US5055228A
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Process for the preparation of stable dispersions of at least one water-immiscible liquid phase in an aqueous phase
Assignee: L'Oréal SA
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Filing: 1988-03-14
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Granted: 1991-10-08
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Expires: 2008-03-14
Abstract
Abstract A process for the preparation of a stable emulsion of at least one water-immiscible liquid phase L in an aqueous phase D is described which comprises mixing the liquid phase or phases L with a dispersion of spheres in an aqueous phase D, the spheres having an average diameter of 0.025 to 5 microns and consisting of substantially concentric lipid laminae encapsulating an aqueous phase E between them, the lipid or lipids constituting the laminae being ionic or nonionic amphiphilic substances capable of forming a lamellar phase in water, and subjecting the whole to mechanical agitation so as to disperse the phase (or phases) L in the phase D in the form of droplets having an average diameter of 0.1 micron to a few microns.
Inventors
- 👤 Arlette Zabotto
- 👤 Jacqueline Griat
- 👤 Rose-Marie J. Handjani
- 👤 Guy G. Vanlerberghe
- 👤 Alain J. Ribier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 17:19
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0084; A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1272; A61K9/1277; B; B01; B01D; B01D19/00; B01D19/02; B01D19/04; B01D19/0404; C09; C09K; C09K23/00; C09K23/42; C11D17/00; C11D17/0008; C11D17/0026; D; D06; D06M; D06M7/00; C10; C10M; C10M2201/00; C10M2201/02; C10M2203/00; C10M2203/02; C10M2203/022; C10M2203/024; C10M2203/04; C10M2215/00; C10M2215/02; C10M2215/04; C10M2215/24; C10M2215/26; C10M2223/00; C10M2223/10; C10N; C10N2040/00; C10N2040/46; D06M2200/00; D06M2200/40; Y; Y10; Y10S; Y10S516/00; Y10S516/922; Y10S516/923; Y10S516/924; Y10S516/929
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
163 words
A process for the preparation of a stable dispersion comprising droplets of at least one water-immiscible liquid phase dispersed in a continuous aqueous phase, said aqueous phase having spheres dispersed therein whereby said droplets are stabilized in said dispersion by the presence therein of said spheres, said process comprising mixing by mechanical agitation said water-immiscible liquid phase with a dispersion of spheres in said continuous aqueous phase, said water-immiscible liquid phase consisting of a hydrocarbon, a halocarbon or polysiloxane, said spheres having an average diameter of 0.025 to 5 microns and consisting substantially of concentric lipid laminae encapsulating an aqueous phase between them, said lipid constituting said laminae consisting of an ionic or nonionic amphiphilic substance capable of forming a lamellar phase in water and said continuous aqueous phase contains, as the only amphiphilic substance, the said ionic or nonionic amphiphilic substance constituting the laminae of said spheres, all said ionic or nonionic amphiphilic substances being enclosed in the laminae of said spheres.
Claim 2
Dependent Claim
163 words
A process for the preparation of a stable dispersion comprising droplets of at least one water-immiscible liquid phase dispersed in a continuous aqueous phase, said aqueous phase having spheres dispersed therein whereby said droplets are stabilized in said dispersion by the presence therein of said spheres, said process comprising mixing by mechanical agitation said water-immiscible liquid phase with a dispersion of spheres in said continuous aqueous phase, said water-immiscible liquid phase consisting of a hydrocarbon, a halocarbon or polysiloxane, said spheres having an average diameter of 0.025 to 5 microns and consisting substantially of concentric lipid laminae encapsulating an aqueous phase between them, said lipid constituting said laminae consisting of an ionic or nonionic amphiphilic substance capable of forming a lamellar phase in water and said continuous aqueous phase contains, as the only amphiphilic substance, the said ionic or nonionic amphiphilic substance constituting the laminae of said spheres, all said ionic or nonionic amphiphilic substances being enclosed in the laminae of said spheres.
Claim 3
Dependent Claim
30 words
The process of claim 1 wherein said ionic amphiphilic substance is a natural phospholipid, a synthetic phospholipid, a cationic compound, a quaternary compound, an amphoteric compound or an anionic compound.
Claim 4
Dependent Claim
16 words
The process of claim 2 wherein said natural phospholipid is egg lecithin, soy lecithin or sphingomyelin.
Claim 5
Dependent Claim
14 words
The process of claim 2 wherein said synthetic phospholipid is dipalmitoyl-phosphatidyl-choline or hydrogenated lecithin.
