US5019369A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of targeting tumors in humans
Assignee: Nexstar Pharmaceuticals Inc
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Filing: 1988-12-01
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Granted: 1991-05-28
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Expires: 2008-12-01
Abstract
Abstract A method is provided for delivering micellular particles containing a radiolabelled marker to tumors within humans. The micellular particles are less than approximately 2000 ANGSTROM and incorporate essentially chemically pure phospholipid molecules in their external surface. Human patients given intravenous injections of such radiolabelled micellular particles showed tumors imaged by such method, without developing symptoms related to the micellular particles.
Inventors
- 👤 Cary A. Presant
- 👤 Richard T. Proffitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:18
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K51/00; A61K51/12; A61K51/1217; A61K51/1234; A61K2121/00; A61K2123/00; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
85 words
A method of targeting tumors in the breast, lung, prostate, kidney, colon, lymph, bone, lymph node, soft tissue including mediastinum, liver and spinal cord in humans comprising providing small umilamellar vesicles of less than about 2000Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive or chemotherapeutic agent into said vesicles and introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor for treating and/or imaging said tumor.
Claim 2
Independent Claim
85 words
A method of targeting tumors in the breast, lung, prostate, kidney, colon, lymph, bone, lymph node, soft tissue including mediastinum, liver and spinal cord in humans comprising providing small umilamellar vesicles of less than about 2000Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive or chemotherapeutic agent into said vesicles and introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor for treating and/or imaging said tumor.
Claim 3
Independent Claim
73 words
A method of targeting and imaging tumors in the breast, lung, prostate, kidney, colon or lymph of humans, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 4
Independent Claim
73 words
A method of targeting and imaging tumors in the breast, lung, prostate, kidney, colon or lymph of humans, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 5
Dependent Claim
12 words
A method according to claim 2 wherein the agent emits gamma radiation.
Claim 6
Dependent Claim
11 words
A method according to claim 3 wherein the agent comprises Indium-111.
Claim 7
Dependent Claim
18 words
A method according to claim 2 wherein the radioactive agent is Gallium 67, Technetium 99m or Iodine 131.
Claim 8
Dependent Claim
13 words
A method according to claim 2 wherein said phospholipid molecules comprise distearoyl phosphatidylcholine.
Claim 9
Dependent Claim
20 words
The method set forth in claim 6 wherein said vesicles further comprise cholesterol to enhance the stability of said vesicles.
Claim 10
Dependent Claim
13 words
The method of claim 2 wherein charged molecules are attached to said vesicles.
Claim 11
Dependent Claim
23 words
The method of claim 8 wherein said chemically pure phospholipid molecules are neutral and wherein the charged molecules are positively or negatively charged.
Claim 12
Independent Claim
80 words
A method of targeting and imaging bone, lymph node, soft tissue including mediastinum, lung, liver and spinal cord in humans for the presence of tumors, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 13
Independent Claim
80 words
A method of targeting and imaging bone, lymph node, soft tissue including mediastinum, lung, liver and spinal cord in humans for the presence of tumors, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 14
Independent Claim
65 words
A method of targeting and imaging metastatic tumors in humans, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 15
Independent Claim
65 words
A method of targeting and imaging metastatic tumors in humans, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 16
Independent Claim
84 words
A method of targeting and imaging metastatic tumors arising from a primary breast cancer, oat cell carcinoma, prostatic carcinoma, renal cell carcinoma, colon carcinoma or malignant lymphoma in humans, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 17
Independent Claim
84 words
A method of targeting and imaging metastatic tumors arising from a primary breast cancer, oat cell carcinoma, prostatic carcinoma, renal cell carcinoma, colon carcinoma or malignant lymphoma in humans, comprising providing small unilamellar vesicles of less than about 2,000 Å comprising chemically pure phospholipid molecules that are stable to leakage in vitro and in vivo, incorporating a radioactive agent into said vesicles, introducing such vesicles into the bloodstream of a human to obtain movement of the vesicles to the tumor, and imaging said tumor.
Claim 18
Independent Claim
20 words
The method of claims 2, 10, 11 or 12 in which said micellar vesicles are less than approximately 1000 Å.
Claim 19
Dependent Claim
16 words
The method of claim 13 in which said vesicles are from about 500 to about 700Å.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-27 | 1994-11-26 | 1995-05-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-27 | 1998-11-26 | 1999-05-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-27 | 2002-11-26 | 2003-05-28 | $7700.00 | Window Closed / Lapsed |