US5024756A
Expired / Lapsed
US
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Dialysis system and method therefor
Assignee: Gambro Lundia AB
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Filing: 1989-02-28
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Granted: 1991-06-18
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Expires: 2009-02-28
Abstract
Abstract A dialysis system and method is based upon a comparison of the value of a parameter being measured of the dialysis liquid after the dialyzer with a set value of the corresponding parameter being controlled before the dialyzer. Based upon this comparison, a measure of the dialysis performed is obtained, and with the assistance of this measured value, as well as the knowledge of other factors, for example, adjusted values relevant for the analysis, conditions of the patient's blood can be determined theoretically and thereby controlled.
Inventors
- 👤 Jan P. Sternby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 19:29
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1601; A61M1/1603; A61M1/1605; A61M1/1607; A61M1/1609; A61M1/1617; A61M1/1621; A61M1/1647; A61M1/165; A61M1/1654; A61M1/1656; A61M1/166; A61M1/1664; A61M2205/00; A61M2205/33; A61M2205/3317; A61M2205/3324; A61M2205/3331; A61M2205/3334; A61M2205/3368; A61M2205/50
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
124 words
A dialysis system comprising a dialyzer having (i) a dialysis liquid input side and a dialysis liquid output side for the flow of a dialysis liquid therethrough, and (ii) a blood input side and a blood output side for the flow of blood therethrough, control means for controlling one or more parameters of the dialysis liquid at a non-measured desired set value on the dialysis liquid input side of said dialyzer, measuring means for measuring the value of at least one of said parameters of said dialysis liquid on the dialysis liquid output side of said dialyzer, and comparison means for comparing the value of the measured parameter with the non-measured desired set value of the corresponding parameter being controlled by said control means.
Claim 2
Dependent Claim
124 words
A dialysis system comprising a dialyzer having (i) a dialysis liquid input side and a dialysis liquid output side for the flow of a dialysis liquid therethrough, and (ii) a blood input side and a blood output side for the flow of blood therethrough, control means for controlling one or more parameters of the dialysis liquid at a non-measured desired set value on the dialysis liquid input side of said dialyzer, measuring means for measuring the value of at least one of said parameters of said dialysis liquid on the dialysis liquid output side of said dialyzer, and comparison means for comparing the value of the measured parameter with the non-measured desired set value of the corresponding parameter being controlled by said control means.
Claim 3
Dependent Claim
48 words
The dialysis system in accordance with claim 1, further including means for adapting the value of the measured parameter for the calculation and/or control of a corresponding blood parameter, said blood parameter being altered as a function of the value of the measured parameter of the dialysis liquid.
Claim 4
Dependent Claim
37 words
The dialysis system in accordance with claim 1, wherein said measuring means comprises a conductivity meter for the measurement of the conductivity of the dialysis liquid for the calculation and/or control of the conductivity in the blood.
Claim 5
Dependent Claim
21 words
The dialysis system in accordance with claim 3, wherein said conductivity of the blood corresponds to the sodium ion content thereof.
Claim 6
Dependent Claim
68 words
The dialysis system in accordance with claim 3, wherein the conductivity of the blood is calculated according to the formula: Cd.sub.out =Cd.sub.in +(Cb.sub.in -Cd.sub.in)×K wherein: Cd out =the measured conductivity or concentration of ions in the dialysis liquid, Cd in =the desired conductivity or concentration of ions in the fresh dialysis liquid, Cb in =the conductivity or concentration of ions in the untreated blood, and K=a proportionality constant.
Claim 7
Dependent Claim
25 words
The dialysis system in accordance with claim 5, wherein said ions are selected from the group consisting of sodium ions, potassium ions, and calcium ions.
Claim 8
Dependent Claim
84 words
The dialysis system in accordance with claim 5, wherein the factor K is determined by incrementing the desired value of the conductivity of the dialysis liquid, a constant amount, from an initial value in the order of magnitude of from about 13.7 to 14.0 mS/cm, wherein after each increment of the desired value the factor K is determined from a comparison between the desired conductivity on the dialysis liquid input side and the conductivity measured on the dialysis liquid output side of the dialyzer.
Claim 9
Dependent Claim
33 words
The dialysis system in accordance with claim 5, wherein the factor K is determined empirically as a function of at least the blood flow rate and the liquid flow rate through said dialyzer.
Claim 10
Dependent Claim
36 words
The dialysis system in accordance with claim 5, wherein the factor K corresponds to the formula D1/Qd; wherein: D1=the dialysance value for the conductivity of the dialysis liquid, and Qd=the flow rate of the dialysis liquid.
Claim 11
Dependent Claim
43 words
The dialysis system in accordance with claim 1, wherein said measuring means comprises an ion-selective electrode for the measurement of the content of a preselected ion in the dialysis liquid for the calculation and/or control of the corresponding ion content in the blood.
Claim 12
Dependent Claim
40 words
The dialysis system in accordance with claim 1, wherein said measuring means comprises a gas analyzer for the measurement of the gas content in the dialysis liquid for the calculation and/or control of the corresponding gas content in the blood.
Claim 13
Dependent Claim
61 words
The dialysis system in accordance with claim 1, further including composition controlling means for controlling the composition of the dialysis liquid on the dialysis liquid input side of said dialyzer as a function of the parameter being measured by said measuring means, whereby the operation of said control means is a direct function of the control of a corresponding blood parameter.
Claim 14
Dependent Claim
44 words
The dialysis system in accordance with claim 12, wherein said composition controlling means is operative for the adjustment of the composition of the dialysis liquid before the dialyzer to bring about an equilibrium between the conductivity in the dialysis liquid and in the blood.
Claim 15
Dependent Claim
33 words
The dialysis system in accordance with claim 13, wherein the blood conductivity corresponds to the ion concentration in the blood selected from the group consisting of sodium ions, potassium ions and calcium ions.
Claim 16
Dependent Claim
66 words
The dialysis system in accordance with claim 1, further including means for measuring the value of at least one of said parameters of the dialysis liquid on the dialysis liquid input side of said dialyzer, and by pass means for bypassing fresh dialysis liquid passed said dialyzer and directly to said measuring means on the dialysis liquid output side of said dialyzer for the calibration thereof.
Claim 17
Dependent Claim
63 words
The dialysis system in accordance with claim 1, further including means for measuring the value of at least one of said parameters of said dialysis liquid on the dialysis liquid input side of said dialyzer, said comparison means for comparing the values of the measured parameter before and after said dialyzer for the calculation and/or control of the corresponding parameter in the blood.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-06-17 | 1994-12-17 | 1995-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-17 | 1998-12-17 | 1999-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-17 | 2002-12-17 | 2003-06-18 | $7700.00 | Window Closed / Lapsed |