US5034506A
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Uncharged morpholino-based polymers having achiral intersubunit linkages
Assignee: Sarepta Therapeutics Inc
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Filing: 1989-12-20
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Granted: 1991-07-23
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Expires: 2009-12-20
Abstract
Abstract A polymer composition is disclosed composed of morpholino subunit structures which are linked together by uncharged, achiral linkages. These linkages are one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
Inventors
- 👤 James E. Summerton
- 👤 Dwight D. Weller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 11:11
CPC Classifications
C; C07; C07H; C07H21/00; C08; C08G; C08G75/00; C08G75/18; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/545; A61K47/548; A61K47/56; A61K47/59; C07K; C07K14/00; C07K14/001; C07K14/003; C08G75/20; C08G75/24; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/682; C12Q1/6839; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00718; B01J2219/0072
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
69 words
A polymer composition comprised of morpholino subunit structures of the form: ##STR2## where (i) the structures are linked together by uncharged, achiral linkages, one to three atoms long, joining the morpholino nitrogen of one subunit to the 5' , exocyclic carbon of an adjacent subunit, and (ii) P i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Claim 2
Dependent Claim
69 words
A polymer composition comprised of morpholino subunit structures of the form: ##STR2## where (i) the structures are linked together by uncharged, achiral linkages, one to three atoms long, joining the morpholino nitrogen of one subunit to the 5' , exocyclic carbon of an adjacent subunit, and (ii) P i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Claim 3
Dependent Claim
28 words
The composition of claim 1, wherein P i is selected from the group consisting of: ##STR3## where X is H, CH 3 , F, Cl, Br, or I.
Claim 4
Dependent Claim
19 words
The composition of claim 1, wherein the linked structures have a form selected from the group consisting of: ##STR4##
Claim 5
Dependent Claim
51 words
The composition of claim 1, wherein the linkage is of the form: ##STR5## where P i X is NH, NCH 3 , O, S, or CH 2 ; and, P 1 is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Claim 6
Dependent Claim
44 words
The composition of claim 1, wherein the linkage is of the form: ##STR6## where P i Y is O or S; and, P i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Claim 7
Dependent Claim
36 words
The composition of claim 1, wherein the linkage is of the form: ##STR7## where P i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Claim 8
Dependent Claim
46 words
The composition of claim 1, wherein the linkage is of the form ##STR8## where P i R is H or CH 3 ; and, P i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Claim 9
Dependent Claim
28 words
The composition of claim 1, which further includes a moiety at one or both termini which is effective to enhance the solubility of the polymer in aqueous medium.
Claim 10
Dependent Claim
12 words
The composition of claim 7, wherein the terminal moiety is polyethylene glycol.
Claim 11
Dependent Claim
12 words
The composition of claim 1, composed of at least 3 morpholino subunits.
Claim 12
Dependent Claim
16 words
The composition of claim 1, wherein at least one of the P i is a 2,6-diaminopurine.
Claim 13
Dependent Claim
16 words
The composition of claim 1, wherein at least one of the P i is a 5-halouracil.
Claim 14
Dependent Claim
18 words
The composition of claim 1, wherein at least of 70% of the P i are 2-amine containing purines.
References Cited (Backward Citations)
JPS63303341A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-22 | 1995-01-21 | 1995-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-22 | 1999-01-21 | 1999-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-22 | 2003-01-21 | 2003-07-23 | $7700.00 | Window Closed / Lapsed |