Method of and apparatus for electrically stimulating quadriceps muscles of an upper motor unit paraplegic

Claim 2

Self adjusting apparatus for the electrical stimulation of neural motor units (NMU's) of the sets of quadriceps muscles of an upper motor neuron paraplegic, said apparatus having a first channel comprising: (a) a controllable stimulation generator for generating an electrical stimulation (ES) signal in the form of a train of pulses; (b) ES electrode means connected to the output of said stimulation generator for applying said ES signal to the MNU's of one set of quadriceps muscles thereby stimulating the same; (c) EMG electrode means adapted to be connected to the stimulated muscles for picking up myoelectric (EMG) signals produced thereby in response to the ES signal; and (d) control means responsive to said EMG signals for controlling said stimulation generator by controlling one or more of the following ES parameters of said ES signal: pulse repetition rate, amplitude, and pulse width of the train of pulse produced by said stimulation generator.

Claim 3

Self adjusting apparatus according to claim 1 wherein one electrode means constitutes both said ES electrode means and the EMG electrode means.

Claim 4

Self adjusting apparatus according to claim 2 wherein said control means comprises: (a) means for separating EMG signals from said ES signals and producing a separated EMG signal; (b) means for processing a separated EMG signal to produce an EMG parameter representative thereof; (c) comparator means responsive to EMG parameters produced at different times for producing a control signal when a later EMG parameter has a value less than a predetermined percentage of an earlier EMG parameter; and (d) ES parameter means responsive to said control signal for establishing said ES parameters.

Claim 5

Self adjusting apparatus according to claim 3 wherein said means for separating includes: (a) blocking means connected to said same electrode means and responsive to the applied ES signal and the pickoff EMG signal for blocking portions of said ES signal and producing blocked signals; and (b) filter means responsive to said blocked signals for filtering remaining portions of said ES signal and producing said separated EMG signal.

Claim 6

Self adjusting apparatus according to claim 4 wherein said blocking means clips the applied signals at a predetermined level whereby said blocked signal consists of only of signals of less than said predetermined level.

Claim 7

Self adjusting apparatus according to claim 5 wherein said filter means is low pass filter for producing said separated EMG signal by eliminating remnants of said ES signal in said blocked signal.

Claim 8

Self adjusting apparatus according to claim 3 wherein said means for processing includes detector means for detecting peaks in said separated EMG signal which occur within a time frame lying between successive pulses of said ES signal, each peak of a separated EMG signal being the EMG parameter representative thereof; and storage means for storing a reference representative of peaks produced during initial application of said ES signal to said muscle; and said comparator means is constructed and arranged to compare a current peak in said separated EMG signal with said reference.

Claim 9

Self adjusting apparatus according to claim 7 wherein said ES parameter means comprises a pulse rate modulator circuit for controlling the pulse repetition rate of said stimulation generator, said last mentioned modulation circuit being constructed and arranged to increase the pulse repetition rate by a predetermined amount in response to a control signal from said comparator means.

Claim 10

Self adjusting apparatus according to claim 8 wherein said means for processing includes frame control means responsive to the output of said pulse rate modulator circuit for establishing the limits of said time frames.

Claim 11

Self adjusting apparatus according to claim 3 wherein said ES parameter means comprises a pulse amplitude modulator circuit for controlling the amplitude of the pulses produced by said stimulation generator, said last mentioned modulator circuit being constructed and arranged to increase the amplitude of said ES signal by a predetermined amount in response to a control signal from said comparator means.

Claim 12

Self adjusting apparatus according to claim 3 wherein said ES parameter means comprises a pulse width modulator circuit for controlling the pulse width of the pulses produces by said stimulator generator, said last mentioned modulator circuit being constructed and arranged to increase the pulse width by a predetermined amount in response to a control signal from said comparator means.

Claim 13

Self adjusting apparatus according to claim 3 wherein said ES parameter means comprises: (a) a pulse rate modulator circuit for controlling the pulse repetition rate of said stimulation generator, said last mentioned modulator circuit being constructed and arranged to increase the pulse repetition rate by a predetermined amount in response to a control signal from the comparator means; (b) a pulse amplitude modulator circuit for controlling the amplitude of the pulses produced by said stimulation generator, said last mentioned modulator circuit being constructed and arranged to increase the amplitude of the pulses produced by said stimulation circuit by a predetermined amount in response to a control signal from said comparator means; and (c) a pulse width modulator circuit for controlling the pulse width of the pulses produced by said stimulation generator, said last mentioned modulator circuit being constructed and arranged to increase the pulse width by a predetermined amount in response to a control signal from said comparator means.

