US5067093A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reference reading in an analyzer
Assignee: Clinical Diagnostic Systems Inc
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Filing: 1990-01-24
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Granted: 1991-11-19
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Expires: 2010-01-24
Abstract
Abstract A method and apparatus are disclosed for reading a test element and a reference element in an incubator to insure that a) they are both read at the same wavelength and b) the reading at this wavelength of the reference element used to compare the test element reading, is the closest in point of time to the reading taken of the test element. In some cases, this requires the comparison with a reference element that is read after the reading of the test element.
Inventors
- 👤 Catherine S. Przybylowicz
- 👤 Edwin W. Brill, Jr.
- 👤 Luigi A. Carrozziere
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:37
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/84; G01N21/8483; G01N21/17; G01N21/47; G01N21/4738; G01N2021/4776; G01N2021/478; G01N2201/00; G01N2201/12; G01N2201/127; G01N2201/12746; G01N2201/12753; G01N2201/128
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
263 words
In a method for quantitatively assaying for an analyte in a biological liquid, comprising the steps of a) scanning with a light beam a test element bearing a sample of liquid having an analyte of unknown concentration; b) scanning a reference element with said light beam; c) detecting the amount of light diffusely reflected from said test element and said reference element; d) filtering the light beam before or after reflection from said elements and before detection, at a preselected wavelength that is the same for both said test element and said reference element; e) storing the detected amounts of diffuse reflection for each scanning of the reference element and test element, and f) comparing the detected reflectance of the test element with said stored reference detected reflectance to determine how much analyte is present, said reference element being scanned repeatedly, each time for a predetermined multiple of test elements scanned, a reference reflectance value being stored for each scanning; the improvement wherein said step e) comprises the steps of always selecting from said stored reference reflectance detections at said wavelength that which is either detected by step c) at a point of time closest to the time at which said test element is scanned at said wavelength in step a), or that which is computed to be the equivalent reference reflectance at the actual time the test element reflectance was read, and comparing said selected reference reflectance detection in said step f) with the detected test element reflectance, whereby the effect of drift in the reading of the reference element is minimized.
Claim 2
Dependent Claim
263 words
In a method for quantitatively assaying for an analyte in a biological liquid, comprising the steps of a) scanning with a light beam a test element bearing a sample of liquid having an analyte of unknown concentration; b) scanning a reference element with said light beam; c) detecting the amount of light diffusely reflected from said test element and said reference element; d) filtering the light beam before or after reflection from said elements and before detection, at a preselected wavelength that is the same for both said test element and said reference element; e) storing the detected amounts of diffuse reflection for each scanning of the reference element and test element, and f) comparing the detected reflectance of the test element with said stored reference detected reflectance to determine how much analyte is present, said reference element being scanned repeatedly, each time for a predetermined multiple of test elements scanned, a reference reflectance value being stored for each scanning; the improvement wherein said step e) comprises the steps of always selecting from said stored reference reflectance detections at said wavelength that which is either detected by step c) at a point of time closest to the time at which said test element is scanned at said wavelength in step a), or that which is computed to be the equivalent reference reflectance at the actual time the test element reflectance was read, and comparing said selected reference reflectance detection in said step f) with the detected test element reflectance, whereby the effect of drift in the reading of the reference element is minimized.
Claim 3
Dependent Claim
33 words
A method as defined in claim 1, wherein said test elements and said reference element are held on a rotating surface and are moved past said light beam repeatedly by rotating said surface.
Claim 4
Dependent Claim
21 words
A method as defined in claim 1, wherein each of said test elements is scanned five times at said selected wavelength.
Claim 5
Dependent Claim
19 words
A method as defined in claim 1, wherein said reference element is read at at least two different wavelengths.
Claim 6
Dependent Claim
250 words
In an analyzer for quantitatively assaying for an analyte of a biological liquid, the analyzer including a) means for scanning with a light beam a test element bearing a sample of liquid having an analyte of unknown concentration; b) means for scanning a reference element with said light beam; c) means for detecting the amount of light diffusely reflected from said test element and said reference element; d) means for filtering the light beam reflected from the elements at a preselected wavelength that is the same for the test element and the reference element; e) means for storing the detected amounts of diffuse reflection for each scanning of the reference element and of the test element; and f) means for comparing the detected reflectance of the test element with said stored reference detected reflectance at said selected wavelength to determine how much analyte is present, said reference element being scanned repeatedly, each time for a predetermined multiple of test elements scanned; the improvement wherein said analyzer further includes means for always selecting from the stored reference reflective detections, either the value detected at the point of time that is closest to the time at which said test element is scanned by said scanning means a), or that which is computed to be the equivalent reference reflectance at the actual time the test element reflectance was read, and for supplying this value to said comparing means f), whereby the effect of drift in the reading of the reference element is minimized.
Claim 7
Dependent Claim
250 words
In an analyzer for quantitatively assaying for an analyte of a biological liquid, the analyzer including a) means for scanning with a light beam a test element bearing a sample of liquid having an analyte of unknown concentration; b) means for scanning a reference element with said light beam; c) means for detecting the amount of light diffusely reflected from said test element and said reference element; d) means for filtering the light beam reflected from the elements at a preselected wavelength that is the same for the test element and the reference element; e) means for storing the detected amounts of diffuse reflection for each scanning of the reference element and of the test element; and f) means for comparing the detected reflectance of the test element with said stored reference detected reflectance at said selected wavelength to determine how much analyte is present, said reference element being scanned repeatedly, each time for a predetermined multiple of test elements scanned; the improvement wherein said analyzer further includes means for always selecting from the stored reference reflective detections, either the value detected at the point of time that is closest to the time at which said test element is scanned by said scanning means a), or that which is computed to be the equivalent reference reflectance at the actual time the test element reflectance was read, and for supplying this value to said comparing means f), whereby the effect of drift in the reading of the reference element is minimized.
Claim 8
Dependent Claim
33 words
An analyzer as defined in claim 5, and further including a rotating support for said elements and means for rotating said support so that each element is scanned by said light beam repeatedly.
Claim 9
Dependent Claim
21 words
An analyzer as defined in claim 5, wherein each of said test elements is scanned five times at said selected wavelength.
Claim 10
Dependent Claim
20 words
An analyzer as defined in claim 5, wherein said scanning means scans said reference element at least two different wavelengths.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-11-18 | 1995-05-20 | 1995-11-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-11-18 | 1999-05-20 | 1999-11-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-11-18 | 2003-05-20 | 2003-11-19 | $7700.00 | Window Closed / Lapsed |