US5026544A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods and compositions for inhibiting the growth of neoplastic cells
Assignee: The University of Texas System
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Filing: 1988-02-16
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Granted: 1991-06-25
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Expires: 2008-02-16
Abstract
Abstract The present disclosure is directed to the use of combinations of a papaverine family member agent together with an interferon for the treatment of proliferative disorders such as neoplasias and hyperplasias. Disclosed are compositions and formulations which take advantage of the synergistic antiproliferative activities of these agents and the use of these compositions and formulations in the treatment of these disorders.
Inventors
- 👤 Thomas B. Albrecht
- 👤 Thomas E. Albrecht
- 👤 William R. Fleischmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:39
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
27 words
A method for inhibiting the growth of neoplastic cells comprising subjecting the cells to an effective concentration of a papaverine family agent in combination with an interferon.
Claim 2
Independent Claim
27 words
A method for inhibiting the growth of neoplastic cells comprising subjecting the cells to an effective concentration of a papaverine family agent in combination with an interferon.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the papaverine family agent comprises papaverine, ethaverine or dioxyline.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the interferon comprises interferon gamma.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the interferon comprises interferon alpha.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein the interferon comprises interferon beta.
Claim 7
Dependent Claim
18 words
The method of claim 1 wherein the papaverine family agent comprises papaverine and the interferon comprises interferon gamma.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the neoplastic cells comprise sarcomas, carcinomas or leukemic cells.
Claim 9
Dependent Claim
13 words
A pharmaceutical composition comprising a papaverine family agent in combination with an interferon.
Claim 10
Dependent Claim
13 words
A pharmaceutical composition comprising a papaverine family agent in combination with an interferon.
Claim 11
Dependent Claim
15 words
The composition of claim 8 wherein the papaverine family agent comprises papaverine, ethaverine or dioxyline.
Claim 12
Dependent Claim
11 words
The composition of claim 8 wherein the interferon comprises interferon gamma.
Claim 13
Dependent Claim
11 words
The composition of claim 8 wherein the interferon comprises interferon alpha.
Claim 14
Dependent Claim
11 words
The composition of claim 8 wherein the interferon comprises interferon beta.
Claim 15
Dependent Claim
18 words
The composition of claim 8 wherein the papaverine family agent comprises papaverine and the interferon comprises interferon gamma.
Claim 16
Dependent Claim
22 words
The pharmaceutical composition of claim 8 wherein the papaverine family agent and interferon are admixed in a preparation suitable for topical administration.
References Cited (Backward Citations)
US4018927A
Cited
US4800081A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-24 | 1994-12-24 | 1995-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-24 | 1998-12-24 | 1999-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-24 | 2002-12-24 | 2003-06-25 | $7700.00 | Window Closed / Lapsed |