US5011843A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of glaucoma using phosphodiesterase inhibitors
Assignee: Ciba Vision Corp
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Filing: 1990-06-01
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Granted: 1991-04-30
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Expires: 2010-06-01
Abstract
Abstract Lowering of intraocular pressure, e.g. in the treatment of glaucoma is carried out by administering a phosphodiesterase inhibitor to a patient. Particular ophthalmic pharmaceutical compositions are disclosed for topical application to the eye.
Inventors
- 👤 John W. Shell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/535; A61K31/495; A61K31/505
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
114 words
A method of lowering intraocular pressure in a mammal which comprises administering to the eye of said mammal a pharmaceutical composition comprising a therapeutically effective amount of a phosphodiesterase inhibitor of the following formula: ##STR5## wherein R 7 is hydrogen provided that R 7 is hydrogen only when the dotted line linkage represents a saturated bond; R 8 is hydrogen, lower alkyl, cycloalkyl having 4-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl group has 4-8 carbon atoms and the alkyl group has 1-3 carbon atoms, haloalkyl having 1-3 halogen atoms and 1-4 carbon atoms, norbornyl and norbornylmethyl; R 9 is lower alkyl, and the dotted line linkage represents a saturated bond or a double bond.
Claim 2
Independent Claim
114 words
A method of lowering intraocular pressure in a mammal which comprises administering to the eye of said mammal a pharmaceutical composition comprising a therapeutically effective amount of a phosphodiesterase inhibitor of the following formula: ##STR5## wherein R 7 is hydrogen provided that R 7 is hydrogen only when the dotted line linkage represents a saturated bond; R 8 is hydrogen, lower alkyl, cycloalkyl having 4-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl group has 4-8 carbon atoms and the alkyl group has 1-3 carbon atoms, haloalkyl having 1-3 halogen atoms and 1-4 carbon atoms, norbornyl and norbornylmethyl; R 9 is lower alkyl, and the dotted line linkage represents a saturated bond or a double bond.
Claim 3
Dependent Claim
16 words
The method of claim 1, wherein said quinazolinone is represented by the following formula (IIa): ##STR6##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-29 | 1994-10-29 | 1995-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-29 | 1998-10-29 | 1999-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-29 | 2002-10-29 | 2003-04-30 | $7700.00 | Window Closed / Lapsed |