Purinyl tetrahydrofurans

Claim 1

A compound having the formula ##STR76## and pharmaceutically acceptable salts thereof wherein R 1 is ##STR77## wherein X 1 is hydrogen, amino, ##STR78## --N═CHN(X 8 ) 2 X 2 is methyl, fluoro, chloro, bromo, iodo, hydroxy, or amino, X 3 is hydrogen, chloro, or O-X 8 , X 4 is amino, chloro, ##STR79## or --N═CHN(X 8 ) 2 X 5 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy, or amino, R 2 and R 3 are independently hydrogen, --PO 3 H 2 , or ##STR80## the term "alkyl" refers to straight and branched chained groups of 1 to 10 carbons, the term "substituted alkyl" refers to alkyl groups having one or more substituents selected from the group consisting of halogen, amino, axiod, hydroxy, cyano, trialkylammonium (wherein each alkyl group has 1 to 6 carbons), alkoxy of 1 to 6 carbons, phenyl, substituted phenyl, and carboxy, and the term "substituted phenyl" refers to a phenyl substituted with one, two, or three groups selected from the group consisting of alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons, halogen, trifluoromethyl, amino, alkylamino of 1 to 6 carbons, halogen, trifluoromethyl, amino, alkylamino of 1 to 6 carbons, dialkylamino (wherein each alkyl group has 1 to 6 carbons), nitro, cyano, alkanoyloxy of 2 to 11 carbons, carboxy, carbonyl, and hydroxy.