US5013761A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Serotonin antagonists
Assignee: Eli Lilly and Co
•
Filing: 1989-11-08
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Granted: 1991-05-07
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Expires: 2009-11-08
Abstract
Abstract This invention provides a method of selectively antagonizing the 5-HT 1A receptor in mammals by administering aryloxypropanolamines. Novel aryloxypropanolamines are also claimed.
Inventors
- 👤 Edward E. Beedle
- 👤 David W. Robertson
- 👤 David T. Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:07
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/08; C07C; C07C217/00; C07C217/02; C07C217/04; C07C217/28; C07C217/30; C07C2601/00; C07C2601/06; C07C2601/08; C07C2601/12; C07C2601/14; C07C2601/18; C07C2602/00; C07C2602/02; C07C2602/14; C07C2602/20
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
84 words
A compound of Formula ##STR13## where m is 0-3, and Z c is (C 7 -C 8 cycloalkyl)--G--, C 6 -C 10 alkyl, phenyl substituted C 2 -C 10 alkyl, --(C 1 -C 4 alkylidene)--T--(C 1 -C 4 alkyl), or ##STR14## where each G is independently a bond or C 1 -C 4 alkylidene, a and c are independently 1-5, b is 0-5, and (a+c) is greater than 2, and T is --O--, --S--, --SO--, or --SO 2 --, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
84 words
A compound of Formula ##STR13## where m is 0-3, and Z c is (C 7 -C 8 cycloalkyl)--G--, C 6 -C 10 alkyl, phenyl substituted C 2 -C 10 alkyl, --(C 1 -C 4 alkylidene)--T--(C 1 -C 4 alkyl), or ##STR14## where each G is independently a bond or C 1 -C 4 alkylidene, a and c are independently 1-5, b is 0-5, and (a+c) is greater than 2, and T is --O--, --S--, --SO--, or --SO 2 --, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
The compound of claim 17 which is 1-(2-cyclopentylphenoxy)-3-(cycloheptylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
14 words
The compound of claim 17 which is 1-(2-cyclopentylphenoxy)-3-(cyclooctylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
The compound of claim 17 which is 1-(2-cyclopentylphenoxy)-3-(1,2,2-dimethylpropylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
14 words
The compound of claim 17 which is 1-(2-cyclopentylphenoxy)-3-(1,1-dimethylbutylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
14 words
The compound of claim 17 which is 1-(2-cyclopentylphenoxy)-3-(myrtanylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
29 words
A method of selectively antagonizing the 5-HT 1 receptor in a mammal comprising administering to a mammal an effective 5-HT 1 antagonizing amount of a compound of claim 1.
Claim 9
Dependent Claim
21 words
The method according to claim 7 employing a compound wherein Z c is cycloheptyl, cyclooctyl, or C 6 -C 8 alkyl.
Claim 10
Dependent Claim
14 words
The method according to claim 8 employing 1-(2-cyclopentylphenoxy)-3-(cycloheptylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
14 words
The method according to claim 8 employing 1-(2-cyclopentylphenoxy)-3-(cyclooctylamino)-2-propanol or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1994-05-06 | 1994-11-05 | 1995-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-06 | 1998-11-05 | 1999-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-06 | 2002-11-05 | 2003-05-07 | $7700.00 | Window Closed / Lapsed |