US5053228A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric temperature sensitive drug carrier
Assignee: WR Grace and Co Conn
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Filing: 1990-07-13
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Granted: 1991-10-01
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Expires: 2010-07-13
Abstract
Abstract The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier is a liquid when administered and becomes solid in the body, in which state it is capable of releasing a drug continuously. The drug carrier has a lower LCST than human body temperature.
Inventors
- 👤 Yuichi Mori
- 👤 Toshiya Sakai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:50
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
72 words
A method for administering a slow release drug to a patient comprising: (a) selecting a temperature-sensitive polymeric compound, (b) selecting a drug, (c) forming a hydrolyzable covalent bond between said polymeric compound and said drug, wherein the resulting polymer/drug compound has a lower LCST than body temperature, and (d) administering said polymer/drug compound to a patient wherein the liquid solution of said polymer/drug compound is at a temperature lower than body temperature.
Claim 2
Independent Claim
72 words
A method for administering a slow release drug to a patient comprising: (a) selecting a temperature-sensitive polymeric compound, (b) selecting a drug, (c) forming a hydrolyzable covalent bond between said polymeric compound and said drug, wherein the resulting polymer/drug compound has a lower LCST than body temperature, and (d) administering said polymer/drug compound to a patient wherein the liquid solution of said polymer/drug compound is at a temperature lower than body temperature.
Claim 3
Dependent Claim
27 words
A method of claim 1 wherein said polymeric compound in a poly(N-substituted acrylamide), a poly(N-substituted methacrylamide), their copolymers, a polymethylvinyl ether or a partially acetylated polyvinyl alcohol.
Claim 4
Dependent Claim
27 words
The method of claim 1 wherein said covalent bond is an ester bond, amide bond, urethane bond, urea bond, carbamate bond, thiol ester bond or hydrazone bond.
Claim 5
Dependent Claim
28 words
The method of claim 1 wherein said drug is an anti-cancer agent, hormone, antibiotic, narcotic antagonist, analgesic, anti-inflammatory agent, hypotensive, anti-depressant, anti-epileptic agent, anti-malarial agent, anti-helminthic or immunoactivator.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-30 | 1995-04-01 | 1995-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-30 | 1999-04-01 | 1999-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-30 | 2003-04-01 | 2003-10-01 | $7700.00 | Window Closed / Lapsed |