US5041291A
Expired / Lapsed
US
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Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled deivery of active ingredient
Assignee: Hoechst AG
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Filing: 1989-09-05
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Granted: 1991-08-20
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Expires: 2009-09-05
Abstract
Abstract The invention relates to biodegradable poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR1## in which n, m, x, y, z, R and R' have the indicated meanings, and to a process for their preparation and to the use thereof for depot formulations with controlled delivery of active ingredient.
Inventors
- 👤 Hubert Bader
- 👤 Diether Ruppel
- 👤 Axel Walch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:59
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10; A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/2045; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
148 words
A method of preparing a biodegradable active ingredient depot formulation with controlled delivery of a biologically active ingredient which comprises incorporating a biologically active ingredient into a controlled release agent which contains a poly (hydroxyalkyl) amino dicarboxylic acid derivative of the formula I ##STR6## in which n is 1 or 2, m is 2 to 6, x and y are 1 to 400, and z is 0 to 40, and in which the radicals R and R' are identical or, independently of one another, different and denote branched or unbranched, saturated or unsaturated alkyl, cycloalkyl, alkoxy or cycloalkyloxy groups having a total of 1-22 carbon atoms in the alkyl moiety, the alkyl moiety is not interrupted or is interrupted by a carbonyloxy group, or biologically inactive steroid alcohols bonded via their hydroxyl groups, there being random distribution in the polymer of the monomer units placed in square brackets.
Claim 2
Independent Claim
148 words
A method of preparing a biodegradable active ingredient depot formulation with controlled delivery of a biologically active ingredient which comprises incorporating a biologically active ingredient into a controlled release agent which contains a poly (hydroxyalkyl) amino dicarboxylic acid derivative of the formula I ##STR6## in which n is 1 or 2, m is 2 to 6, x and y are 1 to 400, and z is 0 to 40, and in which the radicals R and R' are identical or, independently of one another, different and denote branched or unbranched, saturated or unsaturated alkyl, cycloalkyl, alkoxy or cycloalkyloxy groups having a total of 1-22 carbon atoms in the alkyl moiety, the alkyl moiety is not interrupted or is interrupted by a carbonyloxy group, or biologically inactive steroid alcohols bonded via their hydroxyl groups, there being random distribution in the polymer of the monomer units placed in square brackets.
Claim 3
Dependent Claim
18 words
A method according to claim 1 wherein a biologically active substance is encapsulated by said controlled release agent.
Claim 4
Dependent Claim
22 words
A method according to claim 1 wherein the controlled release agent further contains other biodegradable and/or biocompatible polymers or physiologically acceptable auxiliaries.
Claim 5
Dependent Claim
17 words
A method according to claim 1 wherein the controlled release agent further contains physiologically acceptable polymer plasticizers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-19 | 1995-02-18 | 1995-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-19 | 1999-02-18 | 1999-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-19 | 2003-02-18 | 2003-08-20 | $7700.00 | Window Closed / Lapsed |