US5030216A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Osmotically driven syringe
Assignee: Alza Corp
•
Filing: 1989-12-15
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Granted: 1991-07-09
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Expires: 2009-12-15
Abstract
Abstract An implantable osmotically driven syringe is disclosed which can be used to deliver a beneficial agent, such as a drug, at a predetermined rate over an extended period of time. A movable piston divides the syringe into a beneficial agent-containing compartment and a driving compartment. The piston is movable into a position wherein the driving compartment has a volume of essentially zero. The syringe is driven by an osmotic engine which has a shaped wall surrounding, and in contact with, an osmotic solute. The wall is comprised of a semipermeable and/or microporous material which is permeable to the external fluid (e.g., water) but is impermeable to the solute. The engine also has a passageway forming a fluid flow path between the osmotic solute and the driving compartment. A portion of the wall is exposed to a fluid-containing external environment. At least about 30% of the wall which contacts the solute also is exposed to the fluid in the external environment. In operation, water from the external environment is imbided through the semipermeable wall forming a solution of the solvent in the osmotic engine. As fresh incoming fluid from the external environment is imbided by the engine, the solution is pumped through the passageway into the driving compartment. The pumping action drives the piston which causes the beneficial agent to be delivered by the syringe.
Inventors
- 👤 Felix Theeuwes
- 👤 Patrick S. L. Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/0002; A61K9/0004; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M2005/14513
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
249 words
An osmotically driven dispensing device for delivering a beneficial agent to an environment of use, the device comprising: a) a syringe having a chamber with a movable piston therein, the piston dividing the chamber into a beneficial agent-containing compartment and a driving compartment, the piston being movable into a position wherein the piston occupies substantially all of the drive compartment; b) an osmotic engine attached to the syringe adjacent the driving compartment, the engine comprising a shaped wall surrounding, and in contact with, an osmotic solute, the wall having an external surface exposed to a fluid in an external environment, and a passageway providing a fluid flow path between the osmotic solute and the driving compartment, the wall being comprised of a material that is permeable to the external fluid and having a sufficient degree of impermeability to the solute to generate an osmotic pressure differential across the wall when exposed to the external fluid, at least 30% of the wall which is in contact with the osmotic solute also being exposed to the external environment; wherein in operation, the external fluid is imbibed through the wall into the osmotic engine to form a solution of the osmotic solute, the solution being pumped through the passageway into the driving compartment as fresh fluid is imbibed through the wall, thereby exerting pressure on the piston and forcing the piston to move within the syringe chamber and deliver the beneficial agent from the beneficial agent-containing compartment to the environment of use.
Claim 2
Dependent Claim
249 words
An osmotically driven dispensing device for delivering a beneficial agent to an environment of use, the device comprising: a) a syringe having a chamber with a movable piston therein, the piston dividing the chamber into a beneficial agent-containing compartment and a driving compartment, the piston being movable into a position wherein the piston occupies substantially all of the drive compartment; b) an osmotic engine attached to the syringe adjacent the driving compartment, the engine comprising a shaped wall surrounding, and in contact with, an osmotic solute, the wall having an external surface exposed to a fluid in an external environment, and a passageway providing a fluid flow path between the osmotic solute and the driving compartment, the wall being comprised of a material that is permeable to the external fluid and having a sufficient degree of impermeability to the solute to generate an osmotic pressure differential across the wall when exposed to the external fluid, at least 30% of the wall which is in contact with the osmotic solute also being exposed to the external environment; wherein in operation, the external fluid is imbibed through the wall into the osmotic engine to form a solution of the osmotic solute, the solution being pumped through the passageway into the driving compartment as fresh fluid is imbibed through the wall, thereby exerting pressure on the piston and forcing the piston to move within the syringe chamber and deliver the beneficial agent from the beneficial agent-containing compartment to the environment of use.
Claim 3
Dependent Claim
55 words
The device of claim 1, wherein the osmotic engine comprises a shaped wall surrounding a layer of an osmotically effective solute, the shaped wall also surrounding a layer of a rigid, non-dissolving material, the rigid material providing a rigid support for the shaped wall in order to fixedly attach the osmotic engine to the syringe.
Claim 4
Dependent Claim
32 words
The device of claim 2, wherein the passageway extends through both the wall and the rigid, non-dissolving layer to provide a fluid flow path between the osmotic solute and the driving compartment.
Claim 5
Dependent Claim
27 words
The device of claim 2, wherein the rigid, non-dissolving layer is comprised of a material selected from the group consisting of rigid plastics, metals, ceramics and glasses.
Claim 6
Dependent Claim
15 words
The device of claim 4, wherein the rigid, non-dissolving layer is comprised of micropolyethylene wax.
Claim 7
Dependent Claim
12 words
The device of claim 1, wherein the syringe is comprised of plastic.
Claim 8
Dependent Claim
10 words
The device of claim 6, wherein the plastic comprises polypropylene.
Claim 9
Dependent Claim
16 words
The device of claim 1, wherein the semipermeable wall material is comprised of a cellulose ester.
Claim 10
Dependent Claim
22 words
The device of claim 1, wherein the cellulose ester is selected from the group consisting of cellulose acetate and cellulose acetate butyrate.
Claim 11
Dependent Claim
11 words
The device of claim 1, wherein the external fluid comprises water.
Claim 12
Dependent Claim
26 words
The device of claim 1, wherein the osmotically effective solute is selected from the group consisting of sodium chloride, potassium chloride, glucose, lactose and hydrophilic polymers.
Claim 13
Dependent Claim
14 words
The device of claim 1, wherein the osmotic engine is adhered to the syringe.
Claim 14
Dependent Claim
18 words
The device of claim 12, wherein the osmotic engine is adhered to the syringe using an acrylic-based adhesive.
Claim 15
Dependent Claim
27 words
The device of claim 1, wherein at least 50% of the wall which is in contact with the osmotic solute is also exposed to the external environment.
Claim 16
Dependent Claim
26 words
The device of claim 1, wherein substantially all of the wall which is in contact with the osmotic solute is also exposed to the external environment.
Claim 17
Dependent Claim
15 words
The device of claim 1, wherein the beneficial agent-containing compartment contains a liquid beneficial agent.
Claim 18
Dependent Claim
24 words
The device of claim 1, wherein the beneficial agent-containing compartment has a maximum volume when the volume of the driving compartment is essentially zero.
Claim 19
Dependent Claim
15 words
The device of claim 1, wherein the environment of use is within an animal body.
References Cited (Backward Citations)
US3173876A
Cited
US3133132A
Cited
US3276586A
Cited
US3546142A
Cited
US3541006A
Cited
US3541005A
Cited
US3995631A
Cited
US3732865A
Cited
US3760984A
Cited
US3971376A
Cited
US3995632A
Cited
US3946734A
Cited
US3987790A
Cited
DE2721752A1
Cited
US4320758A
Cited
US4327725A
Cited
US4410328A
Cited
US4474575A
Cited
US4539004A
Cited
US4723958A
Cited
US4838862A
Cited
US4874388A
Cited
US4929233A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-08 | 1995-01-07 | 1995-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-08 | 1999-01-07 | 1999-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-08 | 2003-01-07 | 2003-07-09 | $7700.00 | Window Closed / Lapsed |