US5077524A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gradient enhanced NMR correlation spectroscopy
Assignee: General Electric Co
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Filing: 1990-06-07
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Granted: 1991-12-31
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Expires: 2010-06-07
Abstract
Abstract A method for obtaining high resolution NMR spectra without the need for phase cycling includes the application of magnetic field gradient pulses to select specific coherences. By using actively shielded gradients, a gradient pulse is applied during the evolution period of the selected coherence to dephase the transverse magnetization and another gradient pulse refocuses the desired coherences remaining during the acquisition period.
Inventors
- 👤 Ralph E. Hurd
- 👤 Michael G. Boucher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:53
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/4828; G01R33/28; G01R33/42; G01R33/421; G01R33/483; G01R33/4833
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
232 words
A method for producing an NMR spectrum of a substance located in a region of interest, the steps comprising: applying a polarizing magnetic field to the substance; applying a first RF excitation field pulse to the substance to produce transverse magnetization; applying a first magnetic field gradient pulse to the substance during an evolution period following the application of the first RF excitation field pulse to prepare to select coherences by dephasing the transverse magnetization by a selected amount; actively shielding the region surrounding the region of interest to prevent eddy currents from being produced in the surrounding structures by the first magnetic field gradient pulse by producing a magnetic filed which substantially cancels the first magnetic field gradient outside the region of interest; applying a second RF excitation field pulse to the substance at the completion of the evolution period; applying a second magnetic field gradient pulse to the substance after the second RF excitation field pulse to refocus desired coherences that are dephased by the first magnetic field gradient pulse; actively shielding the region surrounding the region of interest to prevent eddy currents from being produced in the surrounding structures by the second magnetic field gradient pulse by producing a magnetic filed which substantially cancels the second magnetic field gradient outside the region of interest; and acquiring the NMR signal produced by the refocused transverse magnetization with a receiver coil.
Claim 2
Independent Claim
232 words
A method for producing an NMR spectrum of a substance located in a region of interest, the steps comprising: applying a polarizing magnetic field to the substance; applying a first RF excitation field pulse to the substance to produce transverse magnetization; applying a first magnetic field gradient pulse to the substance during an evolution period following the application of the first RF excitation field pulse to prepare to select coherences by dephasing the transverse magnetization by a selected amount; actively shielding the region surrounding the region of interest to prevent eddy currents from being produced in the surrounding structures by the first magnetic field gradient pulse by producing a magnetic filed which substantially cancels the first magnetic field gradient outside the region of interest; applying a second RF excitation field pulse to the substance at the completion of the evolution period; applying a second magnetic field gradient pulse to the substance after the second RF excitation field pulse to refocus desired coherences that are dephased by the first magnetic field gradient pulse; actively shielding the region surrounding the region of interest to prevent eddy currents from being produced in the surrounding structures by the second magnetic field gradient pulse by producing a magnetic filed which substantially cancels the second magnetic field gradient outside the region of interest; and acquiring the NMR signal produced by the refocused transverse magnetization with a receiver coil.
Claim 3
Dependent Claim
118 words
The method as recited in claim 1 which includes the further steps of: applying a third RF excitation field pulse to the subject to establish a second evolution period; applying a third magnetic field gradient pulse to the substance during the second evolution period to prepare to select desired coherences by dephasing the transverse magnetization by a second selected amount; actively shielding the region surrounding the region of interest to prevent eddy currents from being produced in the surrounding structures by the third magnetic field gradient pulse; and wherein the magnitude of the second magnetic filed gradient pulse is set to refocus the transverse magnetization that is dephased by both the first and third magnetic field gradient pulses.
Claim 4
Dependent Claim
58 words
The method as recited in claim 1 in which coherence of the order N is selected by the application of the first magnetic field gradient pulse and the subsequent second RF excitation field pulse, and the magnitude of the second magnetic field gradient pulse is N times larger than the magnitude of the first magnetic field gradient pulse.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-30 | 1995-07-01 | 1995-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-30 | 1999-07-01 | 1999-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-30 | 2003-07-01 | 2003-12-31 | $7700.00 | Window Closed / Lapsed |