Claim 6
Dependent Claim
24 words
The process of claim 2 wherein said quaternary compound is didodecyl dimethyl ammonium chloride, didodecyl dimethylammonium bromide, distearyl dimethylammonium chloride or distearyl dimethylammonium bromide.
Claim 7
Dependent Claim
119 words
The process of claim 1 wherein the nonionic amphiphilic substance is selected from the group consisting of (1) a straight or branched chain polyglycerol ether having the formulae ##STR5## wherein n represents a statistical average value of 1 to 6 and R represents a saturated or unsaturated, straight or branched chain aliphatic radical containing 12 to 30 carbon atoms, a hydrocarbon group of a lanolin alcohol or a 2-hydroxyalkyl group of a long chain α-diol; (2) a polyoxyethylenated fatty alcohol or polyoxyethylenated sterol; (3) an oxyethylenated or nonoxyethylenated polyol ester; (4) a natural or synthetic glycolipid; or (5) an ether or ester of a polyol containing two alkyl groups having at least 8 carbon atoms, as the hydrophobic residue.
Claim 8
Dependent Claim
22 words
The process of claim 1 wherein said water-immiscible liquid phase is added to said dispersion of spheres in said continuous aqueous phase.
Claim 9
Dependent Claim
25 words
The process of claim 1 wherein said water-immiscible liquid phase L is a compound having a molecular volume of at least 200 cm 3 /mol.
Claim 10
Dependent Claim
30 words
The process of claim 1 wherein said dispersion of spheres contains from 2 to 10 percent by weight of said amphiphilic substance, relative to the total weight of the dispersion.
Claim 11
Dependent Claim
18 words
The process of claim 1 wherein a single water-immiscible liquid phase is dispersed in the continous aqueous phase.
Claim 12
Dependent Claim
43 words
The process of claim 1 wherein the dispersion of spheres in the continuous aqueous phase D is obtained by introducing the aqueous phase E into a liquid lipid to form a plane lamellar phase, adding the aqueous phase D and agitating the whole.
Claim 13
Dependent Claim
23 words
The process of claim 1 in which in order to obtain the final dispersion the whole is agitated vigorously at about ambient temperature.
Claim 14
Dependent Claim
46 words
The process of claim 1 wherein said lipid constituting the laminae of said spheres is an ionic or nonionic natural or synthetic amphiphilic substance that contains, per molecule, one or more long hydrocarbon chains and one or more hydroxyl, ether, carboxyl, phosphate, amine or ammonium groups.
Claim 15
Dependent Claim
27 words
The process of claim 13 wherein the ionic amphiphilic substance is a natural or synthetic phospholipid, a cationic or quaternary compound or an amphoteric or anionic compound.
Claim 16
Dependent Claim
31 words
The process of claim 14 wherein the ionic amphiphilic substance is egg lecithin, soyalecithin, sphingomyelin, dipalmitoyl-phosphatidylcholine, hydrogenated lecithin, didodecyl dimethylammonium chloride, distearyl dimethylammonium chloride, didodecyl dimethylammonium bromide or distearyl dimethylammonium bromide.
Claim 17
Dependent Claim
119 words
The process of claim 13 wherein the nonionic amphiphilic substance is selected from the group consisting of (1) a linear or branched chain polyglycerol ether having the formulae ##STR6## wherein n represents a statistical average value of 1 to 6 and R represents a saturated or unsaturated, linear or branched chain aliphatic radical containing 12 to 30 carbon atoms, a hydrocarbon group of a lanolin alcohol or a 2-hydroxyalkyl group of a long chain α-diol; (2) a polyoxyethylenated fatty alcohol or polyoxyethylenated sterol; (3) an oxyethylenated or nonoxyethylenated polyol ester; (4) a natural or synthetic glycolipid; and (5) an ether or ester of a polyol containing two alkyl groups having at least 8 carbon atoms, as the hydrophobic residue.
Claim 18
Dependent Claim
22 words
The process of claim 1 wherein said continuous aqueous phase and said aqueous phase to be encapsulated in said spheres are isoosmotic.
Claim 19
Dependent Claim
22 words
The process of claim 17 wherein said continuous aqueous phase and said aqueous phase to be encapsulated in said spheres are identical.
Claim 20
Dependent Claim
36 words
The process of claim 1 wherein the water-immiscible liquid phase L is mixed with the dispersion of spheres in an amount ranging from 2 to 70 percent by weight, relative to the weight of the dispersion.
Claim 21
Dependent Claim
41 words
The process of claim 1 wherein the water-immiscible liquid phase L is introduced into the dispersion of spheres in an amount ranging from 20 to 2,000 percent by weight, relative to the weight of said amphiphilic substance contained in said dispersion.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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