US5043429A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Protein fragments containing Factor VIII binding domain of von Willebrand Factor
Assignee: Scripps Research Institute
•
Filing: 1987-05-01
•
Granted: 1991-08-27
•
Expires: 2007-05-01
Abstract
Abstract Peptides which inhibit the binding of von Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain. Improved methods of preparing Factor VIII.
Inventors
- 👤 Theodore S. Zimmerman
- 👤 Paul A. Foster
- 👤 Carol A. Fulcher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:03
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/36; A; A61; A61P; A61P7/00; A61P7/02; C07K14/00; C07K14/435; C07K14/745; C07K14/755
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
82 words
A 29 kDa von Willebrand Factor polypeptide having an amino acid sequence which is a sequential subset of the following sequence: ##STR3## wherein the N-terminal amino acid of said polypeptide is selected from amino acid 3 (Ser) through 44 (Gly) of said sequence and the C-terminal amino acid of said polypeptide is selected from about amino acid 244 (Leu) through 285 (Asp) of said sequence, said polypeptide further characterized by its ability to inhibit binding of von Willebrand Factor to Factor VIII.
Claim 2
Dependent Claim
82 words
A 29 kDa von Willebrand Factor polypeptide having an amino acid sequence which is a sequential subset of the following sequence: ##STR3## wherein the N-terminal amino acid of said polypeptide is selected from amino acid 3 (Ser) through 44 (Gly) of said sequence and the C-terminal amino acid of said polypeptide is selected from about amino acid 244 (Leu) through 285 (Asp) of said sequence, said polypeptide further characterized by its ability to inhibit binding of von Willebrand Factor to Factor VIII.
Claim 3
Dependent Claim
31 words
A polypeptide according to claim 1 wherein said polypeptide has the amino-terminal sequence beginning with amino-terminal amino acid residue 3 Ser and ending approximately with carboxy-terminal amino acid residue 244 Leu.
Claim 4
Dependent Claim
31 words
A polypeptide according to claim 1 wherein said polypeptide has the amino-terminal sequence beginning with amino-terminal amino acid residue 24 Glu and ending approximately with carboxy-terminal amino acid residue 265 Ser.
Claim 5
Dependent Claim
30 words
A polypeptide according to claim 1 wherein said polypeptide has the amino-terminal sequence beginning with amino-terminal acid residue 44 Gly and ending approximately with carboxyl-terminal amino acid residue 285 Asp.
Claim 6
Dependent Claim
11 words
A von Willebrand Factor polypeptide having the amino acid sequence: ##STR4##
Claim 7
Dependent Claim
11 words
A von Willebrand Factor polypeptide having the amino acid sequence: ##STR4##
Claim 8
Dependent Claim
45 words
A peptide of claims 1, 2, 3, 4, or 5 further characterized by binding with the monoclonal anti-vWF antibody C3 secreted by the hybridoma ATCC Designation No. HB9425 capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain.
References Cited (Backward Citations)
US4661471A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-26 | 1995-02-25 | 1995-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-26 | 1999-02-25 | 1999-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-26 | 2003-02-25 | 2003-08-27 | $7700.00 | Window Closed / Lapsed |