US5028707A
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4-hydroxyquinaldic acid derivatives
Assignee: The University of Texas System
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Filing: 1989-11-20
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Granted: 1991-07-02
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Expires: 2009-11-20
Abstract
Abstract A 7-chloro-4-hydroxy-2-quinoline carbonyl azide and its use as a photoaffinity probe for the N-methyl-D-aspartate (NMDA) receptor complex on neurons are claimed. A number of other compounds, including 4-hydroxy-2-quinoline carbonyl azides, isocyanates, and amides are also provided. Purification and characterization of the NMDA receptor is described.
Inventors
- 👤 Alfred C. Nichols
- 👤 K. Lemone Yielding
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:05
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/38; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/533; G01N33/566
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
6 words
A compound having the formula: ##STR4##
Claim 2
Dependent Claim
6 words
A compound having the formula: ##STR4##
Claim 3
Dependent Claim
27 words
A compound having the formula: ##STR5## wherein A is chloro or hydrogen; wherein B is methoxy or hydrogen; and wherein C is chloro, bromo, iodo, or fluoro.
Claim 4
Dependent Claim
27 words
A compound having the formula: ##STR5## wherein A is chloro or hydrogen; wherein B is methoxy or hydrogen; and wherein C is chloro, bromo, iodo, or fluoro.
Claim 5
Dependent Claim
32 words
A compound having the formula: ##STR6## wherein A is azide; wherein B is chloro or hydrogen; wherein C is methody or hydrogen; and wherein D is chloro, bromo, iodo, fluoro, or hydrogen.
Claim 6
Dependent Claim
32 words
A compound having the formula: ##STR6## wherein A is azide; wherein B is chloro or hydrogen; wherein C is methody or hydrogen; and wherein D is chloro, bromo, iodo, fluoro, or hydrogen.
Claim 7
Dependent Claim
32 words
A compound having the formula: ##STR7## wherein A is isocyanate; wherein B is chloro or hydrogen; wherein C i methoxy or hydrogen; and wherein D is chloro, bromo, iodo, fluoro, or hydrogen.
Claim 8
Dependent Claim
32 words
A compound having the formula: ##STR7## wherein A is isocyanate; wherein B is chloro or hydrogen; wherein C i methoxy or hydrogen; and wherein D is chloro, bromo, iodo, fluoro, or hydrogen.
Claim 9
Dependent Claim
19 words
A compound having the formula: ##STR8## wherein A is azide; and wherein B is chloro, bromo, iodo, or fluoro.
Claim 10
Dependent Claim
19 words
A compound having the formula: ##STR8## wherein A is azide; and wherein B is chloro, bromo, iodo, or fluoro.
Claim 11
Dependent Claim
19 words
A compound having the formula: ##STR9## wherein A is isocyanate; and wherein B is chloro, bromo, iodo, or fluoro.
Claim 12
Dependent Claim
19 words
A compound having the formula: ##STR9## wherein A is isocyanate; and wherein B is chloro, bromo, iodo, or fluoro.
Claim 13
Dependent Claim
21 words
A compound having the formula: ##STR10## wherein A is azide; wherein B is methoxy; and wherein C is chloro or hydrogen.
Claim 14
Dependent Claim
21 words
A compound having the formula: ##STR10## wherein A is azide; wherein B is methoxy; and wherein C is chloro or hydrogen.
Claim 15
Dependent Claim
21 words
A compound having the formula: ##STR11## wherein A is isocyanate; wherein B is methoxy; and wherein C is chloro or hydrogen.
Claim 16
Dependent Claim
21 words
A compound having the formula: ##STR11## wherein A is isocyanate; wherein B is methoxy; and wherein C is chloro or hydrogen.
Claim 17
Dependent Claim
17 words
A compound having the formula: ##STR12## wherein A is azide; and wherein B is methoxy or hydrogen.
Claim 18
Dependent Claim
17 words
A compound having the formula: ##STR12## wherein A is azide; and wherein B is methoxy or hydrogen.
Claim 19
Dependent Claim
17 words
A compound having the formula: ##STR13## wherein A is isocyanate; and wherein B is methoxy or hydrogen.
Claim 20
Dependent Claim
17 words
A compound having the formula: ##STR13## wherein A is isocyanate; and wherein B is methoxy or hydrogen.
Claim 21
Dependent Claim
18 words
A compound having the formula: ##STR14## wherein A is azide; and wherein B is a halogen or hydrogen.
Claim 22
Dependent Claim
18 words
A compound having the formula: ##STR14## wherein A is azide; and wherein B is a halogen or hydrogen.
Claim 23
Dependent Claim
17 words
A compound having the formula: ##STR15## wherein A is isocyanate; and wherein B is halogen or hydrogen.
Claim 24
Dependent Claim
17 words
A compound having the formula: ##STR15## wherein A is isocyanate; and wherein B is halogen or hydrogen.
Claim 25
Dependent Claim
33 words
A compound having the formula: ##STR16## wherein A is azido carbonyl; wherein B is chloro or hydrogen; wherein C is methoxy or hydrogen; and wherein D is chloro, bromo, iodo, fluoro, or hydrogen.
Claim 26
Dependent Claim
33 words
A compound having the formula: ##STR16## wherein A is azido carbonyl; wherein B is chloro or hydrogen; wherein C is methoxy or hydrogen; and wherein D is chloro, bromo, iodo, fluoro, or hydrogen.
Claim 27
Dependent Claim
20 words
A compound having the formula: ##STR17## wherein A is azido carbonyl; and wherein B is chloro, bromo, iodo, or fluoro.
Claim 28
Dependent Claim
20 words
A compound having the formula: ##STR17## wherein A is azido carbonyl; and wherein B is chloro, bromo, iodo, or fluoro.
Claim 29
Dependent Claim
22 words
A compound having the formula: ##STR18## wherein A is azido carbonyl; wherein B is methoxy; and wherein C is chloro or hydrogen.
Claim 30
Dependent Claim
22 words
A compound having the formula: ##STR18## wherein A is azido carbonyl; wherein B is methoxy; and wherein C is chloro or hydrogen.
Claim 31
Dependent Claim
18 words
A compound having the formula ##STR19## wherein A is azido carbonyl; and wherein B is methoxy or hydrogen.
Claim 32
Dependent Claim
18 words
A compound having the formula ##STR19## wherein A is azido carbonyl; and wherein B is methoxy or hydrogen.
Claim 33
Dependent Claim
19 words
A compound having the formula: ##STR20## wherein A is azido carbonyl; and wherein B is a halogen or hydrogen.
Claim 34
Dependent Claim
19 words
A compound having the formula: ##STR20## wherein A is azido carbonyl; and wherein B is a halogen or hydrogen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-01 | 1994-12-31 | 1995-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-01 | 1998-12-31 | 1999-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-01 | 2002-12-31 | 2003-07-02 | $7700.00 | Window Closed / Lapsed |