US5066674A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carbamate inhibitors of cholesterol esterase and their use as hypolipidemic and hypocaloric agents
Assignee: University of Iowa Research Foundation
•
Filing: 1990-06-04
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Granted: 1991-11-19
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Expires: 2010-06-04
Abstract
Abstract Certain carbamate esters are used as inhibitors as cholesterol esterase and function as hypolipidemic and hypocaloric agents. The invention also relates to a method of decreasing the absorption of dietary cholesterol and fats through the wall of the intestinal tract.
Inventors
- 👤 Daniel M. Quinn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 09:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/27
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
70 words
A method of decreasing the absorption of dietary cholesterol and fats through the wall of the intestinal tract, said method comprising: administering to a mammal a small but cholesterol esterase inhibiting effective amount of a compound of the formula: ##STR6## wherein Z equals an aryl moiety selected from the group consisting of 2-naphthyl and p-acetamidophenyl, X and Y are oxygen, and R is a C 1 to C 8 alkyl.
Claim 2
Independent Claim
70 words
A method of decreasing the absorption of dietary cholesterol and fats through the wall of the intestinal tract, said method comprising: administering to a mammal a small but cholesterol esterase inhibiting effective amount of a compound of the formula: ##STR6## wherein Z equals an aryl moiety selected from the group consisting of 2-naphthyl and p-acetamidophenyl, X and Y are oxygen, and R is a C 1 to C 8 alkyl.
Claim 3
Dependent Claim
10 words
A carbamate ester of claim 1 wherein Z is 2-naphthyl.
Claim 4
Dependent Claim
39 words
A carbamate ester of claim 2 wherein an additional moiety W is attached to said 2-naphthyl, and W is selected from the group consisting of C 1 to C 8 alkyl, halides and C 1 to C 8 oxyalkyl.
Claim 5
Dependent Claim
14 words
A compound of claim 3 wherein R is C 1 to C 8 alkyl.
Claim 6
Dependent Claim
14 words
A compound of claim 3 wherein R is C 4 to C 8 alkyl.
Claim 7
Dependent Claim
57 words
A unit dosage pharmaceutical composition comprising a pharmaceutical carrier and from 0.01 mg to 1.0 mg/kg of body weight of a carbamate ester of the formula: ##STR7## wherein Z equals an aryl moiety selected from the group consisting of 2-naphthyl and p-acetamindophenyl, X and & are oxygen, and R is a C 1 to C 8 alkyl.
Claim 8
Dependent Claim
57 words
A unit dosage pharmaceutical composition comprising a pharmaceutical carrier and from 0.01 mg to 1.0 mg/kg of body weight of a carbamate ester of the formula: ##STR7## wherein Z equals an aryl moiety selected from the group consisting of 2-naphthyl and p-acetamindophenyl, X and & are oxygen, and R is a C 1 to C 8 alkyl.
Claim 9
Dependent Claim
10 words
A carbamate ester of claim 6 wherein Z is 2-naphthyl.
Claim 10
Dependent Claim
39 words
A carbamate ester of claim 7 wherein an additional moiety W is attached to said 2-naphthyl, and W is selected from the group consisting of C 1 to C 8 alkyl, halides and C 1 to C 8 oxyalkyl.
Claim 11
Dependent Claim
14 words
A compound of claim 8 wherein R is C 1 to C 8 alkyl.
Claim 12
Dependent Claim
14 words
A compound of claim 8 wherein R is C 4 to C 8 alkyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-11-18 | 1995-05-20 | 1995-11-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-11-18 | 1999-05-20 | 1999-11-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-11-18 | 2003-05-20 | 2003-11-19 | $7700.00 | Window Closed / Lapsed |