US5054485A
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US
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Hemodynamically responsive system for and method of treating a malfunctioning heart
Assignee: Medtronic Inc
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Filing: 1990-06-01
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Granted: 1991-10-08
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Expires: 2010-06-01
Abstract
Abstract A system for and method of treating a malfunctioning heart is based on hemodynamics, the pressure in the right side of a patient's circulatory system being sensed. A first signal is developed representative of mean right atrial pressure (MRAP) and a second signal is developed representing right ventricular systolic pressure (RVSP). When the difference (or ratio) between MRAP and RVSP reaches at least a predetermined value, the combination being an indication of hemodynamic compromise, cardioversion/defibrillation is effected. In these cases, a heart rate criterion, for example a rate over 150 bpm, may also have to be met before cardioverting/defibrillation is initiated. Fixed or variable baselines against which the predetermined value is to be measured may be provided. Other hemodynamic parameters, such as RVDP, RVSP, MRVP and/or MAP could be used as one or another of the hemodynamic parameters.
Inventors
- 👤 Todd J. Cohen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 15:11
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/365; A61N1/36585; A61N1/38; A61N1/39; A61N1/3956; A61N1/3962; A61N1/39622
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
126 words
In a system for treating a malfunctioning heart of the type which includes storage means for storing electrical energy, electrode means for electrically coupling the storage means to the heart, determining means for determining either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure, means responsive to an output from the determining means for providing a signal whenever a relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure reaches at least a predetermined value indicative of hemodynamic compromise, and means responsive to the signal for charging and enabling discharge of the electrical energy stored by the storage means across the electrode means upon the relationship reaching at least the predetermined value.
Claim 2
Dependent Claim
126 words
In a system for treating a malfunctioning heart of the type which includes storage means for storing electrical energy, electrode means for electrically coupling the storage means to the heart, determining means for determining either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure, means responsive to an output from the determining means for providing a signal whenever a relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure reaches at least a predetermined value indicative of hemodynamic compromise, and means responsive to the signal for charging and enabling discharge of the electrical energy stored by the storage means across the electrode means upon the relationship reaching at least the predetermined value.
Claim 3
Dependent Claim
82 words
The system according to claim 1, wherein said determining means comprises means for determining either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure, and wherein said means responsive comprises means responsive to output from the determining means for providing a signal whenever a relationship between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure reaches at least the predetermined value.
Claim 4
Dependent Claim
43 words
The system according to claim 2, including means for establishing a fixed signal baseline representation of the predetermined value of the relationship between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure.
Claim 5
Dependent Claim
50 words
The system according to claim 2, including means for establishing a variable signal baseline representation of the predetermined value of the relationship between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure determined over a predetermined period of time.
Claim 6
Dependent Claim
59 words
The system according to claim 2, wherein said means responsive to output form the determining means comprises means responsive to output from the determining means for providing a signal whenever the difference between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure reaches at least a predetermined value.
Claim 7
Dependent Claim
59 words
The system according to claim 2, wherein said means responsive to output from the determining means comprises means responsive to output from the determining means for providing a signal whenever the ratio between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure reaches at least a given value.
Claim 8
Dependent Claim
39 words
The system according to claim 1, wherein the means responsive to the signal includes a microprocessor for developing a control signal to control the means for charging and enabling discharge of the electrical energy stored by the storage means.
Claim 9
Dependent Claim
53 words
The system according to claim 1, including electrical means for sensing heart rate and producing a distinctive control signal upon the heart rate exceeding a predetermined rate, and wherein the means responsive to the first-said signal enables discharge of the storage means upon contemporary presence of the first-said signal and the control signal.
Claim 10
Dependent Claim
37 words
The system according to claim 8, including antitachycardia pacemaking means, responsive solely to the distinctive control signal during periods when the first-said signal is absent, for delivering pacing signals to the heart whereby tachycardia may be overcome.
Claim 11
Dependent Claim
57 words
The system according to claim 8, including means responsive to output from said electrical means for sensing heart rate for developing a discharge-synchronizing signal synchronized to an R-wave, and wherein the means for discharging electrical energy across the electrode means and into the heart includes means for synchronizing the discharge with the discharge-synchronizing signal to effect cardioversion.
