US5041446A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for inhibiting the development of tolerance in the analgesic treatment with morphine
Assignee: Angelini Acraf SpA
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Filing: 1989-06-06
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Granted: 1991-08-20
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Expires: 2009-06-06
Abstract
Abstract Method for inhibiting the development of tolerance in the analgesic treatment with morphine of a subject in need of said treatment, comprising administering systemically and contemporarily an effective analgesic dose of morphine and an amount of dapiprazole of from 1/4 to 1 part by weight to 1 part by weight of said analgesic dose of morphine. Pharmaceutical composition useful in the said method.
Inventors
- 👤 Bruno Silvestrini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61P; A61P25/00; A61P25/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
57 words
A method for inhibiting the development of tolerance in the analgesic treatment with morphine of a subject in need of said treatment, comprising administering systemically and contemporarily an effective analgesic dose of morphine and an amount of dapiprazole of from 1/4 to 1 part by weight to 1 part by weight of said analgesic dose of morphine.
Claim 2
Independent Claim
57 words
A method for inhibiting the development of tolerance in the analgesic treatment with morphine of a subject in need of said treatment, comprising administering systemically and contemporarily an effective analgesic dose of morphine and an amount of dapiprazole of from 1/4 to 1 part by weight to 1 part by weight of said analgesic dose of morphine.
Claim 3
Dependent Claim
20 words
A method as in claim 1, wherein the said analgesic dose of morphine is of from 8 to 20 mg.
Claim 4
Dependent Claim
42 words
A pharmaceutical composition comprising from 2 to 20 mg of dapiprazole or the equivalent amount of a pharmaceutically acceptable acid addition salt effective in inhibiting the development of tolerance, and an effective analgesic amount of morphine together with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
42 words
A pharmaceutical composition comprising from 2 to 20 mg of dapiprazole or the equivalent amount of a pharmaceutically acceptable acid addition salt effective in inhibiting the development of tolerance, and an effective analgesic amount of morphine together with a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
31 words
A composition as in claim 3 wherein the amount of dapiprazole is of from 1/4 to 1 part by weight to 1 part by weight of said analgesic amount of morphine.
References Cited (Backward Citations)
US4252721A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-19 | 1995-02-18 | 1995-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-19 | 1999-02-18 | 1999-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-19 | 2003-02-18 | 2003-08-20 | $7700.00 | Window Closed / Lapsed |