Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance

Claim 1

Pharmaceutical composition having relaxing activity, for example the treatment of heart and vascular diseases which contains a nitrate ester as active substance, characterized in that said ester ##STR4## , wherein R 0 represents H,OH which may be esterified by substituted or unsubstituted aliphatic or (hetero)aromatic carboxylic acid, or a group ##STR5## in which later formula R 3 represents H or a substituted or unsubstituted (hetero)aromatic group, but is possibly lacking in case X 2 represents a triple bond, R 4 represents H, OH or straight or branched alkyl, alkenyl, alkynyl or alkoxy or cyclopropyl, or is identical to R 3 , but is possibly lacking in case X 2 represents a triple bond, R 5 represents H or straight or branched alkyl, but is lacking in case X 2 represents a double or triple bond, X 1 represents a single bond, methylene, a substituted or unsubstituted carboxamide group or amino group, O or S, but is lacking in case X 2 represents a triple bond and X 2 represents a single bond, a double bond (in which case R 5 is then lacking), or a triple bond (in which case R 5 and either R 3 --X, or R 4 are then lacking), a substituted or unsubstituted carboxamide group or amino group, O or S, R 1 represents straight or branched alkylene having 1-8 carbon atoms in a straight chain, cycloalkylene having 3-7 carbon atoms, bicycloalkylene having 5-12 carbon atoms, a 1,4:3,6-dianhydrohexitrolylene group or a derivative from said group, or mono-, di- or tri-alkylene substituted cycloalkylene, R 2 represents H, OH, straight or branched alkyl or alkylphenyl, where phenyl has the same substitution possibilities as R 3 , or substituted or unsubstituted thioxanethenyl, substituted or unsubstituted benzocycloalkanyl having 5-7 carbon atoms in the cycloalkanyl chain, substituted or unsubstituted benzocycloalkenyl having 5-7 carbon atoms in the cycloalkenyl chain, substituted or unsubstituted dibenzocycloalkanyl having 5-7 carbon atoms in the cycloalkanyl chain, or substituted or unsubstituted dibenzocycloalkenyl having 5-7 carbon atoms in the cycloalkyl chain and n is 1, 2 or 3, or a salt derived from such as ester.