Claim 12
Dependent Claim
37 words
The system according to claim 10, wherein the means for discharging electrical energy across the electrode means and into the heart effects discharge on a nonsynchronized basis, in the absence of the synchronization signal, to effect defibrillation.
Claim 13
Dependent Claim
29 words
The system according to claim 1, including means for discharging electrical energy across said electrode means and into the heart effects discharge on a nonsynchronized basis to effect defibrillation.
Claim 14
Dependent Claim
38 words
The system according to claim 1, including means for establishing a fixed signal baseline representation of either the predetermined value of the relationship between right atrial pressure and right ventricular or central venous pressure and right ventricular pressure.
Claim 15
Dependent Claim
46 words
The system according to claim 1, including means for establishing a variable signal baseline representation of the predetermined value of the relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure determined over a predetermined period of time.
Claim 16
Dependent Claim
55 words
The system according to claim 1, wherein said means responsive to output from the determining means comprises means responsive to output from the determining means for providing a signal whenever the difference between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure reaches at least a predetermined value.
Claim 17
Dependent Claim
55 words
The system according to claim 1, wherein said means responsive to output form the determining means comprises means responsive to output form the determining means for providing a signal whenever either the ratio between right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure reaches at least a given value.
Claim 18
Dependent Claim
115 words
In a system for treating a malfunctioning heart of the type which includes storage means for storing electrical energy, electrode means for electrically coupling the storage means to the heart, determining means for determining a first hemodynamic parameter and a second hemodynamic parameter, means responsive to an output from the determining means for providing a signal whenever a relationship between the first and second hemodynamic parameters reaches at least a predetermined value indicative of hemodynamic compromise, and means responsive to the signal for charging and enabling discharge of the electrical energy stored by the storage means across the electrode means as at least one cardioverting pulse upon the relationship reaching at least the predetermined value.
Claim 19
Dependent Claim
115 words
In a system for treating a malfunctioning heart of the type which includes storage means for storing electrical energy, electrode means for electrically coupling the storage means to the heart, determining means for determining a first hemodynamic parameter and a second hemodynamic parameter, means responsive to an output from the determining means for providing a signal whenever a relationship between the first and second hemodynamic parameters reaches at least a predetermined value indicative of hemodynamic compromise, and means responsive to the signal for charging and enabling discharge of the electrical energy stored by the storage means across the electrode means as at least one cardioverting pulse upon the relationship reaching at least the predetermined value.
Claim 20
Dependent Claim
39 words
The system according to claim 17, wherein the means responsive to the signal includes a microprocessor for developing a control signal to control the means for charging and enabling discharge of the electrical energy stored by the storage means.
Claim 21
Dependent Claim
53 words
The system according to claim 17, including electrical means for sensing heart rate and producing a distinctive control signal upon the heart rate exceeding a predetermined rate, and wherein the means responsive to the first-said signal enables discharge of the storage means upon contemporary presence of the first-said signal and the control signal.
Claim 22
Dependent Claim
37 words
The system according to claim 19, including antitachycardia pacemaking means, responsive solely to the distinctive control signal during periods when the first-said signal is absent, for delivering pacing signals to the heart whereby tachycardia may be overcome.
Claim 23
Dependent Claim
57 words
The system according to claim 19, including means responsive to output from said electrical means for sensing heart rate for developing a discharge-synchronizing signal synchronized to an R-wave, and wherein the means for discharging electrical energy across the electrode means and into the heart includes means for synchronizing the discharge with the discharge-synchronizing signal to effect cardioversion.
Claim 24
Dependent Claim
37 words
The system according to claim 21, wherein the means for discharging electrical energy across the electrode means and into the heart effects discharge on a nonsynchronized basis, in the absence of the synchronization signal, to effect defibrillation.
Claim 25
Dependent Claim
29 words
The system according to claim 17, including means for discharging electrical energy across said electrode means and into the heart effects discharge on a nonsynchronized basis to effect defibrillation.
