Compositions for the control of hyperlipidemia

Claim 1

A pharmaceutical compound for controlling hyperlipidemia in mammals having the following structural formula: ##STR6## wherein R 1 hydrogen, a C 1 to C 18 alkyl or substituted alkyl, a C 2 to C 18 alkenyl or substituted alkenyl, a C 2 to C 18 alkynyl or substituted alkynyl, a C 4 to C 10 cycloalkyl or substituted cycloalkyl, a C 4 to C 10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, --CO--R 9 or --Y--CO--R 9 ; R 5 and R 6 be the same or different and are each hydrogen, a C 1 to C 18 alkyl or substituted alkyl, a C 2 to C 18 alkenyl or substituted alkenyl, a C 2 to C 18 alkynyl or substituted alkynyl, a C 4 to C 10 cycloalkyl or substituted cycloalkyl, a C 4 to C 10 cycloalkyl or substituted cycloalkenyl, phenyl or substituted phenyl, phenalkyl, --CO--R 9 , or --Y--CO--R 9 , with the proviso that R 5 and R 6 are not both aromatic; R 9 is hydrogen, a C 1 to C 5 alkyl or substituted alkyl, a C 2 to C 5 alkenyl or substituted alkenyl, a C 2 to C 5 alkynyl or substituted alkynyl, phenyl or substituted phenyl, phenoxy or substituted phenoxy, a C 1 to C 5 alkoxy or substituted alkoxy, a C 4 to C 10 cycloalkyl or substituted cycloalkenyl, --NHC 6 H 5 , --NR 10 R 11 wherein R 10 and R 11 can be the same or different and are each hydrogen, a C 1 to C 5 alkyl or substituted alkyl, phenyl or substituted phenyl; and Y is a C 1 to C 10 alkylene or substituted alkylene; and the pharmaceutically acceptable salts thereof, and mixtures thereof; provided that R 1 is not phenyl, chlorophenyl, methoxyphenyl or n-butyl when R 5 is hydrogen, R 6 is --CO--R 9 , and R 9 is ethoxy or when R 6 is hydrogen, R 5 is --CO--R 9 , and R 9 is ethoxy; and further provided that R 1 is not phenyl when R 5 is hydrogen, R 6 is --CO--R 9 , and R 9 is methoxy or when R 6 is hydrogen, R 5 is --CO--R 9 , and R 9 is methoxy.