US5081295A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Activated polyers and conjugates thereof
Assignee: Xoma Royalty Corp
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Filing: 1990-08-24
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Granted: 1992-01-14
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Expires: 2010-08-24
Abstract
Abstract Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R 1 is H, C 1 -C 20 alkyl, phenyl, (C 1 -C 10 alkyl)-substituted phenyl, or phenyl-substituted C 1 -C 10 alkyl; R 2 is C 2 -C 5 alkylene or (C 1 -C 4 alkoxy)-substituted C 2 -C 5 alkylene; R 3 is ##STR2## R 4 is H or C 1 -C 4 alkyl; n is at least 5; and m is zero or 1.
Inventors
- 👤 Dayton T. Reardan
- 👤 Dane A. Goff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:24
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/333; C08G65/33379; C08G65/33386; C08G65/33389; C07; C07C; C07C229/00; C07C229/52; C07C229/54; C07C229/60; C07C237/00; C07C237/28; C07C237/32; C07C271/00; C07C271/06; C07C271/08; C07C271/26; C07C271/28; C08G65/321; C08G65/322; C08G65/338
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
121 words
A compound having the formula ##STR7## in which R 1 is a member selected from the group consisting of H, C 1 -C 20 alkyl, phenyl, (C 1 -C 10 alkyl)-substituted phenyl, or phenyl-substituted C 1 -C 10 alkyl; R 2 is a member selected from the group consisting of C 2 -C 5 alkylene and C 1 -C 4 alkoxy-substituted C 2 -C 5 alkylene; R 3 is a member selected from the group consisting of ##STR8## R 4 is a member selected from the group consisting of H and C 1 -C 4 alkyl; n is at least 5; and the amino group occupies either a meta- or a para-position with respect to R 3 on the phenyl ring.
Claim 2
Dependent Claim
121 words
A compound having the formula ##STR7## in which R 1 is a member selected from the group consisting of H, C 1 -C 20 alkyl, phenyl, (C 1 -C 10 alkyl)-substituted phenyl, or phenyl-substituted C 1 -C 10 alkyl; R 2 is a member selected from the group consisting of C 2 -C 5 alkylene and C 1 -C 4 alkoxy-substituted C 2 -C 5 alkylene; R 3 is a member selected from the group consisting of ##STR8## R 4 is a member selected from the group consisting of H and C 1 -C 4 alkyl; n is at least 5; and the amino group occupies either a meta- or a para-position with respect to R 3 on the phenyl ring.
Claim 3
Dependent Claim
27 words
A compound in accordance with claim 1 in which R 1 is a member selected from the group consisting of H and C 1 -C 10 alkyl.
Claim 4
Dependent Claim
27 words
A compound in accordance with claim 1 in which R 1 is a member selected from the group consisting of H and C 1 -C 5 alkyl.
Claim 5
Dependent Claim
13 words
A compound in accordance with claim 1 in which R 1 is methyl.
Claim 6
Dependent Claim
17 words
A compound in accordance with claim 1 in which R 2 is C 2 -C 5 alkylene.
Claim 7
Dependent Claim
31 words
A compound in accordance with claim 1 in which R 2 is a member selected from the group consisting of --CH 2 --CH 2 -- and --CH(CH) 3 --CH 2 --.
Claim 8
Dependent Claim
17 words
A compound in accordance with claim 1 in which R 2 is --CH 2 --CH 2 --.
Claim 9
Dependent Claim
23 words
A compound in accordance with claim 1 in which R 4 is a member selected from the group consisting of H and methyl.
Claim 10
Dependent Claim
13 words
A compound in accordance with claim 1 in which R 4 is H.
Claim 11
Dependent Claim
14 words
A compound in accordance with claim 1 in which n is 10 to 1000.
Claim 12
Dependent Claim
14 words
A compound in accordance with claim 1 in which n is 50 to 200.
References Cited (Backward Citations)
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