US5030451A
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Topical slenderizing formulation containing cafeine carboxylic acid derivatives neutralized by organic bases, preparation thereof, and their use in the treatment of cellulite
Assignee: Pierre Fabre SA
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Filing: 1989-11-29
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Granted: 1991-07-09
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Expires: 2009-11-29
Abstract
Abstract The present invention relates to topical compositions containing caffeine carboxylates with organic bases, which are useful as slenderizing agents and in the treatment of cellulitis, as well as their preparation. The heterogeneous topical compositions of the invention contain, as active principle, a caffeine carboxylic acid which has been salified with a cosmetologically-acceptable organic base, the active principle preferably being present in the form of microparticles or microgranules suspended in a hydroalcoholic gel.
Inventors
- 👤 Marie-Therese Trebosc
- 👤 Gilbert Mouzin
- 👤 Henri Cousse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:07
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/494; A61K8/4953; A61Q; A61Q19/00; A61Q19/06
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
91 words
Heterogeneous cosmetic composition which can be used as a slenderizing agent or in the treatment of cellulitis, which comprises, an active principle selected from the group consisting of 3-nicotinol caffeine carboxylate, triethanolamine caffeine carboxylate, -pyrrolidinoethanol caffeine carboxylate and creationol caffeine carboxylate, said active principle being present in the form of microgranules or microparticles, in an amount between about 0.5 and 20% by weight of the total composition, and which microgranules or microparticles are heterogeneously distributed and suspended in a gel comprising water and a non-toxic alcohol in which they are insoluble.
Claim 2
Dependent Claim
91 words
Heterogeneous cosmetic composition which can be used as a slenderizing agent or in the treatment of cellulitis, which comprises, an active principle selected from the group consisting of 3-nicotinol caffeine carboxylate, triethanolamine caffeine carboxylate, -pyrrolidinoethanol caffeine carboxylate and creationol caffeine carboxylate, said active principle being present in the form of microgranules or microparticles, in an amount between about 0.5 and 20% by weight of the total composition, and which microgranules or microparticles are heterogeneously distributed and suspended in a gel comprising water and a non-toxic alcohol in which they are insoluble.
Claim 3
Dependent Claim
14 words
A composition according to claim 1, wherein the caffeine carboxylate is 3-nicotinol caffeine carboxylate.
Claim 4
Dependent Claim
14 words
A composition according to claim 1, wherein the caffeine carboxylate is triethanolamine caffeine carboxylate.
Claim 5
Dependent Claim
12 words
A composition according to claim 1, wherein the caffeine carboxylate is β-dimethylaminoethanol.
Claim 6
Dependent Claim
12 words
A composition according to claim 1, wherein the caffeine carboxylate is β-pyrrolidinoethanol.
Claim 7
Dependent Claim
14 words
A composition according to claim 1, wherein the caffeine carboxylate is creatinol caffeine carboxylate.
Claim 8
Dependent Claim
18 words
Composition of claim 3 wherein the microgranules or microparticles have a diameter between about 0.4 and 1 millimeter.
Claim 9
Dependent Claim
26 words
Composition of claim 1 wherein the microgranules or microparticles are present in an amount between about 1 and 10 percent by weight of the total composition.
Claim 10
Dependent Claim
26 words
Composition of claim 1 wherein the individual particles comprising the microgranules or microparticles are of an average size between about 5 and 20 microns in diameter.
Claim 11
Dependent Claim
26 words
Composition of claim 1 wherein the individual particles comprising the microparticles or microgranules are of an average size between about 5 and 15 microns in diameter.
Claim 12
Dependent Claim
13 words
A composition according to claim 1 wherein the composition also contains vitamin E.
Claim 13
Independent Claim
136 words
A method of preparing microparticles or microgranules containing as active principle a topically-acceptable organic salt of caffeine carboxylic acid, comprising the following steps, steps a) and c) being optional: a) a solid inert binder support is micronized until scales of an average size less than 50 microns are obtained, b) particles impregnated with active principle or particles of the active principle itself are micronized until particles of an average size less than 50 microns are obtained, c) the scales when obtained in step a) are mixed with the particles obtained in step b) d) a wetting agent is added; the product from step b) or c) is agglomerated and the agglomerated product is dried to produce a powder which, after drying, is screened to form microgranules or microparticles of about 0.2 to 2 millimeters in diameter.
Claim 14
Independent Claim
136 words
A method of preparing microparticles or microgranules containing as active principle a topically-acceptable organic salt of caffeine carboxylic acid, comprising the following steps, steps a) and c) being optional: a) a solid inert binder support is micronized until scales of an average size less than 50 microns are obtained, b) particles impregnated with active principle or particles of the active principle itself are micronized until particles of an average size less than 50 microns are obtained, c) the scales when obtained in step a) are mixed with the particles obtained in step b) d) a wetting agent is added; the product from step b) or c) is agglomerated and the agglomerated product is dried to produce a powder which, after drying, is screened to form microgranules or microparticles of about 0.2 to 2 millimeters in diameter.
Claim 15
Dependent Claim
21 words
Method of claim 12 wherein the microgranules or microparticles are heterogeneously mixed into a hydroalcoholic gel in which they are insoluble.
Claim 16
Dependent Claim
29 words
Method of claim 13 wherein the microgranules or microparticles are mixed into the gel in an amount of about 0.5 to 20 percent by weight of the total composition.
Claim 17
Dependent Claim
29 words
Method of claim 13 wherein the microgranules or microparticles are mixed into the gel in an amount of about 1 to 10 percent by weight of the total composition.
Claim 18
Independent Claim
130 words
A method of preparing a hydroalcoholic gel comprising microgranules containing as active principle a salt of caffeine carboxylic acid with a cosmetologically-acceptable organic base, wherein preparation of the microgranules comprises the following steps: a) an inert binder support is micronized until lamellae of an average size of less than 50 μm are obtained; b) particles impregnated with the active principle are micronized until particles of an average size of less than 50 μm are obtained; c) the lamellae obtained in Step a) are mixed with the particles obtained in Step b); d) an alcohol is added as wetting agent, the product dried, and the powder obtained is screened to form microgranules of a diameter between about 0.2 and 2 mm; and e) the powder is incorporated into a hydroalcoholic gel.
Claim 19
Independent Claim
130 words
A method of preparing a hydroalcoholic gel comprising microgranules containing as active principle a salt of caffeine carboxylic acid with a cosmetologically-acceptable organic base, wherein preparation of the microgranules comprises the following steps: a) an inert binder support is micronized until lamellae of an average size of less than 50 μm are obtained; b) particles impregnated with the active principle are micronized until particles of an average size of less than 50 μm are obtained; c) the lamellae obtained in Step a) are mixed with the particles obtained in Step b); d) an alcohol is added as wetting agent, the product dried, and the powder obtained is screened to form microgranules of a diameter between about 0.2 and 2 mm; and e) the powder is incorporated into a hydroalcoholic gel.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1994-07-08 | 1995-01-07 | 1995-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-08 | 1999-01-07 | 1999-07-09 | $3760.00 | Window Closed / Lapsed |
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