US5051408A
Expired / Lapsed
US
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Inulin compositions in gamma polymorphic form
Assignee: Australian National University
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Filing: 1990-03-30
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Granted: 1991-09-24
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Expires: 2010-03-30
Abstract
Abstract A process for preparing gamma inulin comprising the steps of (a) recrystallizing crude inulin from water at a temperature below 37° C. to obtain a suspension, (b) heating the suspension at a temperature of from about 25° to 45° C. for about 1-3 days, (c) further heating the suspension at a temperature of about 40° to 55° C. for about 0.5 to 1.5 hours, and (d) isolating insoluble gamma inulin from the suspension. A composition comprising particles of inulin or an inulin derivative in the gamma polymorphic form is characterized in that the particles have a low rate of solution in aqueous media above 30° C., particularly above 37° C. The composition is effective as the active component of an immunotherapeutic preparation for activation of the alternative pathway of complement, or for antitumor treatment.
Inventors
- 👤 Peter Dodd Cooper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:09
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61P; A61P35/00; A61P37/00; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0051; C08B37/0054
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
25 words
A composition comprising particles of inulin, wherein said particles are in the gamma polymorphic form and are virtually insoluble in aqueous media at 37° C.
Claim 2
Dependent Claim
25 words
A composition comprising particles of inulin, wherein said particles are in the gamma polymorphic form and are virtually insoluble in aqueous media at 37° C.
Claim 3
Dependent Claim
16 words
A composition according to claim 1, wherein said inulin has a molecular weight greater than 8,000.
Claim 4
Dependent Claim
38 words
A composition according to claim 1, comprising particles of gamma inulin, wherein the gamma inulin has a molecular weight in the range of from about 8,000 to about 16,000 and is virtually insoluble in water at 37° C.
Claim 5
Dependent Claim
25 words
A composition according to claim 3, wherein said gamma inulin is in the form of a stable pure suspension of particles <1 μm in diameter.
Claim 6
Dependent Claim
52 words
An immunotherapeutic preparation for activation of the alternate pathway of complement (APC) in a human or animal body, which comprises as the active component thereof particles of inulin in the gamma polymorphic form, wherein said particles are virtually insoluble in aqueous media at 37° C.; and a pharmaceutically acceptable diluent or carrier.
Claim 7
Dependent Claim
52 words
An immunotherapeutic preparation for activation of the alternate pathway of complement (APC) in a human or animal body, which comprises as the active component thereof particles of inulin in the gamma polymorphic form, wherein said particles are virtually insoluble in aqueous media at 37° C.; and a pharmaceutically acceptable diluent or carrier.
Claim 8
Dependent Claim
15 words
A preparation according to claim 5, wherein said active component comprises particles of gamma inulin.
Claim 9
Dependent Claim
16 words
A preparation according to claim 5, wherein said carrier or diluent is a sterile, aqueous vehicle.
Claim 10
Dependent Claim
14 words
A preparation according to claim 7, wherein said aqueous vehicle is an isotonic solution.
Claim 11
Dependent Claim
12 words
A preparation according to claim 5 in a form suitable for injection.
Claim 12
Dependent Claim
19 words
A preparation according to claim 5 in a form suitable for oral, rectal, vaginal, topical, nasal or ocular administration.
Claim 13
Dependent Claim
17 words
A preparation according to claim 5, further comprising a second active component which is an immune modulator.
Claim 14
Dependent Claim
23 words
A preparation according to claim 4, wherein said immune modulator is a vaccinating antigen, an antigenic peptide sequence, or an anti-iodiotype immune globulin.
Claim 15
Dependent Claim
48 words
A preparation according to claim 11, wherein said immune modulator is an interleukin or an interferon or tumor necrosis factor or other lymphokine, or thymocyte stimulator or other thymus stimulating hormone, a muramyl peptide or other microbial component or whole microbial component or whole microbe, or an endotoxin.
Claim 16
Dependent Claim
41 words
A method for the activation of the alternative pathway of complement (APC) in a human or animal body, which comprises administering to the human or animal body an effective amount for said activation of an immunotherapeutic preparation according to claim 5.
Claim 17
Dependent Claim
45 words
A method for enhancement of an immune response in a human or animal body to which has been administered an immune modulator which comprises administering to the human or animal body an effective amount for said enhancement of an immunotherapeutic preparation according to claim 5.
Claim 18
Dependent Claim
48 words
A method for enhancement of the effect of administration of a vaccinating antigen, an antigenic peptide sequence, or an anti-idiotype immune globulin, in a human or animal body which comprises administering as an adjuvant an effective amount for said enhancement of an immunotherapeutic preparation according to claim 5.
References Cited (Backward Citations)
No citation records indexed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-23 | 1995-03-25 | 1995-09-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-23 | 1999-03-25 | 1999-09-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-23 | 2003-03-25 | 2003-09-24 | $7700.00 | Window Closed / Lapsed |