US5068419A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Separation of an organic acid from a fermentation broth with an anionic polymeric adsorbent
Assignee: Honeywell UOP LLC
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Filing: 1989-05-08
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Granted: 1991-11-26
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Expires: 2009-05-08
Abstract
Abstract An organic acid is separated from a fermentation broth by using an adsorbent comprising a water-insoluble macroreticular or gel weakly basic anionic exchange resin possessing tertiary amine or pyridine functional groups or a strongly basic anionic exchange resin possessing quaternary amine functional groups. The resins are in sulfate form and have a cross-linked acrylic or styrene resin matrix. The organic acid is desorbed with water or dilute inorganic acid, e.g., sulfuric. The pH of the feed is maintained below the first ionization constant (pKa 1 ) of the organic acid to obtain high selectivity.
Inventors
- 👤 Santi Kulprathipanja
- 👤 Anil R. Oroskar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:22
CPC Classifications
C; C07; C07C; C07C51/00; C07C51/42; C07C51/47
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
114 words
A process for separating a mono-, di- or polycarboxylic acid from a fermentation broth feed mixture containing said carboxylic acid produced by a fermentation process comprising contacting said feed mixture with an anionic polymeric adsorbent selected from the group consisting of a weakly basic anionic exchange resin possessing tertiary amine or pyridine functional groups and a strongly basic anionic exchange resin possessing quaternary amine functional groups and mixtures thereof at adsorption conditions selected to selectively adsorb said carboxylic acid and thereafter recovering said carboxylic acid from said adsorbent with a desorbent at desorption conditions, said adsorption conditions being characterized as a pH below the first ionization constant (pKa 1 ) of said carboxylic acid.
Claim 2
Dependent Claim
114 words
A process for separating a mono-, di- or polycarboxylic acid from a fermentation broth feed mixture containing said carboxylic acid produced by a fermentation process comprising contacting said feed mixture with an anionic polymeric adsorbent selected from the group consisting of a weakly basic anionic exchange resin possessing tertiary amine or pyridine functional groups and a strongly basic anionic exchange resin possessing quaternary amine functional groups and mixtures thereof at adsorption conditions selected to selectively adsorb said carboxylic acid and thereafter recovering said carboxylic acid from said adsorbent with a desorbent at desorption conditions, said adsorption conditions being characterized as a pH below the first ionization constant (pKa 1 ) of said carboxylic acid.
Claim 3
Dependent Claim
46 words
The process of claim 1 further characterized in that said adsorption and desorption conditions include a temperature within the range of from about 20° C. to about 200° C. and a pressure within the range of from about atmospheric to about 500 psig (3450 kPa gauge).
Claim 4
Dependent Claim
24 words
The process of claim 1 further characterized in that said desorption is effected in the liquid phase with water or a dilute inorganic acid.
Claim 5
Dependent Claim
20 words
The process of claim 1 further characterized in that said desorbent is 0.002 to 1.0N H 2 SO 4 .
Claim 6
Dependent Claim
26 words
The process of claim 1 further characterized in that the pH of said feed mixture is lower than the ionization constant (pKa) of said carboxylic acid.
Claim 7
Dependent Claim
26 words
The process of claim 1 further characterized in that said adsorbent comprises a tertiary amine functional group supported on a matrix comprising a crosslinked acrylic resin.
Claim 8
Dependent Claim
32 words
The process of claim 1 further characterized in that said adsorbent comprises a pyridine functional group supported on a matrix selected from the group consisting of polystyrene resins and crosslinked acrylic resins.
Claim 9
Dependent Claim
26 words
The process of claim 1 further characterized in that said adsorbent comprises a quaternary ammonium functional group supported on a matrix comprising a crosslinked acrylic resin.
Claim 10
Dependent Claim
13 words
The process of claim 1 wherein said adsorbent is in the sulfate form.
Claim 11
Dependent Claim
32 words
The process of claim 1 further characterized in that said feed mixture comprises at least one additional material selected from the group consisting of salts, acetic acid, carbohydrates, amino acids and proteins.
Claim 12
Dependent Claim
12 words
The process of claim 1 wherein said carboxylic acid is tartaric acid.
Claim 13
Dependent Claim
18 words
The process of claim 1 wherein the process is performed in a continuous, countercurrent simulated moving bed system.
Claim 14
Dependent Claim
27 words
The process of claim 1 wherein said carboxylic acid is selected from the group consisting of citric acid, lactic acid, aconitic acid, glutamic acid and tartaric acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-11-25 | 1995-05-27 | 1995-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-11-25 | 1999-05-27 | 1999-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-11-25 | 2003-05-27 | 2003-11-26 | $7700.00 | Window Closed / Lapsed |