US5039805A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel benzoic and phenylacetic acid derivatives
Assignee: F Hoffmann La Roche AG
•
Filing: 1989-11-24
•
Granted: 1991-08-13
•
Expires: 2009-11-24
Abstract
Abstract The compound of the formula <IMAGE> I <IMAGE> wherein R1, R2 and R3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and arteriosclerosis as well as for the treatment of tumours.
Inventors
- 👤 Leo Alig
- 👤 Albrecht Edenhofer
- 👤 Marcel Muller
- 👤 Arnold Trzeciak
- 👤 Thomas Weller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:32
CPC Classifications
C; C07; C07C; C07C237/00; C07C237/28; C07C237/42; A; A61; A61P; A61P29/00; A61P7/00; A61P7/02; A61P9/00; A61P9/06; A61P9/08; A61P9/10; C07C237/40; C07C237/44; C07C257/00; C07C257/10; C07C257/18; C07C271/00; C07C271/06; C07C271/08; C07C271/10; C07C271/22; C07C279/00; C07C279/04; C07C279/14; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/34; C07K; C07K5/00; C07K5/02; C07K5/0205; C07C2601/00; C07C2601/12; C07C2601/14; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/08
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
111 words
A compound of formula ##STR11## wherein R e is H or amidino; R 2 is H, CH 3 , OCH 3 , NO 2 , halogen, NH 2 , --NHCO--phenylene--COOH, --NHCO(CH 2 ) 1-4 --COOH, OR h , --CH 2 CH 2 OR h , --CH 2 CH 2 OCH 2 CH 2 OR h or --CH 2 COOR h wherein R h is H or lower alkyl; R 3 is H, --CONH 2 , --COR f , --COOR g or aryl wherein R f is the residue of an α-aminocarboxylic acid attached via the amino group or an ester or amide thereof, and R g is H or lower alkyl.
Claim 2
Dependent Claim
111 words
A compound of formula ##STR11## wherein R e is H or amidino; R 2 is H, CH 3 , OCH 3 , NO 2 , halogen, NH 2 , --NHCO--phenylene--COOH, --NHCO(CH 2 ) 1-4 --COOH, OR h , --CH 2 CH 2 OR h , --CH 2 CH 2 OCH 2 CH 2 OR h or --CH 2 COOR h wherein R h is H or lower alkyl; R 3 is H, --CONH 2 , --COR f , --COOR g or aryl wherein R f is the residue of an α-aminocarboxylic acid attached via the amino group or an ester or amide thereof, and R g is H or lower alkyl.
Claim 3
Dependent Claim
17 words
The compound of claim 1 selected from the group consisting of: N-[N-[m-(1-amidino-4-piperidinecarboxamido)benzoyl]-L-α-aspartyl]-3-phenyl-L-alanine trifluoroacetate, N-[m-[3-(4-piperidinyl)propionamido]benzoyl]-β-alanine and N-[m-[3-(1-amidino-4-piperidinyl)propionamido]benzoyl]-β-alanine trifluoroacetate.
Claim 4
Dependent Claim
50 words
A compound of the formula ##STR12## wherein R 4 is hydrogen or a readily cleavable ester group and R e , R 2 and R 3 are as in claim 1 wherein the molecule contains at least one readily cleavable ester group or a protected amino, amidino or guanidino group.
References Cited (Backward Citations)
US4578079A
Cited
EP0220957A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-12 | 1995-02-11 | 1995-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-12 | 1999-02-11 | 1999-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-12 | 2003-02-11 | 2003-08-13 | $7700.00 | Window Closed / Lapsed |