Claim 14

Self adjusting apparatus according to claim 8 including a pulse rate monitor for monitoring the pulse repetition rate of a second channel whose ES electrode means are applied to the NMU's of the other set of quadriceps muscles of said paraplegic, said monitor being constructed and arranged to cause said ES parameter control means to change the pulse repetition rate of said first channel complimentary to changes in the pulse repetition rate of said second channel.

Claim 15

Self adjusting apparatus according to claim 8 including a pulse width modulator for controlling the pulse width of the pulses of the ES signal, said pulse width modulator being constructed and arranged to increase the pulse width during initial stimulation, and to decrease the pulse width during termination of stimulation for effecting smooth contraction/relaxation of the muscle being stimulated.

Claim 16

Self adjusting apparatus according to claim 14 wherein said stimulation generator is constructed and arranged to produce monopolar pulses.

Claim 17

Self adjusting apparatus according to claim 1 wherein said stimulation generators is constructed and arranged to produce pairs of bipolar pulses.

Claim 18

Self adjusting apparatus according to claim 16 wherein the pulses of a pair have a width of 50-200 microseconds, and are separated by less than about 50 microseconds, and the pulse repetition rate is about 25 pulses per second.

Claim 19

Self adjusting apparatus according to claim 17 wherein a sequence of bipolar pulses is a positive pulse followed by a negative pulse.

Claim 20

Self adjusting apparatus according to claim 17 wherein a sequence of bipolar pulses is a negative pulse followed by a positive pulse.

Claim 21

Self adjusting apparatus according to claim 1 including a second channel like said first channel for electrically stimulating the NMU's of the other set of quadriceps muscles of said paraplegic, the maximum pulse repetition rate of the ES signal being about 25 pulses per second, and the minimum being much less than 25 pulse per second, the rate alternating between the channels in complimentary fashion.

Claim 22

Self adjusting apparatus according to claim 7 including switch means for selectively resetting said storage means and effecting storage of a new reference during a stimulation session.

Claim 23

Self adjusting apparatus according to claim 3 wherein said means for processing detects and stores successive peaks of said separated EMG signals which occur within a time frame lying between successive pulses of said ES signal, and also stores the time between said successive peaks, the amplitudes of said successive peaks, and said time periods therebetween being the EMG parameters representative of a separated EMG signal.

Claim 26

A method according to claim 23 wherein one or more of the following ES parameters of the ES signal is modulated: the pulse repetition rate, the amplitude, and the pulse width of the train of pulses that constitute the ES signal.

Claim 27

A method according to claim 24 wherein an ES signal is also applied to the other set of quadriceps muscles, and wherein the pulse repetition rate of the ES signal is modulated such that while the patient is standing, and while both sets of quadriceps muscles are stimulated to produce leg and/or knee extensions for standing, the pulse repetition rate applied to one set of quadriceps muscles is well below 25 pulses per second, whereas at the same time the pulse repetition rate applied to the other set of quadriceps muscles is about 25 pulses per second.

Claim 28

A method according to claim 24 wherein the pulse repetition rate of the ES signal is modulated by detecting peaks in the EMG signal within a time frame defined by successive pulses of said ES signal, storing a reference representative of peaks produced during initial application of said ES signal to said muscle, and comparing a current peak in said EMG signal with said reference for the purpose of determining when the current peak falls below a threshold indicative of the onset of muscle fatigue.

Claim 29

A method according to claim 23 wherein the EMG parameter includes one or more of the following: successive peaks in the EMG signal within the period between successive pulses of said ES signal, and time periods between such successive peaks; and said method includes storing the EMG parameters that results from initial stimulation to define a standard parameter, and comparing later occurring EMG parameters with the standard parameter, and modulating the ES signal in accordance with the results of the comparison step.

Claim 30

A method according to claim 25 wherein the pulse repetition rate of signals applied to each set of quadriceps muscles are simultaneously changed when muscle fatigue is detected.

Claim 31

A method according to claim 25 wherein changes in the pulse repetition rate of signals applied to each set of quadriceps muscles are simultaneously changed.