US5041380A
Expired / Lapsed
US
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Tetrapeptide
Assignee: Sanford Burnham Prebys Medical Discovery Institute
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Filing: 1988-09-09
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Granted: 1991-08-20
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Expires: 2008-09-09
Abstract
Abstract The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.
Inventors
- 👤 Erkki Ruoslahti
- 👤 Michael Pierschbacher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:43
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61K; A61K38/00; A61K38/04; A61K38/07; A61K38/08; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
39 words
A method of inhibiting platelet aggregation comprising contacting platelets with a polypeptide including the amino acid sequence Arg-Gly-Asp-R, wherein R is an amino acid such that the polypeptide has cell attachment-promoting activity, in sufficient concentration to inhibit platelet aggregation.
Claim 2
Independent Claim
39 words
A method of inhibiting platelet aggregation comprising contacting platelets with a polypeptide including the amino acid sequence Arg-Gly-Asp-R, wherein R is an amino acid such that the polypeptide has cell attachment-promoting activity, in sufficient concentration to inhibit platelet aggregation.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein R is Ser, Thr, or Cys.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-19 | 1995-02-18 | 1995-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-19 | 1999-02-18 | 1999-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-19 | 2003-02-18 | 2003-08-20 | $7700.00 | Window Closed / Lapsed |