent Claim 224 words
An apparatus for simultaneously regulating the movement of at least two different ions across a cell membrane, comprising: means for generating an applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of at least two different preselected ions, said applied magnetic field resulting in a magnetic flux density in said space of a known average value parallel to said predetermined axis; means associated with said magnetic field generating means for fluctuating said magnetic flux density such that said know average value is a non-zero average value; means for determining a value f ch for each of said preselected ions, where f ch =XBq/2πm, B is said non-zero average value of said magnetic flux density along said axis, q is the charge of said ion in Coulombs, m is the mass of said ion in kilograms, and X is a selected positive non-zero odd integer; means for selecting a value f cs in Hertz from which each value f ch deviates less than a predetermined percentage; fluctuating said magnetic field parallel to said axis at a rate which is equal to said f cs value; and maintaining the ratio of said f cs rate of fluctuation to said non-zero average value of said magnetic flux density parallel to said axis.
Claim 21
Dependent Claim 54 words
The apparatus recited in claim 17, wherein said space is subject to a local magnetic field having a component parallel to said predetermined axis and wherein said non-zero average value of said magnetic flux density is a net average value which includes the magnetic flux density of said component of said local magnetic field.
Claim 22
Dependent Claim 29 words
The apparatus recited in claim 17, wherein said selected odd integer is selected from the group consisting of 1, 3, 5, 7, 9, 11, 13, 15, 17, and 19.
Claim 23
Dependent Claim 17 words
The apparatus recited in claim 17, wherein said apparatus includes a magnetic field sensor and a microprocessor.
Claim 24
Independent Claim 215 words
A method for simultaneously regulating the movement of at least two different ions across a cell membrane, comprising the steps of: generating a fluctuating applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of at least two different preselected ions, said applied magnetic field resulting in a magnetic flux density in said space of a known non-zero average value parallel to said predetermined axis; fluctuating said magnetic flux density such that said known average value is a non-zero average value; determining a value f ch for each of said preselected ions where f ch =XBq/2πm, where B is said non-zero average value of said magnetic flux density along said axis, q is the charge of said ion in Coulombs, m is the mass of said ion in kilograms and X is a selected positive non-zero odd integer; selecting a value f cs in Hertz from which each value f ch deviates less than a predetermined percentage; fluctuating said magnetic field parallel to said axis at a rate which is equal to said f cs value; and maintaining the ratio of said f cs rate of fluctuation to said non-zero average value of said magnetic flux density parallel to said axis.
Claim 25
Independent Claim 215 words
A method for simultaneously regulating the movement of at least two different ions across a cell membrane, comprising the steps of: generating a fluctuating applied magnetic field parallel to a predetermined axis projecting through a space in which at least one living cell is positioned in the presence of at least two different preselected ions, said applied magnetic field resulting in a magnetic flux density in said space of a known non-zero average value parallel to said predetermined axis; fluctuating said magnetic flux density such that said known average value is a non-zero average value; determining a value f ch for each of said preselected ions where f ch =XBq/2πm, where B is said non-zero average value of said magnetic flux density along said axis, q is the charge of said ion in Coulombs, m is the mass of said ion in kilograms and X is a selected positive non-zero odd integer; selecting a value f cs in Hertz from which each value f ch deviates less than a predetermined percentage; fluctuating said magnetic field parallel to said axis at a rate which is equal to said f cs value; and maintaining the ratio of said f cs rate of fluctuation to said non-zero average value of said magnetic flux density parallel to said axis.
Claim 26
Dependent Claim 15 words
The method recited in claim 21, wherein said predetermined percentage is less than 5 percent.
Claim 27
Dependent Claim 17 words
The invention recited in claim 21, wherein said at least two different preselected ions comprises three ions.
Claim 28
Dependent Claim 29 words
The method recited in claim 21, wherein said selected odd integer is selected form the group consisting of 1, 3, 5, 7, 9, 11, 13, 15, 17 and 19.
Claim 29
Dependent Claim 23 words
The method recited in claim 21, wherein said at least one living cell is a region of living tissue of a biological subject.