Claim 26
Dependent Claim
32 words
The system according to claim 17, including means for establishing a fixed signal baseline representation of the predetermined value of the relationship between the first hemodynamic parameter and the second hemodynamic parameter.
Claim 27
Dependent Claim
39 words
The system according to claim 17, including means for establishing a variable signal baseline representation of the predetermined value of the relationship between the first hemodynamic parameter and the second hemodynamic parameter determined over a predetermined period of time.
Claim 28
Dependent Claim
48 words
The system according to claim 17, wherein said means responsive to output from the determining means comprises means responsive to output from the determining means for providing a signal whenever the difference between the first hemodynamic parameter and the second hemodynamic parameter reaches at least a predetermined value.
Claim 29
Dependent Claim
48 words
The system according to claim 17, wherein said means responsive to output from the determining means comprises means responsive to output from the determining means for providing a signal whenever the ratio between the first hemodynamic parameter and the second hemodynamic parameter reaches at least a given value.
Claim 30
Independent Claim
88 words
A method of treating a malfunctioning heart comprising monitoring either right atrial pressure or central venous pressure, monitoring right ventricular pressure, determining if a relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure reaches at least predetermined value indicative of hemodynamic compromise, and delivering cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure has reached at least the predetermined value.
Claim 31
Independent Claim
88 words
A method of treating a malfunctioning heart comprising monitoring either right atrial pressure or central venous pressure, monitoring right ventricular pressure, determining if a relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure reaches at least predetermined value indicative of hemodynamic compromise, and delivering cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure has reached at least the predetermined value.
Claim 32
Dependent Claim
112 words
The method according to claim 28, wherein the steps of monitoring comprise monitoring mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure, wherein the determining step comprises determining if a relationship between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic pressure reaches at least the predetermined value, and wherein the delivering step comprises delivering cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between either mean right atrial pressure and right ventricular pressure or mean central venous pressure and right ventricular pressure has reached at least the predetermined value.
Claim 33
Dependent Claim
28 words
The method according to claim 29, including sensing heart rate, the step of delivering cardioverting/defibrillating electrical energy being taken only upon the heart rate exceeding a given rate.
Claim 34
Dependent Claim
15 words
The method according to claim 29, including establishing a fixed baseline for the predetermined value.
Claim 35
Dependent Claim
46 words
The method according to claim 29, including establishing a variable baseline for the predetermined value based on a relationship between either mean right atrial pressure and right ventricular systolic pressure or mean central venous pressure and right ventricular systolic determined over a predetermined period of time.
Claim 36
Dependent Claim
28 words
The method according to claim 28, including sensing heart rate, the step of delivering cardioverting/defibrillating electrical energy being taken only upon the heart rate exceeding a given rate.
Claim 37
Dependent Claim
15 words
The method according to claim 28, including establishing a fixed baseline for the predetermined value.
Claim 38
Dependent Claim
43 words
The method according to claim 28, including establishing a variable baseline for the predetermined value based on a relationship between either right atrial pressure and right ventricular pressure or central venous pressure and right ventricular pressure determined over a predetermined period of time.
Claim 39
Independent Claim
76 words
A method of treating a malfunctioning heart comprising monitoring a first hemodynamic parameter, monitoring a second hemodynamic parameter, determining if a relationship between the first hemodynamic parameter and the second hemodynamic parameter reaches at least predetermined value, and delivering at least one pulse of cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between the first hemodynamic parameter and the second hemodynamic parameter indicative of hemodynamic compromise has reached at least the predetermined value.
Claim 40
Independent Claim
76 words
A method of treating a malfunctioning heart comprising monitoring a first hemodynamic parameter, monitoring a second hemodynamic parameter, determining if a relationship between the first hemodynamic parameter and the second hemodynamic parameter reaches at least predetermined value, and delivering at least one pulse of cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between the first hemodynamic parameter and the second hemodynamic parameter indicative of hemodynamic compromise has reached at least the predetermined value.
Claim 41
Dependent Claim
28 words
The method according to claim 36, including sensing heart rate, the step of delivering cardioverting/defibrillating electrical energy being taken only upon the heart rate exceeding a given rate.
