US5071706A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oily, free-flowing, microcapsules
Assignee: Adare Pharma Solutions Inc
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Filing: 1989-08-31
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Granted: 1991-12-10
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Expires: 2009-08-31
Abstract
Abstract This disclosure is directed to the preparation of oily microcapsules which can be easily tray dried to a free flowing product without requiring special drying equipment. These microcapsules have a cell wall material having a first cell wall of gelatin/carboxymethylcellulose (CMC) which is prehardened (cross-linked) with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldehyde to which there is grafted formaldehyde and urea. The predominant portion, viz., approximately 95% by wt. of these microcapsules have a particle size less than 1500 microns and more characteristically have a particle size ranging from about 100 to about 400 microns (microcapsular diameter). These microcapsules contain less than approximately 3 wt. % free oil and more characteristically less than about 1 wt. % free oil (non-microencapsulated oil) and have less free (unreacted) formaldehyde, which can be extracted with water, than do prior art microencapsulated oily materials. The microcapsules of this invention are granular and free-flowing when dried.
Inventors
- 👤 Jon C. Soper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:08
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/11; A61K8/18; A61K8/72; A61K8/73; A61K8/731; A61K8/92; A61K8/922; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61Q; A61Q13/00; A61Q19/00; B; B01; B01J; B01J13/00; B01J13/02; B01J13/20; B01J13/206; A61K2800/00; A61K2800/40; A61K2800/41; A61K2800/412; A61Q15/00; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
92 words
Microencapsulated product having a predominant portion of individual microcapsules having a particle size less than about 1500 microns and containing oil core material, said microencapsulated product being free-flowing, having a free oil concentration less than about 3 wt. %, and being further characterized as substantially free of clumps and agglomerates of individual microcapsules and containing microcapsular cell wall material of gelatin/carboxymethylcellulose prehardened with a material selected from the, group consisting of formaldehyde, glyoxal and glutaraldehyde treated with polyvinyl alcohol and having grafted thereto formaldehyde and resorcinol and crosslinked with formaldehyde and urea.
Claim 2
Dependent Claim
92 words
Microencapsulated product having a predominant portion of individual microcapsules having a particle size less than about 1500 microns and containing oil core material, said microencapsulated product being free-flowing, having a free oil concentration less than about 3 wt. %, and being further characterized as substantially free of clumps and agglomerates of individual microcapsules and containing microcapsular cell wall material of gelatin/carboxymethylcellulose prehardened with a material selected from the, group consisting of formaldehyde, glyoxal and glutaraldehyde treated with polyvinyl alcohol and having grafted thereto formaldehyde and resorcinol and crosslinked with formaldehyde and urea.
Claim 3
Dependent Claim
13 words
Microencapsulated product as in claim 1 wherein said oil core material contains emollient.
Claim 4
Dependent Claim
13 words
Microencapsulated product as in claim 1 wherein said oil core material contains lubricant.
Claim 5
Dependent Claim
14 words
Microencapsulated product as in claim 1 wherein said oil core material contains mineral oil.
Claim 6
Dependent Claim
20 words
Microencapsulated product as in claim 1 wherein said microcapsule particle size ranges from about 100 microns to about 400 microns.
Claim 7
Dependent Claim
82 words
Microencapsulated product having a predominant portion of individual microcapsules having a particle size less than about 1500 microns and containing fragrance oil core material, said microencapsulated product being free-flowing and being further characterized as substantially free of clumps and agglomerates of individual microcapsules and containing microcapsular cell wall material of gelatin/carboxymethylcellulose prehardened with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldehyde treated with polyvinyl alcohol and having grafted thereto formaldehyde and resorcinol and crosslinked with formaldehyde and urea.
Claim 8
Dependent Claim
82 words
Microencapsulated product having a predominant portion of individual microcapsules having a particle size less than about 1500 microns and containing fragrance oil core material, said microencapsulated product being free-flowing and being further characterized as substantially free of clumps and agglomerates of individual microcapsules and containing microcapsular cell wall material of gelatin/carboxymethylcellulose prehardened with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldehyde treated with polyvinyl alcohol and having grafted thereto formaldehyde and resorcinol and crosslinked with formaldehyde and urea.
Claim 9
Dependent Claim
15 words
Microencapsulated product as in claim 6 wherein said fragrance oil contains citrus base fragrance oil.
Claim 10
Dependent Claim
19 words
Microencapsulated product as in claim 1 wherein said microcapsules have a particle size peak distribution of about 150 microns.
Claim 11
Dependent Claim
66 words
A process of producing the microencapsulated product of claim 1 which comprises microencapsulating an oil core material with a microcapsule cell wall system of gelatin/carboxymethylcellulose, prehardening same with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldehyde and thereafter treating with polyvinyl alcohol and grafting to the initially formed microcapsule cell wall material formaldehyde and resorcinol and subsequently crosslinking with formaldehyde and urea.
Claim 12
Dependent Claim
64 words
A process of producing the microencapsulated product of claim 6 which comprises microencapsulating an oily core material containing fragrance oil with a microcapsule cell wall system of gelatin/carboxymethylcellulose, prehardening same with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldehyde and thereafter grafting to the initially formed microcapsule cell wall material formaldehyde and resorcinol and subsequently crosslinking with formaldehyde and urea.
Claim 13
Dependent Claim
88 words
Aqueous formulations containing from about 10 to about 40 wt. % of individual microcapsules, having a particle size ranging from about 100 to about 400 microns and being substantially free of clumps and agglomerates of individual microcapsules, containing oil core material and containing microcapsular cell wall material of gelatin/carboxymethylcellulose prehardened with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldhyde treated with polyvinyl alcohol and having grafted thereto formaldehyde and resorcinol and crosslinked with formaldehyde and urea, with the remainder being water and formulation aids.
Claim 14
Dependent Claim
88 words
Aqueous formulations containing from about 10 to about 40 wt. % of individual microcapsules, having a particle size ranging from about 100 to about 400 microns and being substantially free of clumps and agglomerates of individual microcapsules, containing oil core material and containing microcapsular cell wall material of gelatin/carboxymethylcellulose prehardened with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldhyde treated with polyvinyl alcohol and having grafted thereto formaldehyde and resorcinol and crosslinked with formaldehyde and urea, with the remainder being water and formulation aids.
Claim 15
Dependent Claim
14 words
Aqueous formulations as in claim 11 wherein said oil core material contains fragrance oil.
Claim 16
Dependent Claim
15 words
Aqueous formulations as in claim 11 wherein said oil core material contains color producing material.
Claim 17
Dependent Claim
13 words
Aqueous formulations as in claim 11 wherein said oil core material contains lubricant.
Claim 18
Dependent Claim
16 words
Aqueous formulations as in claim 11 wherein said oil core material contains citrus base fragrance oil.
Claim 19
Dependent Claim
14 words
Aqueous formulations as in claim 11 wherein said oil core material contains an emollient.
Claim 20
Dependent Claim
19 words
Aqueous formulations as in claim 11 wherein said microcapsules have a particle size peak distribution of about 150 microns.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-09 | 1995-06-10 | 1995-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-09 | 1999-06-10 | 1999-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-09 | 2003-06-10 | 2003-12-10 | $7700.00 | Window Closed / Lapsed |