Abstract The present invention provides a dual-action tablet composition comprising: (a) an outer tablet comprising a first dose of active ingredient dispersed in a pH independent hydrophilic polymer matrix; and (b) an inner tablet comprising a second dose of active ingredient in a rapidly disintegrating excipient base. This dual-action tablet is especially efficacious for those active ingredients which have half lives of less than two hours and which experience decreased absorption efficiency in the lower gastrointestinal tract. Among the preferred dual-action tablet compositions is one wherein the active ingredient in both the inner and outer tablets is guaifenesin. Upon administration, the outer tablet provides a controlled release of the active ingredient while the inner tablet gives a second dose of active ingredient after the outer tablet has partially dissolved.
A dual-action tablet composition comprising: (a) an outer tablet comprising a first dose of guaifenesin and phenylpropanolamine HCl dispersed in a pH independent hydrophilic polymer matrix; and (b) an inner tablet comprising a second dose of guaifenesin and phenylpropanolamine HCl in a rapidly disintegrating excipient base.
Claim 2
Dependent Claim
46 words
A dual-action tablet composition comprising: (a) an outer tablet comprising a first dose of guaifenesin and phenylpropanolamine HCl dispersed in a pH independent hydrophilic polymer matrix; and (b) an inner tablet comprising a second dose of guaifenesin and phenylpropanolamine HCl in a rapidly disintegrating excipient base.
Claim 3
Dependent Claim
32 words
A dual-action tablet according to claim 1 wherein the pH independent hydrophilic polymer matrix contains hydroxypropylmethylcellulose at a level of from about 20% to about 50% by weight of the outer tablet.
Claim 4
Dependent Claim
29 words
A dual-action tablet according to claim 2 wherein said inner tablet contains polyvinylpyrrolidone at a level of from about 1% to about 5% by weight of the inner tablet.