Claim 42
Dependent Claim
15 words
The method according to claim 36, including establishing a fixed baseline for the predetermined value.
Claim 43
Dependent Claim
36 words
The method according to claim 36, including establishing a variable baseline for the predetermined value based on a relationship between the first hemodynamic parameter and the second hemodynamic parameter determined over a predetermined period of time.
Claim 44
Dependent Claim
18 words
The method according to claim 36, wherein at least one of the hemodynamic parameters is a nonpressure parameter.
Claim 45
Dependent Claim
35 words
The method according to claim 36, wherein the at least one parameter is mixed venous O 2 saturation, pH, body temperature, blood temperature, cardiac output, cardiac impedance, lactic acid level or a blood ion level.
Claim 46
Dependent Claim
108 words
In a system for treating a malfunctioning heart of the type which includes storage means for storing electrical energy and electrode means for electrically coupling the storage means to the heart, an improvement comprising determining means for determining a first hemodynamic parameter and a second hemodynamic parameter in a circulatory system, and means for enabling discharge of the electrical energy stored by the storage means across the electrode means as at least one pulse of cardioverting/defibrillating energy upon output from the determining means indicating that a relationship between the first hemodynamic parameter and the second hemodynamic parameter has reached at least a predetermined value indicative of hemodynamic compromise.
Claim 47
Dependent Claim
108 words
In a system for treating a malfunctioning heart of the type which includes storage means for storing electrical energy and electrode means for electrically coupling the storage means to the heart, an improvement comprising determining means for determining a first hemodynamic parameter and a second hemodynamic parameter in a circulatory system, and means for enabling discharge of the electrical energy stored by the storage means across the electrode means as at least one pulse of cardioverting/defibrillating energy upon output from the determining means indicating that a relationship between the first hemodynamic parameter and the second hemodynamic parameter has reached at least a predetermined value indicative of hemodynamic compromise.
Claim 48
Independent Claim
66 words
A method of treating a malfunctioning heart comprising monitoring at least two hemodynamic parameters in a circulatory system, determining if a relationship between the first hemodynamic parameter and the second hemodynamic parameter reach at least a predetermined value indicative of hemodynamic compromise, and delivering cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between the hemodynamic parameters has reached at least the predetermined value.
Claim 49
Independent Claim
66 words
A method of treating a malfunctioning heart comprising monitoring at least two hemodynamic parameters in a circulatory system, determining if a relationship between the first hemodynamic parameter and the second hemodynamic parameter reach at least a predetermined value indicative of hemodynamic compromise, and delivering cardioverting/defibrillating electrical energy to the heart upon determining that the relationship between the hemodynamic parameters has reached at least the predetermined value.
References Cited (Backward Citations)
US3614954A
Cited
US3942536B1
Cited
US3942536A
Cited
US4316472A
Cited
US4316472C1
Cited
US4572191A
Cited
US4572191B1
Cited
US4184493A
Cited
US4202340A
Cited
US4164946A
Cited
US4210149A
Cited
US4223678A
Cited
US4291699A
Cited
US4254775A
Cited
US4323075A
Cited
US4403614A
Cited
US4295474A
Cited
US4300567A
Cited
US4303075A
Cited
US4576170A
Cited
US4475551A
Cited
US4440172A
Cited
US4407288A
Cited
US4407288B1
Cited
US4693253A
Cited
US4393877A
Cited
US4523595A
Cited
US4427011A
Cited
US4614192A
Cited
US4548203A
Cited
US4559946A
Cited
US4562846A
Cited
US4548209A
Cited
US4592367A
Cited
US4708143A
Cited
US4802481A
Cited
US4625730A
Cited
US4730619A
Cited
US4873980A
Cited
US4867160A
Cited
US4662377A
Cited
US4770177A
Cited
US4803987A
Cited
US4733667A
Cited
US4799493A
Cited
US4895151A
Cited
US4967748A
Cited
US4774950A
Cited
US4819662A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-10-07 | 1995-04-08 | 1995-10-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-07 | 1999-04-08 | 1999-10-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-07 | 2003-04-08 | 2003-10-08 | $7700.00 | Window Closed / Lapsed |