Claim 30
Dependent Claim 67 words
The method recited in claim 25, wherein said region of living tissue is bone tissue, said biological subject is a human or animal subject, said at least 2 preselected ions are Ca ++ and Mg ++ , said value of X is 5 for said f ch value of Ca ++ and said value of X is 3 for said f ch value of Mg ++ .
Claim 31
Dependent Claim 25 words
The method recited in claim 26, wherein said value of f cs is about 75 Hertz and said method stimulates growth of said bone tissue.
Claim 32
Dependent Claim 30 words
The method recited in claim 26, wherein said bone tissue is afflicted with osteoporosis and wherein said method therapeutically treats said bone tissue by reducing the extent of said osteoporosis.
Claim 33
Dependent Claim 11 words
The method recited in claim 26, wherein said method prevents osteoporosis.
Claim 34
Dependent Claim 37 words
The method recited in claim 21, wherein said at least one living cell is substantially an entire human or animal subject afflicted with osteoporosis and wherein said method systemically therapeutically treats said subject by reducing said osteoporosis.
Claim 35
Dependent Claim 27 words
The method recited in claim 21, wherein said at least one living cell is substantially an entire human or normal subject and wherein said method prevents osteoporosis.
Claim 36
Dependent Claim 34 words
The method recited in claim 25, wherein said living tissue is non-osseous, non-cartilaginous connective tissue, said biological subject is human or animal, and said method stimulates the growth of said non-osseous, non-cartilaginous connective tissue.
Claim 37
Dependent Claim 30 words
The method recited in claim 25, wherein said living tissue is cartilaginous tissue, said biological subject is human or animal, and said method stimulates the growth of said cartilaginous tissue.
Claim 38
Independent Claim 95 words
A method of regulating transmembrane ion movement of preselected ionic species comprising of steps of exposing at least one living cell to a fluctuating magnetic flux density in the presence of said ionic species and controlling the rate of said fluctuations such that f c =Bq/2πm, where f c is the frequency of the fluctuating magnetic flux density in hertz, B is a non-zero average value of the flux density in Tesla, q is the charge of said preselected ionic species in Coulombs and m is the mass of said preselected ionic species in kilograms.
Claim 39
Independent Claim 95 words
A method of regulating transmembrane ion movement of preselected ionic species comprising of steps of exposing at least one living cell to a fluctuating magnetic flux density in the presence of said ionic species and controlling the rate of said fluctuations such that f c =Bq/2πm, where f c is the frequency of the fluctuating magnetic flux density in hertz, B is a non-zero average value of the flux density in Tesla, q is the charge of said preselected ionic species in Coulombs and m is the mass of said preselected ionic species in kilograms.
Claim 40
Dependent Claim 25 words
The method recited in claim 34, wherein said magnetic flux density is fluctuated at a value determined by multiplying f c by an odd integer.
Claim 41
Independent Claim 125 words
A method of simultaneously regulating the transmembrane movement of at least two preselected ions in a biological system, said method comprising the steps of identifying the charge-to-mass ratios of said at least two preselected ions, determining a value f cs for said at least two preselected ions, said f cs value being based on the cyclotron resonance frequencies of said at least two preselected ions using said charge-to-mass ratios, exposing a biological system which includes said at least two preselected ions and a biological membrane to a fluctuating magnetic field having a non-zero average flux density and a fluctuating magnetic field at a frequency substantially equal to said fcs value, thereby causing transmembrane movement of said at least two preselected ions across said biological membrane.
Claim 42
Independent Claim 125 words
A method of simultaneously regulating the transmembrane movement of at least two preselected ions in a biological system, said method comprising the steps of identifying the charge-to-mass ratios of said at least two preselected ions, determining a value f cs for said at least two preselected ions, said f cs value being based on the cyclotron resonance frequencies of said at least two preselected ions using said charge-to-mass ratios, exposing a biological system which includes said at least two preselected ions and a biological membrane to a fluctuating magnetic field having a non-zero average flux density and a fluctuating magnetic field at a frequency substantially equal to said fcs value, thereby causing transmembrane movement of said at least two preselected ions across said biological membrane.

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