US5037737A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analysis by sensor placement in recprocating flow
Assignee: APEC Inc A DE CORP
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Filing: 1988-06-29
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Granted: 1991-08-06
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Expires: 2008-06-29
Abstract
Abstract A method and apparatus for analyzing a sample to determine an analyte content has a means for sensing said analyte positioned between a first and second transducer. The analyte or derivatives thereof are reciprocated between the first and second transducer to reciprocate at the sensor and allow instantaneous sensing of an indication of said analyte's presence at a point between said first and second transducer. Rapid analysis can be carried out in many different systems including for example where the transducers are enzyme reactors and the analytes are body metabolites.
Inventors
- 👤 Stanley M. Liffmann
- 👤 Humayun Qureshi
- 👤 John D. Czaban
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 09:56
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/60; C12M; C12M21/00; C12M21/18; C12Q1/54; Y; Y10; Y10S; Y10S435/00; Y10S435/817; Y10T; Y10T436/00; Y10T436/11; Y10T436/117497
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
77 words
A method of analyzing a fluid sample to determine an analyte content thereof, said method comprising flowing said sample to a first chemical reactor and then to a second chemical reactor and reciprocating said sample between said first and second chemical reactor, and sensing the presence of said analytes conversion by said reactors into a detectable substance, said sensing carried out at a point in the flowpath of said fluid between said first and second chemical reactor.
Claim 2
Independent Claim
77 words
A method of analyzing a fluid sample to determine an analyte content thereof, said method comprising flowing said sample to a first chemical reactor and then to a second chemical reactor and reciprocating said sample between said first and second chemical reactor, and sensing the presence of said analytes conversion by said reactors into a detectable substance, said sensing carried out at a point in the flowpath of said fluid between said first and second chemical reactor.
Claim 3
Dependent Claim
29 words
A method in accordance with the method of claim 1 wherein said reactors are immobilized enzyme reactors for reacting said analyte and said analyte is reacted in said reactors.
Claim 4
Dependent Claim
48 words
A method in accordance with the method of claim 1 wherein said sensing is carried out by a sensor which has a conduit about it defining a dead space volume and each of said reactors comprises a reactor volume of at least four times said dead space volume.
Claim 5
Dependent Claim
24 words
A method in accordance with the method of claim 3 wherein each said reactor volume is at least eight times said dead space volume.
Claim 6
Dependent Claim
24 words
A method in accordance with the method of claim 4 wherein said method is carried out in a time between 0 and 5 minutes.
Claim 7
Dependent Claim
24 words
A method in accordance with the method of claim 5 wherein said analyte is glucose and said time is between 0 and 45 seconds.
Claim 8
Dependent Claim
15 words
A method in accordance with the method of claim 1 wherein said analyte is cholesterol.
Claim 9
Dependent Claim
18 words
A method in accordance with the method of claim 1 wherein said reactors comprise at least one dialyzer.
Claim 10
Independent Claim
68 words
A method of rapidly sensing the occurrence of a chemical reaction in a fluid, said method comprising, flowing said fluid to a first chemical reactor and then to a second chemical reactor and reciprocating said fluid in a flow path between said first and second chemical reactor, while sensing at a point in said flow path between said reactors the instantaneous rate of reaction occurring in said fluid.
Claim 11
Independent Claim
68 words
A method of rapidly sensing the occurrence of a chemical reaction in a fluid, said method comprising, flowing said fluid to a first chemical reactor and then to a second chemical reactor and reciprocating said fluid in a flow path between said first and second chemical reactor, while sensing at a point in said flow path between said reactors the instantaneous rate of reaction occurring in said fluid.
Claim 12
Dependent Claim
14 words
A method in accordance with claim 9 wherein said reactors are immobilized enzyme reactors.
Claim 13
Dependent Claim
15 words
A method in accordance with claim 10 wherein said sensor is an O 2 sensor.
Claim 14
Dependent Claim
19 words
A method in accordance with claim 11 and further comprising determining the concentration of an analyte in said fluid.
Claim 15
Dependent Claim
12 words
A method in accordance with claim 12 wherein said analyte is glucose.
Claim 16
Dependent Claim
13 words
A method in accordance with claim 12 wherein said analyte is total cholesterol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-05 | 1995-02-04 | 1995-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-05 | 1999-02-04 | 1999-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-05 | 2003-02-04 | 2003-08-06 | $7700.00 | Window Closed / Lapsed |